DegronMD

Uniprot ID: Q9Y5T4

Source protein: DnaJ homolog subfamily C member 15

Source gene: DNAJC15

Class: DEG_SCF_FBW7_1

Location: 75:81

E3 ligase: FBXW7

DEGRON score: 0.7218

ASA_SCORE: 53.4857

COIL: 0.7759

CONS_SCORE: 0.4001

DSS_SCORE: 0.2294

HELIX: 0.1771

FCONS_SCORE: 0.7401

RIG_SCORE: 0.7709

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q90P	TCGA-A5-A0G2	UCEC	TCGA	ISTPSFS	DEG_SCF_FBW7_1	0.0833
p.Q90P	DO41235	UCEC	ICGC	ISTPSFS	DEG_SCF_FBW7_1	0.0833
p.A72V	TCGA-AX-A3G8	UCEC	TCGA	ISTPSFS	DEG_SCF_FBW7_1	0.25
p.A72V	DO41014	UCEC	ICGC	ISTPSFS	DEG_SCF_FBW7_1	0.25
p.T69R	TCGA-CG-5717	STAD	TCGA	ISTPSFS	DEG_SCF_FBW7_1	0.1667
p.T69R	DO38272	STAD	ICGC	ISTPSFS	DEG_SCF_FBW7_1	0.1667
p.Y83C	TCGA-ER-A19G	SKCM	TCGA	ISTPSFS	DEG_SCF_FBW7_1	0.7222
p.Y83C	DO47284	SKCM	ICGC	ISTPSFS	DEG_SCF_FBW7_1	0.7222
p.Q90H	DO225372	BRCA	ICGC	ISTPSFS	DEG_SCF_FBW7_1	0.0833
p.G87V	DO229028	LICA	ICGC	ISTPSFS	DEG_SCF_FBW7_1	0.1667
p.K74T	SIDM00855	Other Sarcomas	GDSC	ISTPSFS	DEG_SCF_FBW7_1	0.3056
p.K74T	SIDM00006	Other Solid Cancers	GDSC	ISTPSFS	DEG_SCF_FBW7_1	0.3056
p.P78A	NCI-H2347	lung	COSMIC	ISTPSFS	DEG_SCF_FBW7_1	0.7503

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5T4	DnaJ homolog subfamily C member 15	DEG_SCF_FBW7_1	75:81	ISTPSFS	FBXW7	0.7218	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons