DegronMD

Uniprot ID: Q9Y5H7

Source protein: Protocadherin alpha-5

Source gene: PCDHA5

Class: LIG_APCC_ABBA_1

Location: 507:512

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7853

ASA_SCORE: 40.45

COIL: 0.356

CONS_SCORE: 0.6349

DSS_SCORE: 0.2332

HELIX: 0.0098

FCONS_SCORE: 1.3495

RIG_SCORE: 0.75

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q520K	TCGA-49-AAR4	LUAD	TCGA	VSVHAE	LIG_APCC_ABBA_1	0.1111
p.Q520K	DO218920	LUAD	ICGC	VSVHAE	LIG_APCC_ABBA_1	0.1111
p.P502R	TCGA-49-AARQ	LUAD	TCGA	VSVHAE	LIG_APCC_ABBA_1	0.1944
p.P502R	DO51189	LUAD	ICGC	VSVHAE	LIG_APCC_ABBA_1	0.1944
p.S513R	TCGA-55-8511	LUAD	TCGA	VSVHAE	LIG_APCC_ABBA_1	0.75
p.S513R	DO24940	LUAD	ICGC	VSVHAE	LIG_APCC_ABBA_1	0.75
p.V498L	TCGA-86-8358	LUAD	TCGA	VSVHAE	LIG_APCC_ABBA_1	0.0833
p.V498L	DO25471	LUAD	ICGC	VSVHAE	LIG_APCC_ABBA_1	0.0833
p.A511S	TCGA-91-7771	LUAD	TCGA	VSVHAE	LIG_APCC_ABBA_1	0.6477
p.A511S	DO25807	LUAD	ICGC	VSVHAE	LIG_APCC_ABBA_1	0.6477
p.S508L	TCGA-A2-A0D4	BRCA	TCGA	VSVHAE	LIG_APCC_ABBA_1	0.6556
p.S508L	TCGA-EE-A182	SKCM	TCGA	VSVHAE	LIG_APCC_ABBA_1	0.6556
p.S508L	TCGA-W3-AA1R	SKCM	TCGA	VSVHAE	LIG_APCC_ABBA_1	0.6556
p.S508L	DO5347	BRCA	ICGC	VSVHAE	LIG_APCC_ABBA_1	0.6556
p.S508L	DO37814	SKCM	ICGC	VSVHAE	LIG_APCC_ABBA_1	0.6556
p.S508L	DO51275	SKCM	ICGC	VSVHAE	LIG_APCC_ABBA_1	0.6556
p.R497Q	TCGA-A5-A0G2	UCEC	TCGA	VSVHAE	LIG_APCC_ABBA_1	0.0556
p.R497Q	TCGA-A6-6648	COAD	TCGA	VSVHAE	LIG_APCC_ABBA_1	0.0556
p.R497Q	DO10196	COAD	ICGC	VSVHAE	LIG_APCC_ABBA_1	0.0556
p.R497Q	DO41235	UCEC	ICGC	VSVHAE	LIG_APCC_ABBA_1	0.0556
p.R497Q	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	VSVHAE	LIG_APCC_ABBA_1	0.0556
p.R497Q	ACH-002313	Lymphoma	CCLE	VSVHAE	LIG_APCC_ABBA_1	0.0556
p.R497Q	TK	haematopoietic_and_lymphoid_tissue	COSMIC	VSVHAE	LIG_APCC_ABBA_1	0.0556
p.G514S	TCGA-A6-3809	COAD	TCGA	VSVHAE	LIG_APCC_ABBA_1	0.2778
p.G514S	DO8722	COAD	ICGC	VSVHAE	LIG_APCC_ABBA_1	0.2778
p.Y517H	TCGA-AP-A054	UCEC	TCGA	VSVHAE	LIG_APCC_ABBA_1	0.1944
p.Y517H	DO42256	UCEC	ICGC	VSVHAE	LIG_APCC_ABBA_1	0.1944
p.R501H	TCGA-AP-A1DK	UCEC	TCGA	VSVHAE	LIG_APCC_ABBA_1	0.1667
p.R501H	DO42033	UCEC	ICGC	VSVHAE	LIG_APCC_ABBA_1	0.1667
p.E500G	DO48385	BLCA	ICGC	VSVHAE	LIG_APCC_ABBA_1	0.1389
p.S504L	DO48369	BLCA	ICGC	VSVHAE	LIG_APCC_ABBA_1	0.25
p.A518V	DO45079	LINC	ICGC	VSVHAE	LIG_APCC_ABBA_1	0.1667
p.R501P	DO231018	LUSC	ICGC	VSVHAE	LIG_APCC_ABBA_1	0.1667
p.E500K	DO229268	THCA	ICGC	VSVHAE	LIG_APCC_ABBA_1	0.1389
p.E500K	SIDM00545	Melanoma	GDSC	VSVHAE	LIG_APCC_ABBA_1	0.1389
p.E500K	ACH-000987	Skin Cancer	CCLE	VSVHAE	LIG_APCC_ABBA_1	0.1389
p.E500K	Mewo	skin	COSMIC	VSVHAE	LIG_APCC_ABBA_1	0.1389
p.Q520H	SIDM00810	Non-Small Cell Lung Carcinoma	GDSC	VSVHAE	LIG_APCC_ABBA_1	0.1111
p.Q520H	A427	lung	COSMIC	VSVHAE	LIG_APCC_ABBA_1	0.1111
p.A511T	SIDM00364	B-Lymphoblastic Leukemia	GDSC	VSVHAE	LIG_APCC_ABBA_1	0.6028
p.A511T	ACH-002059	Leukemia	CCLE	VSVHAE	LIG_APCC_ABBA_1	0.6028
p.A511T	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	VSVHAE	LIG_APCC_ABBA_1	0.6028
p.K515N	SIDM00333	Endometrial Carcinoma	GDSC	VSVHAE	LIG_APCC_ABBA_1	0.3611
p.K515N	ACH-000988	Endometrial/Uterine Cancer	CCLE	VSVHAE	LIG_APCC_ABBA_1	0.3611
p.K515N	MFE-319	endometrium	COSMIC	VSVHAE	LIG_APCC_ABBA_1	0.3611

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSVHAE

Degron related mutations and impact score

Drug responses associated with PCDHA5 mutations

All proteins holding degron of VSVHAE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5H7	Protocadherin alpha-5	LIG_APCC_ABBA_1	507:512	VSVHAE	APC,CDC20,FZR1	0.7853	More...