DegronMD

Uniprot ID: Q9Y5R5

Source protein: Doublesex- and mab-3-related transcription factor 2

Source gene: DMRT2

Class: CBL_PTK

Location: 281:291

E3 ligase: CBL

DEGRON score: 0.951

ASA_SCORE: 76.5091

COIL: 0.881

CONS_SCORE: 0.4669

DSS_SCORE: 0.4484

HELIX: 0.0815

FCONS_SCORE: 1.0076

RIG_SCORE: 0.6487

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P295A	TCGA-13-1509	OV	TCGA	NSYKSAYSPSP	CBL_PTK	0.2222
p.P295A	DO30740	OV	ICGC	NSYKSAYSPSP	CBL_PTK	0.2222
p.P276H	TCGA-33-4566	LUSC	TCGA	NSYKSAYSPSP	CBL_PTK	0.1944
p.P276H	DO26790	LUSC	ICGC	NSYKSAYSPSP	CBL_PTK	0.1944
p.P291T	TCGA-67-3771	LUAD	TCGA	NSYKSAYSPSP	CBL_PTK	0.7031
p.P291T	DO25797	LUAD	ICGC	NSYKSAYSPSP	CBL_PTK	0.7031
p.N301I	TCGA-A5-A0GB	UCEC	TCGA	NSYKSAYSPSP	CBL_PTK	0.0556
p.N301I	DO41434	UCEC	ICGC	NSYKSAYSPSP	CBL_PTK	0.0556
p.S296I	TCGA-AG-A002	READ	TCGA	NSYKSAYSPSP	CBL_PTK	0.1944
p.S296I	TCGA-FI-A2D5	UCEC	TCGA	NSYKSAYSPSP	CBL_PTK	0.1944
p.S296I	DO41331	UCEC	ICGC	NSYKSAYSPSP	CBL_PTK	0.1944
p.K297N	TCGA-AX-A05Z	UCEC	TCGA	NSYKSAYSPSP	CBL_PTK	0.2778
p.K297N	DO40884	UCEC	ICGC	NSYKSAYSPSP	CBL_PTK	0.2778
p.R273C	TCGA-BG-A220	UCEC	TCGA	NSYKSAYSPSP	CBL_PTK	0.1111
p.R273C	DO41784	UCEC	ICGC	NSYKSAYSPSP	CBL_PTK	0.1111
p.R273C	SIDM00813	Non-Cancerous	GDSC	NSYKSAYSPSP	CBL_PTK	0.1111
p.R273C	ACH-001182	Unknown	CCLE	NSYKSAYSPSP	CBL_PTK	0.1111
p.R273C	RPMI-6666	haematopoietic_and_lymphoid_tissue	COSMIC	NSYKSAYSPSP	CBL_PTK	0.1111
p.P271R	TCGA-FJ-A3ZF	BLCA	TCGA	NSYKSAYSPSP	CBL_PTK	0.0556
p.P271R	DO500	BLCA	ICGC	NSYKSAYSPSP	CBL_PTK	0.0556
p.S290N	DO222404	BTCA	ICGC	NSYKSAYSPSP	CBL_PTK	0.5958
p.S282F	DO222653	MELA	ICGC	NSYKSAYSPSP	CBL_PTK	0.6871
p.S282F	DO229491	SKCA	ICGC	NSYKSAYSPSP	CBL_PTK	0.6871
p.S285R	DO222843	MELA	ICGC	NSYKSAYSPSP	CBL_PTK	0.6316
p.D298N	DO229446	SKCA	ICGC	NSYKSAYSPSP	CBL_PTK	0.1389
p.P271A	SIDM01265	Plasma Cell Myeloma	GDSC	NSYKSAYSPSP	CBL_PTK	0.0556
p.P271A	SIDM00672	Hepatocellular Carcinoma	GDSC	NSYKSAYSPSP	CBL_PTK	0.0556
p.P271A	SIDM00330	Neuroblastoma	GDSC	NSYKSAYSPSP	CBL_PTK	0.0556
p.P271A	SIDM00082	Melanoma	GDSC	NSYKSAYSPSP	CBL_PTK	0.0556
p.P271A	SIDM00633	Breast Carcinoma	GDSC	NSYKSAYSPSP	CBL_PTK	0.0556
p.P271A	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	NSYKSAYSPSP	CBL_PTK	0.0556
p.P271A	SIDM00254	Neuroblastoma	GDSC	NSYKSAYSPSP	CBL_PTK	0.0556
p.P271A	SIDM00844	Burkitt's Lymphoma	GDSC	NSYKSAYSPSP	CBL_PTK	0.0556
p.P271A	SIDM00793	Burkitt's Lymphoma	GDSC	NSYKSAYSPSP	CBL_PTK	0.0556
p.P271A	SIDM00863	Burkitt's Lymphoma	GDSC	NSYKSAYSPSP	CBL_PTK	0.0556
p.P271A	SIDM00257	Neuroblastoma	GDSC	NSYKSAYSPSP	CBL_PTK	0.0556
p.P271A	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	NSYKSAYSPSP	CBL_PTK	0.0556
p.P294R	SIDM00879	Breast Carcinoma	GDSC	NSYKSAYSPSP	CBL_PTK	0.25
p.P294R	ACH-000349	Breast Cancer	CCLE	NSYKSAYSPSP	CBL_PTK	0.25
p.P294R	HCC1500	breast	COSMIC	NSYKSAYSPSP	CBL_PTK	0.25
p.Y287C	ACH-001389	Breast Cancer	CCLE	NSYKSAYSPSP	CBL_PTK	0.7087
p.V284A	GMS-10	central_nervous_system	COSMIC	NSYKSAYSPSP	CBL_PTK	0.6936
p.R278Q	MES-SA	soft_tissue	COSMIC	NSYKSAYSPSP	CBL_PTK	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NSYKSAYSPSP

Degron related mutations and impact score

Drug responses associated with DMRT2 mutations

All proteins holding degron of NSYKSAYSPSP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5R5	Doublesex- and mab-3-related transcription factor 2	CBL_PTK	281:291	NSYKSAYSPSP	CBL	0.951	More...