DegronMD

Uniprot ID: Q8WXH2

Source protein: Junctophilin-3

Source gene: JPH3

Class: DEG_APCC_DBOX_1

Location: 216:224

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8646

ASA_SCORE: 85.2333

COIL: 0.5648

CONS_SCORE: 0.4176

DSS_SCORE: 0.3203

HELIX: 0.0261

FCONS_SCORE: 1.2215

RIG_SCORE: 0.7756

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K231R	TCGA-13-0755	OV	TCGA	RRSLLSGLK	DEG_APCC_DBOX_1	0.25
p.K231R	DO28056	OV	ICGC	RRSLLSGLK	DEG_APCC_DBOX_1	0.25
p.R217C	TCGA-2W-A8YY	CESC	TCGA	RRSLLSGLK	DEG_APCC_DBOX_1	0.8301
p.R217C	DO223732	CESC	ICGC	RRSLLSGLK	DEG_APCC_DBOX_1	0.8301
p.G222V	TCGA-97-7937	LUAD	TCGA	RRSLLSGLK	DEG_APCC_DBOX_1	0.6421
p.G222V	DO25649	LUAD	ICGC	RRSLLSGLK	DEG_APCC_DBOX_1	0.6421
p.R216W	TCGA-FR-A7U9	SKCM	TCGA	RRSLLSGLK	DEG_APCC_DBOX_1	0.7523
p.R216W	DO48546	SKCM	ICGC	RRSLLSGLK	DEG_APCC_DBOX_1	0.7523
p.R226H	DO233158	GACA	ICGC	RRSLLSGLK	DEG_APCC_DBOX_1	0.2778
p.R226H	DO233168	GACA	ICGC	RRSLLSGLK	DEG_APCC_DBOX_1	0.2778
p.G213V	DO229031	LICA	ICGC	RRSLLSGLK	DEG_APCC_DBOX_1	0.25
p.G222R	DO23450	LINC	ICGC	RRSLLSGLK	DEG_APCC_DBOX_1	0.6457
p.S209T	SIDM01218	Other Solid Cancers	GDSC	RRSLLSGLK	DEG_APCC_DBOX_1	0.1389
p.S209T	SIDM00156	Neuroblastoma	GDSC	RRSLLSGLK	DEG_APCC_DBOX_1	0.1389
p.S209T	SIDM01113	Other Sarcomas	GDSC	RRSLLSGLK	DEG_APCC_DBOX_1	0.1389
p.S209T	SIDM00050	Chondrosarcoma	GDSC	RRSLLSGLK	DEG_APCC_DBOX_1	0.1389
p.S228L	SIDM00534	Colorectal Carcinoma	GDSC	RRSLLSGLK	DEG_APCC_DBOX_1	0.6667
p.S228L	ACH-000986	Colon/Colorectal Cancer	CCLE	RRSLLSGLK	DEG_APCC_DBOX_1	0.6667
p.S228L	HT-115	large_intestine	COSMIC	RRSLLSGLK	DEG_APCC_DBOX_1	0.6667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXH2	Junctophilin-3	DEG_APCC_DBOX_1	216:224	RRSLLSGLK	APC,CDC20,FZR1	0.8646	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons