DegronMD

Uniprot ID: Q9Y5X2

Source protein: Sorting nexin-8

Source gene: SNX8

Class: DEG_SCF_FBW7_1

Location: 451:456

E3 ligase: FBXW7

DEGRON score: 0.9637

ASA_SCORE: 79.8167

COIL: 0.968

CONS_SCORE: 0.3423

DSS_SCORE: 0.3708

HELIX: 0.0095

FCONS_SCORE: 0.9369

RIG_SCORE: 0.6294

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H448Q	TCGA-DD-A4NK	LIHC	TCGA	LTPPCS	DEG_SCF_FBW7_1	0.25
p.H448Q	DO44882	LIHC	ICGC	LTPPCS	DEG_SCF_FBW7_1	0.25
p.P458L	TCGA-EY-A1GF	UCEC	TCGA	LTPPCS	DEG_SCF_FBW7_1	0.2778
p.P458L	DO41704	UCEC	ICGC	LTPPCS	DEG_SCF_FBW7_1	0.2778
p.P447Q	DO229045	LICA	ICGC	LTPPCS	DEG_SCF_FBW7_1	0.2222
p.P454L	ACH-000294	Leukemia	CCLE	LTPPCS	DEG_SCF_FBW7_1	0.6471
p.L462M	ACH-000969	Colon/Colorectal Cancer	CCLE	LTPPCS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5X2	Sorting nexin-8	DEG_SCF_FBW7_1	451:456	LTPPCS	FBXW7	0.9637	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons