DegronMD - Q8WXH2(JPH3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K231R	TCGA-13-0755	OV	TCGA	RRSLLSGLK	DEG_APCC_DBOX_1	216:224	Mutation substituting flanking lysine	0.25
p.K231R	DO28056	OV	ICGC	RRSLLSGLK	DEG_APCC_DBOX_1	216:224	Mutation substituting flanking lysine	0.25
p.R217C	TCGA-2W-A8YY	CESC	TCGA	RRSLLSGLK	DEG_APCC_DBOX_1	216:224	Mutation altering degron motif	0.8301
p.R217C	DO223732	CESC	ICGC	RRSLLSGLK	DEG_APCC_DBOX_1	216:224	Mutation altering degron motif	0.8301
p.K463N	TCGA-43-2581	LUSC	TCGA	LTPDDS	DEG_SCF_FBW7_1	470:475	Mutation substituting flanking lysine	0.25
p.K463N	DO26602	LUSC	ICGC	LTPDDS	DEG_SCF_FBW7_1	470:475	Mutation substituting flanking lysine	0.25
p.G222V	TCGA-97-7937	LUAD	TCGA	RRSLLSGLK	DEG_APCC_DBOX_1	216:224	Mutation altering degron motif	0.6421
p.G222V	DO25649	LUAD	ICGC	RRSLLSGLK	DEG_APCC_DBOX_1	216:224	Mutation altering degron motif	0.6421
p.A485V	TCGA-CK-6746	COAD	TCGA	LTPDDS	DEG_SCF_FBW7_1	470:475	Mutation rewiring degron network	0.0556
p.A485V	DO7938	COAD	ICGC	LTPDDS	DEG_SCF_FBW7_1	470:475	Mutation rewiring degron network	0.0556
p.D469Y	TCGA-F5-6814	READ	TCGA	LTPDDS	DEG_SCF_FBW7_1	470:475	Mutation rewiring degron network	0.3056
p.D469Y	DO36556	READ	ICGC	LTPDDS	DEG_SCF_FBW7_1	470:475	Mutation rewiring degron network	0.3056
p.R216W	TCGA-FR-A7U9	SKCM	TCGA	RRSLLSGLK	DEG_APCC_DBOX_1	216:224	Mutation altering degron motif	0.7523
p.R216W	DO48546	SKCM	ICGC	RRSLLSGLK	DEG_APCC_DBOX_1	216:224	Mutation altering degron motif	0.7523
p.S468C	TCGA-S5-A6DX	BLCA	TCGA	LTPDDS	DEG_SCF_FBW7_1	470:475	Mutation rewiring degron network	0.2778
p.S468C	DO51903	BLCA	ICGC	LTPDDS	DEG_SCF_FBW7_1	470:475	Mutation rewiring degron network	0.2778
p.R226H	DO233158	GACA	ICGC	RRSLLSGLK	DEG_APCC_DBOX_1	216:224	Mutation rewiring degron network	0.2778
p.R226H	DO233168	GACA	ICGC	RRSLLSGLK	DEG_APCC_DBOX_1	216:224	Mutation rewiring degron network	0.2778
p.R656Q	DO233089	GACA	ICGC	NKENF	DEG_APCC_KENBOX_2	661:665	Mutation rewiring degron network	0.1944
p.G213V	DO229031	LICA	ICGC	RRSLLSGLK	DEG_APCC_DBOX_1	216:224	Mutation rewiring degron network	0.25
p.V652L	DO229006	LICA	ICGC	NKENF	DEG_APCC_KENBOX_2	661:665	Mutation rewiring degron network	0.0833
p.G222R	DO23450	LINC	ICGC	RRSLLSGLK	DEG_APCC_DBOX_1	216:224	Mutation altering degron motif	0.6457
p.P667L	DO231047	LUSC	ICGC	NKENF	DEG_APCC_KENBOX_2	661:665	Mutation rewiring degron network	0.2778
p.S670F	DO220859	MELA	ICGC	NKENF	DEG_APCC_KENBOX_2	661:665	Mutation rewiring degron network	0.1944
p.P472T	DO229166	NKTL	ICGC	LTPDDS	DEG_SCF_FBW7_1	470:475	Mutation altering degron motif	0.7031
p.A671T	DO32817	PACA	ICGC	NKENF	DEG_APCC_KENBOX_2	661:665	Mutation rewiring degron network	0.1667
p.A671T	SIDM01135	Pancreatic Carcinoma	GDSC	NKENF	DEG_APCC_KENBOX_2	661:665	Mutation rewiring degron network	0.1667
p.A671T	ACH-000060	Pancreatic Cancer	CCLE	NKENF	DEG_APCC_KENBOX_2	661:665	Mutation rewiring degron network	0.1667
p.A671T	PANC-10-05	pancreas	COSMIC	NKENF	DEG_APCC_KENBOX_2	661:665	Mutation rewiring degron network	0.1667
p.S670P	DO232224	PBCA	ICGC	NKENF	DEG_APCC_KENBOX_2	661:665	Mutation rewiring degron network	0.1944
p.R656W	SIDM00908	Non-Cancerous	GDSC	NKENF	DEG_APCC_KENBOX_2	661:665	Mutation rewiring degron network	0.1944
p.R656W	SIDM00532	Glioma	GDSC	NKENF	DEG_APCC_KENBOX_2	661:665	Mutation rewiring degron network	0.1944
p.S209T	SIDM01218	Other Solid Cancers	GDSC	RRSLLSGLK	DEG_APCC_DBOX_1	216:224	Mutation rewiring degron network	0.1389
p.S209T	SIDM00156	Neuroblastoma	GDSC	RRSLLSGLK	DEG_APCC_DBOX_1	216:224	Mutation rewiring degron network	0.1389
p.S209T	SIDM01113	Other Sarcomas	GDSC	RRSLLSGLK	DEG_APCC_DBOX_1	216:224	Mutation rewiring degron network	0.1389
p.S209T	SIDM00050	Chondrosarcoma	GDSC	RRSLLSGLK	DEG_APCC_DBOX_1	216:224	Mutation rewiring degron network	0.1389
p.S228L	SIDM00534	Colorectal Carcinoma	GDSC	RRSLLSGLK	DEG_APCC_DBOX_1	216:224	Mutation blocking phosphorylation signal	0.6667
p.S228L	ACH-000986	Colon/Colorectal Cancer	CCLE	RRSLLSGLK	DEG_APCC_DBOX_1	216:224	Mutation blocking phosphorylation signal	0.6667
p.S228L	HT-115	large intestine	COSMIC	RRSLLSGLK	DEG_APCC_DBOX_1	216:224	Mutation blocking phosphorylation signal	0.6667
p.D473N	ACH-000932	Gastric Cancer	CCLE	LTPDDS	DEG_SCF_FBW7_1	470:475	Mutation altering degron motif	0.5821
p.R654T	ACH-001556	Lung Cancer	CCLE	NKENF	DEG_APCC_KENBOX_2	661:665	Mutation rewiring degron network	0.1389
p.D469N	ACH-001568	Skin Cancer	CCLE	LTPDDS	DEG_SCF_FBW7_1	470:475	Mutation rewiring degron network	0.3056

Kaplan plot for JPH3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

JPH3

UniProt ID: Q8WXH2

Entrez ID: 57338

Protein name: Junctophilin-3 (JP-3) (Junctophilin type 3) (Trinucleotide repeat-containing gene 22 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for JPH3 in