DegronMD

Uniprot ID: Q8WXH2

Source protein: Junctophilin-3

Source gene: JPH3

Class: DEG_APCC_KENBOX_2

Location: 661:665

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5688

ASA_SCORE: 105.58

COIL: 0.7494

CONS_SCORE: 0.2947

DSS_SCORE: 0.6348

HELIX: 0.2246

FCONS_SCORE: 0.9548

RIG_SCORE: 0.6663

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R656Q	DO233089	GACA	ICGC	NKENF	DEG_APCC_KENBOX_2	0.1944
p.V652L	DO229006	LICA	ICGC	NKENF	DEG_APCC_KENBOX_2	0.0833
p.P667L	DO231047	LUSC	ICGC	NKENF	DEG_APCC_KENBOX_2	0.2778
p.S670F	DO220859	MELA	ICGC	NKENF	DEG_APCC_KENBOX_2	0.1944
p.A671T	DO32817	PACA	ICGC	NKENF	DEG_APCC_KENBOX_2	0.1667
p.A671T	SIDM01135	Pancreatic Carcinoma	GDSC	NKENF	DEG_APCC_KENBOX_2	0.1667
p.A671T	ACH-000060	Pancreatic Cancer	CCLE	NKENF	DEG_APCC_KENBOX_2	0.1667
p.A671T	PANC-10-05	pancreas	COSMIC	NKENF	DEG_APCC_KENBOX_2	0.1667
p.S670P	DO232224	PBCA	ICGC	NKENF	DEG_APCC_KENBOX_2	0.1944
p.R656W	SIDM00908	Non-Cancerous	GDSC	NKENF	DEG_APCC_KENBOX_2	0.1944
p.R656W	SIDM00532	Glioma	GDSC	NKENF	DEG_APCC_KENBOX_2	0.1944
p.R654T	ACH-001556	Lung Cancer	CCLE	NKENF	DEG_APCC_KENBOX_2	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons