DNAJC15
UniProt ID: Q9Y5T4
Entrez ID: 29103
Protein name: DnaJ homolog subfamily C member 15 (Cell growth-inhibiting gene 22 protein) (Methylation-controlled J protein) (MCJ)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9. {ECO:0000250, ECO:...
FUNCTION: Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9. {ECO:0000250, ECO:0000269|PubMed:23263864}.
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GO - Biological processes (BP):
cellular response to starvation [GO:0009267]; intracellular protein transport [GO:0006886]; negative regulation of mitochondrial electron transport, NADH to ubiquinone [GO:1902957]; negative regulation of protein-containing complex assembly [GO:0031333]; protein import into mitochondrial matrix [GO:...
cellular response to starvation [GO:0009267]; intracellular protein transport [GO:0006886]; negative regulation of mitochondrial electron transport, NADH to ubiquinone [GO:1902957]; negative regulation of protein-containing complex assembly [GO:0031333]; protein import into mitochondrial matrix [GO:0030150]; regulation of lipid metabolic process [GO:0019216]
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GO - Molecular function (MF):
ATPase activator activity [GO:0001671]...
ATPase activator activity [GO:0001671]
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GO - Cellular component (CC):
integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; PAM complex, Tim23 associated import motor [GO:0001405]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]...
integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; PAM complex, Tim23 associated import motor [GO:0001405]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]
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DNAJC15
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*NOTE: the Kaplan plots were collected from OncoLnc