NOX1
UniProt ID: Q9Y5S8
Entrez ID: 27035
Protein name: NADPH oxidase 1 (NOX-1) (EC 1.-.-.-) (Mitogenic oxidase 1) (MOX-1) (NADH/NADPH mitogenic oxidase subunit P65-MOX) (NOH-1)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(...
FUNCTION: NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain.
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GO - Biological processes (BP):
angiogenesis [GO:0001525]; cell migration [GO:0016477]; cellular response to hyperoxia [GO:0071455]; cellular stress response to acidic pH [GO:1990451]; defense response [GO:0006952]; extracellular matrix organization [GO:0030198]; hydrogen peroxide metabolic process [GO:0042743]; inflammatory respo...
angiogenesis [GO:0001525]; cell migration [GO:0016477]; cellular response to hyperoxia [GO:0071455]; cellular stress response to acidic pH [GO:1990451]; defense response [GO:0006952]; extracellular matrix organization [GO:0030198]; hydrogen peroxide metabolic process [GO:0042743]; inflammatory response [GO:0006954]; intracellular pH elevation [GO:0051454]; NADP metabolic process [GO:0006739]; oxygen metabolic process [GO:0072592]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of integrin biosynthetic process [GO:0045726]; positive regulation of JNK cascade [GO:0046330]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of blood pressure [GO:0008217]; regulation of ion transmembrane transport [GO:0034765]; regulation of systemic arterial blood pressure by renin-angiotensin [GO:0003081]; respiratory burst [GO:0045730]; signal transduction [GO:0007165]; superoxide anion generation [GO:0042554]
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GO - Molecular function (MF):
metal ion binding [GO:0046872]; NADP binding [GO:0050661]; small GTPase binding [GO:0031267]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]; voltage-gated ion channel activity [GO:0005244]...
metal ion binding [GO:0046872]; NADP binding [GO:0050661]; small GTPase binding [GO:0031267]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]; voltage-gated ion channel activity [GO:0005244]
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GO - Cellular component (CC):
cell junction [GO:0030054]; cell projection [GO:0042995]; early endosome [GO:0005769]; NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886]...
cell junction [GO:0030054]; cell projection [GO:0042995]; early endosome [GO:0005769]; NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886]
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NOX1
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Kaplan plot for NOX1 in
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*NOTE: the Kaplan plots were collected from OncoLnc