DegronMD

Uniprot ID: P04839

Source protein: Cytochrome b-245 heavy chain

Source gene: CYBB

Class: DEG_APCC_KENBOX_2

Location: 566:570

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9935

ASA_SCORE: 71.8

COIL: 0.7756

CONS_SCORE: 0.6797

DSS_SCORE: 0.7365

HELIX: 0.0118

FCONS_SCORE: 1.9169

RIG_SCORE: 0.78

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F570L	TCGA-A5-A0G1	UCEC	TCGA	NKENF	DEG_APCC_KENBOX_2	0.587
p.F570L	TCGA-AJ-A5DW	UCEC	TCGA	NKENF	DEG_APCC_KENBOX_2	0.587
p.F570L	DO50075	UCEC	ICGC	NKENF	DEG_APCC_KENBOX_2	0.587
p.F570L	DO42472	UCEC	ICGC	NKENF	DEG_APCC_KENBOX_2	0.587
p.G560E	DO220889	MELA	ICGC	NKENF	DEG_APCC_KENBOX_2	0.1667
p.N566K	DO35088	PACA	ICGC	NKENF	DEG_APCC_KENBOX_2	0.5806
p.V561M	SIDM01259	B-Lymphoblastic Leukemia	GDSC	NKENF	DEG_APCC_KENBOX_2	0.1944
p.V561M	SIDM00271	Gastric Carcinoma	GDSC	NKENF	DEG_APCC_KENBOX_2	0.1944
p.V561M	ACH-000351	Gastric Cancer	CCLE	NKENF	DEG_APCC_KENBOX_2	0.1944
p.V561M	ACH-001669	Leukemia	CCLE	NKENF	DEG_APCC_KENBOX_2	0.1944
p.V561M	ACH-002238	Leukemia	CCLE	NKENF	DEG_APCC_KENBOX_2	0.1944
p.V561M	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	NKENF	DEG_APCC_KENBOX_2	0.1944
p.V561M	MKN1	stomach	COSMIC	NKENF	DEG_APCC_KENBOX_2	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons