DegronMD - Q9Y5R5(DMRT2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P295A	TCGA-13-1509	OV	TCGA	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.2222
p.P295A	DO30740	OV	ICGC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.2222
p.P276H	TCGA-33-4566	LUSC	TCGA	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.1944
p.P276H	DO26790	LUSC	ICGC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.1944
p.P291T	TCGA-67-3771	LUAD	TCGA	NSYKSAYSPSP	CBL_PTK	281:291	Mutation altering degron motif	0.7031
p.P291T	DO25797	LUAD	ICGC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation altering degron motif	0.7031
p.N301I	TCGA-A5-A0GB	UCEC	TCGA	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.0556
p.N301I	DO41434	UCEC	ICGC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.0556
p.S296I	TCGA-AG-A002	READ	TCGA	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.1944
p.S296I	TCGA-FI-A2D5	UCEC	TCGA	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.1944
p.S296I	DO41331	UCEC	ICGC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.1944
p.K297N	TCGA-AX-A05Z	UCEC	TCGA	NSYKSAYSPSP	CBL_PTK	281:291	Mutation substituting flanking lysine	0.2778
p.K297N	DO40884	UCEC	ICGC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation substituting flanking lysine	0.2778
p.R273C	TCGA-BG-A220	UCEC	TCGA	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.1111
p.R273C	DO41784	UCEC	ICGC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.1111
p.R273C	SIDM00813	Non-Cancerous	GDSC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.1111
p.R273C	ACH-001182	Unknown	CCLE	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.1111
p.R273C	RPMI-6666	haematopoietic and lymphoid tissue	COSMIC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.1111
p.P271R	TCGA-FJ-A3ZF	BLCA	TCGA	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.0556
p.P271R	DO500	BLCA	ICGC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.0556
p.S290N	DO222404	BTCA	ICGC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation altering degron motif	0.5958
p.S282F	DO222653	MELA	ICGC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation altering degron motif	0.6871
p.S282F	DO229491	SKCA	ICGC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation altering degron motif	0.6871
p.S285R	DO222843	MELA	ICGC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation altering degron motif	0.6316
p.D298N	DO229446	SKCA	ICGC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.1389
p.P271A	SIDM01265	Plasma Cell Myeloma	GDSC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.0556
p.P271A	SIDM00672	Hepatocellular Carcinoma	GDSC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.0556
p.P271A	SIDM00330	Neuroblastoma	GDSC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.0556
p.P271A	SIDM00082	Melanoma	GDSC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.0556
p.P271A	SIDM00633	Breast Carcinoma	GDSC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.0556
p.P271A	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.0556
p.P271A	SIDM00254	Neuroblastoma	GDSC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.0556
p.P271A	SIDM00844	Burkitt's Lymphoma	GDSC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.0556
p.P271A	SIDM00793	Burkitt's Lymphoma	GDSC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.0556
p.P271A	SIDM00863	Burkitt's Lymphoma	GDSC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.0556
p.P271A	SIDM00257	Neuroblastoma	GDSC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.0556
p.P271A	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.0556
p.P294R	SIDM00879	Breast Carcinoma	GDSC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.25
p.P294R	ACH-000349	Breast Cancer	CCLE	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.25
p.P294R	HCC1500	breast	COSMIC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.25
p.Y287C	ACH-001389	Breast Cancer	CCLE	NSYKSAYSPSP	CBL_PTK	281:291	Mutation altering degron motif	0.7087
p.V284A	GMS-10	central nervous system	COSMIC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation altering degron motif	0.6936
p.R278Q	MES-SA	soft tissue	COSMIC	NSYKSAYSPSP	CBL_PTK	281:291	Mutation rewiring degron network	0.25

Kaplan plot for DMRT2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DMRT2

UniProt ID: Q9Y5R5

Entrez ID: 10655

Protein name: Doublesex- and mab-3-related transcription factor 2 (Doublesex-like 2 protein) (DSXL-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DMRT2 in