DegronMD - Q9Y5X2(SNX8)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H448Q	TCGA-DD-A4NK	LIHC	TCGA	LTPPCS	DEG_SCF_FBW7_1	451:456	Mutation rewiring degron network	0.25
p.H448Q	DO44882	LIHC	ICGC	LTPPCS	DEG_SCF_FBW7_1	451:456	Mutation rewiring degron network	0.25
p.P458L	TCGA-EY-A1GF	UCEC	TCGA	LTPPCS	DEG_SCF_FBW7_1	451:456	Mutation rewiring degron network	0.2778
p.P458L	DO41704	UCEC	ICGC	LTPPCS	DEG_SCF_FBW7_1	451:456	Mutation rewiring degron network	0.2778
p.P447Q	DO229045	LICA	ICGC	LTPPCS	DEG_SCF_FBW7_1	451:456	Mutation rewiring degron network	0.2222
p.P454L	ACH-000294	Leukemia	CCLE	LTPPCS	DEG_SCF_FBW7_1	451:456	Mutation altering degron motif	0.6471
p.L462M	ACH-000969	Colon/Colorectal Cancer	CCLE	LTPPCS	DEG_SCF_FBW7_1	451:456	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons