DegronMD

Uniprot ID: Q9Y5S8

Source protein: NADPH oxidase 1

Source gene: NOX1

Class: DEG_APCC_KENBOX_2

Location: 560:564

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9983

ASA_SCORE: 68.7

COIL: 0.7382

CONS_SCORE: 0.5837

DSS_SCORE: 0.6447

HELIX: 0.0132

FCONS_SCORE: 2.117

RIG_SCORE: 0.8102

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K561N	TCGA-AJ-A3EL	UCEC	TCGA	NKENF	DEG_APCC_KENBOX_2	0.6918
p.K561N	TCGA-B5-A3FA	UCEC	TCGA	NKENF	DEG_APCC_KENBOX_2	0.6918
p.K561N	DO52402	UCEC	ICGC	NKENF	DEG_APCC_KENBOX_2	0.6918
p.K561N	DO41542	UCEC	ICGC	NKENF	DEG_APCC_KENBOX_2	0.6918
p.F564C	TCGA-BS-A0UF	UCEC	TCGA	NKENF	DEG_APCC_KENBOX_2	0.5996
p.F564C	TCGA-EO-A3AY	UCEC	TCGA	NKENF	DEG_APCC_KENBOX_2	0.5996
p.E562D	TCGA-CR-7395	HNSC	TCGA	NKENF	DEG_APCC_KENBOX_2	0.6758

DegronMD: protein-targeted degradation, mutation and drug response to degrons