DegronMD

Uniprot ID: Q13255

Source protein: Metabotropic glutamate receptor 1

Source gene: GRM1

Class: DEG_SCF_FBW7_1

Location: 1137:1142

E3 ligase: FBXW7

DEGRON score: 0.9004

ASA_SCORE: 63.7667

COIL: 0.814

CONS_SCORE: 0.2653

DSS_SCORE: 0.7713

HELIX: 0.1672

FCONS_SCORE: 0.9959

RIG_SCORE: 0.6232

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1130Y	TCGA-2V-A95S	LIHC	TCGA	LTPDDS	DEG_SCF_FBW7_1	0.1389
p.D1130Y	DO223911	LIHC	ICGC	LTPDDS	DEG_SCF_FBW7_1	0.1389
p.E1128K	TCGA-5L-AAT1	BRCA	TCGA	LTPDDS	DEG_SCF_FBW7_1	0.0833
p.E1128K	TCGA-77-8143	LUSC	TCGA	LTPDDS	DEG_SCF_FBW7_1	0.0833
p.E1128K	DO219594	BRCA	ICGC	LTPDDS	DEG_SCF_FBW7_1	0.0833
p.E1128K	DO27247	LUSC	ICGC	LTPDDS	DEG_SCF_FBW7_1	0.0833
p.D1141N	TCGA-77-7337	LUSC	TCGA	LTPDDS	DEG_SCF_FBW7_1	0.5821
p.D1141N	TCGA-97-7546	LUAD	TCGA	LTPDDS	DEG_SCF_FBW7_1	0.5821
p.D1141N	DO23762	LUAD	ICGC	LTPDDS	DEG_SCF_FBW7_1	0.5821
p.D1141N	DO27445	LUSC	ICGC	LTPDDS	DEG_SCF_FBW7_1	0.5821
p.R1152H	TCGA-AX-A2HC	UCEC	TCGA	LTPDDS	DEG_SCF_FBW7_1	0.0556
p.R1152H	DO50385	ESAD	ICGC	LTPDDS	DEG_SCF_FBW7_1	0.0556
p.R1152H	DO232761	PBCA	ICGC	LTPDDS	DEG_SCF_FBW7_1	0.0556
p.R1152H	DO41572	UCEC	ICGC	LTPDDS	DEG_SCF_FBW7_1	0.0556
p.S1149L	TCGA-BA-6869	HNSC	TCGA	LTPDDS	DEG_SCF_FBW7_1	0.1389
p.S1149L	DO14250	HNSC	ICGC	LTPDDS	DEG_SCF_FBW7_1	0.1389
p.P1143H	TCGA-CG-4306	STAD	TCGA	LTPDDS	DEG_SCF_FBW7_1	0.3056
p.P1143H	DO38567	STAD	ICGC	LTPDDS	DEG_SCF_FBW7_1	0.3056
p.E1127V	TCGA-CN-A63U	HNSC	TCGA	LTPDDS	DEG_SCF_FBW7_1	0.0556
p.E1127V	DO44454	HNSC	ICGC	LTPDDS	DEG_SCF_FBW7_1	0.0556
p.P1143S	TCGA-CR-7398	HNSC	TCGA	LTPDDS	DEG_SCF_FBW7_1	0.3056
p.P1143S	DO14782	HNSC	ICGC	LTPDDS	DEG_SCF_FBW7_1	0.3056
p.A1144V	TCGA-D1-A103	UCEC	TCGA	LTPDDS	DEG_SCF_FBW7_1	0.2778
p.A1144V	TCGA-EO-A22R	UCEC	TCGA	LTPDDS	DEG_SCF_FBW7_1	0.2778
p.A1144V	DO227609	COCA	ICGC	LTPDDS	DEG_SCF_FBW7_1	0.2778
p.A1144V	DO52652	MALY	ICGC	LTPDDS	DEG_SCF_FBW7_1	0.2778
p.A1144V	DO42312	UCEC	ICGC	LTPDDS	DEG_SCF_FBW7_1	0.2778
p.A1144V	DO42713	UCEC	ICGC	LTPDDS	DEG_SCF_FBW7_1	0.2778
p.R1152S	TCGA-EE-A2MS	SKCM	TCGA	LTPDDS	DEG_SCF_FBW7_1	0.0556
p.R1152S	DO37567	SKCM	ICGC	LTPDDS	DEG_SCF_FBW7_1	0.0556
p.A1133V	TCGA-R6-A8WC	ESCA	TCGA	LTPDDS	DEG_SCF_FBW7_1	0.2222
p.T1146M	DO222383	BTCA	ICGC	LTPDDS	DEG_SCF_FBW7_1	0.2222
p.P1139Q	DO233737	GACA	ICGC	LTPDDS	DEG_SCF_FBW7_1	0.7035
p.A1144G	DO46850	RECA	ICGC	LTPDDS	DEG_SCF_FBW7_1	0.2778
p.P1148S	SIDM01175	Other Sarcomas	GDSC	LTPDDS	DEG_SCF_FBW7_1	0.1667
p.P1148S	ACH-002309	Sarcoma	CCLE	LTPDDS	DEG_SCF_FBW7_1	0.1667
p.P1148S	SW684	soft_tissue	COSMIC	LTPDDS	DEG_SCF_FBW7_1	0.1667
p.E1127D	SIDM00889	Cervical Carcinoma	GDSC	LTPDDS	DEG_SCF_FBW7_1	0.0556
p.E1127D	ACH-001333	Cervical Cancer	CCLE	LTPDDS	DEG_SCF_FBW7_1	0.0556
p.E1127D	C-33-A	cervix	COSMIC	LTPDDS	DEG_SCF_FBW7_1	0.0556
p.D1130V	SIDM00282	Colorectal Carcinoma	GDSC	LTPDDS	DEG_SCF_FBW7_1	0.1389
p.D1130V	ACH-000998	Colon/Colorectal Cancer	CCLE	LTPDDS	DEG_SCF_FBW7_1	0.1389
p.D1130V	CW-2	large_intestine	COSMIC	LTPDDS	DEG_SCF_FBW7_1	0.1389
p.D1141G	SIDM00537	Colorectal Carcinoma	GDSC	LTPDDS	DEG_SCF_FBW7_1	0.6087
p.D1141G	ACH-000982	Colon/Colorectal Cancer	CCLE	LTPDDS	DEG_SCF_FBW7_1	0.6087
p.D1141G	ACH-001345	Colon/Colorectal Cancer	CCLE	LTPDDS	DEG_SCF_FBW7_1	0.6087
p.D1141G	GP5d	large_intestine	COSMIC	LTPDDS	DEG_SCF_FBW7_1	0.6087
p.T1146K	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	LTPDDS	DEG_SCF_FBW7_1	0.2222
p.T1146K	ACH-000951	Lung Cancer	CCLE	LTPDDS	DEG_SCF_FBW7_1	0.2222
p.T1146K	NCI-H2342	lung	COSMIC	LTPDDS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13255	Metabotropic glutamate receptor 1	DEG_SCF_FBW7_1	1137:1142	LTPDDS	FBXW7	0.9004	More...
Q8WXH2	Junctophilin-3	DEG_SCF_FBW7_1	470:475	LTPDDS	FBXW7	0.9782	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPDDS

Degron related mutations and impact score

Drug responses associated with GRM1 mutations

All proteins holding degron of LTPDDS