DegronMD

Uniprot ID: Q9Y5W7

Source protein: Sorting nexin-14

Source gene: SNX14

Class: DEG_APCC_DBOX_1

Location: 740:748

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9981

ASA_SCORE: 77.3111

COIL: 0.7387

CONS_SCORE: 0.3766

DSS_SCORE: 0.6343

HELIX: 0.1352

FCONS_SCORE: 1.0348

RIG_SCORE: 0.6923

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P735S	TCGA-37-3792	LUSC	TCGA	SRPELTILS	DEG_APCC_DBOX_1	0.1944
p.S748G	TCGA-AA-3821	COAD	TCGA	SRPELTILS	DEG_APCC_DBOX_1	0.6993
p.P742S	TCGA-AP-A059	UCEC	TCGA	SRPELTILS	DEG_APCC_DBOX_1	0.5641
p.N754S	TCGA-DU-6392	LGG	TCGA	SRPELTILS	DEG_APCC_DBOX_1	0.1667
p.S731F	SIDM01137	Pancreatic Carcinoma	GDSC	SRPELTILS	DEG_APCC_DBOX_1	0.0833
p.S731F	ACH-000235	Pancreatic Cancer	CCLE	SRPELTILS	DEG_APCC_DBOX_1	0.0833
p.S731F	PANC-04-03	pancreas	COSMIC	SRPELTILS	DEG_APCC_DBOX_1	0.0833
p.S734Y	SIDM01609	Endometrial Carcinoma	GDSC	SRPELTILS	DEG_APCC_DBOX_1	0.6111
p.S734Y	ACH-000972	Endometrial/Uterine Cancer	CCLE	SRPELTILS	DEG_APCC_DBOX_1	0.6111
p.H757P	NCI-H1092	lung	COSMIC	SRPELTILS	DEG_APCC_DBOX_1	0.0833
p.H758P	NCI-H1092	lung	COSMIC	SRPELTILS	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5W7	Sorting nexin-14	DEG_APCC_DBOX_1	740:748	SRPELTILS	APC,CDC20,FZR1	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons