DegronMD - Q9Y5W7(SNX14)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P735S	TCGA-37-3792	LUSC	TCGA	SRPELTILS	DEG_APCC_DBOX_1	740:748	Mutation rewiring degron network	0.1944
p.S748G	TCGA-AA-3821	COAD	TCGA	SRPELTILS	DEG_APCC_DBOX_1	740:748	Mutation altering degron motif	0.6993
p.P742S	TCGA-AP-A059	UCEC	TCGA	SRPELTILS	DEG_APCC_DBOX_1	740:748	Mutation altering degron motif	0.5641
p.N754S	TCGA-DU-6392	LGG	TCGA	SRPELTILS	DEG_APCC_DBOX_1	740:748	Mutation rewiring degron network	0.1667
p.S731F	SIDM01137	Pancreatic Carcinoma	GDSC	SRPELTILS	DEG_APCC_DBOX_1	740:748	Mutation rewiring degron network	0.0833
p.S731F	ACH-000235	Pancreatic Cancer	CCLE	SRPELTILS	DEG_APCC_DBOX_1	740:748	Mutation rewiring degron network	0.0833
p.S731F	PANC-04-03	pancreas	COSMIC	SRPELTILS	DEG_APCC_DBOX_1	740:748	Mutation rewiring degron network	0.0833
p.S734Y	SIDM01609	Endometrial Carcinoma	GDSC	SRPELTILS	DEG_APCC_DBOX_1	740:748	Mutation blocking phosphorylation signal	0.6111
p.S734Y	ACH-000972	Endometrial/Uterine Cancer	CCLE	SRPELTILS	DEG_APCC_DBOX_1	740:748	Mutation blocking phosphorylation signal	0.6111
p.H757P	NCI-H1092	lung	COSMIC	SRPELTILS	DEG_APCC_DBOX_1	740:748	Mutation rewiring degron network	0.0833
p.H758P	NCI-H1092	lung	COSMIC	SRPELTILS	DEG_APCC_DBOX_1	740:748	Mutation rewiring degron network	0.0556

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons