DegronMD

Uniprot ID: Q8WXH2

Source protein: Junctophilin-3

Source gene: JPH3

Class: DEG_SCF_FBW7_1

Location: 470:475

E3 ligase: FBXW7

DEGRON score: 0.9782

ASA_SCORE: 73.0167

COIL: 0.8502

CONS_SCORE: 0.3222

DSS_SCORE: 0.7569

HELIX: 0.1295

FCONS_SCORE: 1.0327

RIG_SCORE: 0.6239

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K463N	TCGA-43-2581	LUSC	TCGA	LTPDDS	DEG_SCF_FBW7_1	0.25
p.K463N	DO26602	LUSC	ICGC	LTPDDS	DEG_SCF_FBW7_1	0.25
p.A485V	TCGA-CK-6746	COAD	TCGA	LTPDDS	DEG_SCF_FBW7_1	0.0556
p.A485V	DO7938	COAD	ICGC	LTPDDS	DEG_SCF_FBW7_1	0.0556
p.D469Y	TCGA-F5-6814	READ	TCGA	LTPDDS	DEG_SCF_FBW7_1	0.3056
p.D469Y	DO36556	READ	ICGC	LTPDDS	DEG_SCF_FBW7_1	0.3056
p.S468C	TCGA-S5-A6DX	BLCA	TCGA	LTPDDS	DEG_SCF_FBW7_1	0.2778
p.S468C	DO51903	BLCA	ICGC	LTPDDS	DEG_SCF_FBW7_1	0.2778
p.P472T	DO229166	NKTL	ICGC	LTPDDS	DEG_SCF_FBW7_1	0.7031
p.D473N	ACH-000932	Gastric Cancer	CCLE	LTPDDS	DEG_SCF_FBW7_1	0.5821
p.D469N	ACH-001568	Skin Cancer	CCLE	LTPDDS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13255	Metabotropic glutamate receptor 1	DEG_SCF_FBW7_1	1137:1142	LTPDDS	FBXW7	0.9004	More...
Q8WXH2	Junctophilin-3	DEG_SCF_FBW7_1	470:475	LTPDDS	FBXW7	0.9782	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons