DegronMD - Q9Y623(MYH4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E1287K	TCGA-21-1079	LUSC	TCGA	KARLHTE	LIG_APCC_ABBAyCdc20_2	1281:1287	Mutation altering degron motif	0.7022
p.E1287K	TCGA-EB-A3XD	SKCM	TCGA	KARLHTE	LIG_APCC_ABBAyCdc20_2	1281:1287	Mutation altering degron motif	0.7022
p.E1287K	TCGA-EB-A44O	SKCM	TCGA	KARLHTE	LIG_APCC_ABBAyCdc20_2	1281:1287	Mutation altering degron motif	0.7022
p.E1287K	DO26846	LUSC	ICGC	KARLHTE	LIG_APCC_ABBAyCdc20_2	1281:1287	Mutation altering degron motif	0.7022
p.E1287K	DO37871	SKCM	ICGC	KARLHTE	LIG_APCC_ABBAyCdc20_2	1281:1287	Mutation altering degron motif	0.7022
p.E1287K	DO47272	SKCM	ICGC	KARLHTE	LIG_APCC_ABBAyCdc20_2	1281:1287	Mutation altering degron motif	0.7022
p.E1290D	TCGA-44-7662	LUAD	TCGA	KARLHTE	LIG_APCC_ABBAyCdc20_2	1281:1287	Mutation rewiring degron network	0.25
p.E1290D	DO23597	LUAD	ICGC	KARLHTE	LIG_APCC_ABBAyCdc20_2	1281:1287	Mutation rewiring degron network	0.25
p.G1289V	TCGA-91-A4BC	LUAD	TCGA	KARLHTE	LIG_APCC_ABBAyCdc20_2	1281:1287	Mutation rewiring degron network	0.2778
p.G1289V	DO45422	LUAD	ICGC	KARLHTE	LIG_APCC_ABBAyCdc20_2	1281:1287	Mutation rewiring degron network	0.2778
p.R1272C	TCGA-D6-6516	HNSC	TCGA	KARLHTE	LIG_APCC_ABBAyCdc20_2	1281:1287	Mutation rewiring degron network	0.0833
p.R1272C	TCGA-FP-A4BE	STAD	TCGA	KARLHTE	LIG_APCC_ABBAyCdc20_2	1281:1287	Mutation rewiring degron network	0.0833
p.R1272C	DO15623	HNSC	ICGC	KARLHTE	LIG_APCC_ABBAyCdc20_2	1281:1287	Mutation rewiring degron network	0.0833
p.R1272C	DO48016	STAD	ICGC	KARLHTE	LIG_APCC_ABBAyCdc20_2	1281:1287	Mutation rewiring degron network	0.0833
p.E1297K	TCGA-EB-A6QZ	SKCM	TCGA	KARLHTE	LIG_APCC_ABBAyCdc20_2	1281:1287	Mutation rewiring degron network	0.0556
p.E1297K	TCGA-GF-A6C9	SKCM	TCGA	KARLHTE	LIG_APCC_ABBAyCdc20_2	1281:1287	Mutation rewiring degron network	0.0556
p.E1297K	DO222708	MELA	ICGC	KARLHTE	LIG_APCC_ABBAyCdc20_2	1281:1287	Mutation rewiring degron network	0.0556
p.E1297K	DO222898	MELA	ICGC	KARLHTE	LIG_APCC_ABBAyCdc20_2	1281:1287	Mutation rewiring degron network	0.0556
p.E1297K	DO48626	SKCM	ICGC	KARLHTE	LIG_APCC_ABBAyCdc20_2	1281:1287	Mutation rewiring degron network	0.0556
p.E1297K	DO51254	SKCM	ICGC	KARLHTE	LIG_APCC_ABBAyCdc20_2	1281:1287	Mutation rewiring degron network	0.0556
p.H1285R	DO228359	LICA	ICGC	KARLHTE	LIG_APCC_ABBAyCdc20_2	1281:1287	Mutation altering degron motif	0.8244
p.T1286K	DO229041	LICA	ICGC	KARLHTE	LIG_APCC_ABBAyCdc20_2	1281:1287	Mutation altering degron motif	0.7306
p.S1292L	DO218908	SKCA	ICGC	KARLHTE	LIG_APCC_ABBAyCdc20_2	1281:1287	Mutation blocking phosphorylation signal	0.6389
p.D1296H	SIDM00590	Oral Cavity Carcinoma	GDSC	KARLHTE	LIG_APCC_ABBAyCdc20_2	1281:1287	Mutation rewiring degron network	0.0833
p.D1296H	SIDM00792	Small Cell Lung Carcinoma	GDSC	KARLHTE	LIG_APCC_ABBAyCdc20_2	1281:1287	Mutation rewiring degron network	0.0833
p.D1296H	ACH-000472	Head and Neck Cancer	CCLE	KARLHTE	LIG_APCC_ABBAyCdc20_2	1281:1287	Mutation rewiring degron network	0.0833
p.D1296H	ACH-002170	Lung Cancer	CCLE	KARLHTE	LIG_APCC_ABBAyCdc20_2	1281:1287	Mutation rewiring degron network	0.0833
p.D1296H	HSC-2	upper aerodigestive tract	COSMIC	KARLHTE	LIG_APCC_ABBAyCdc20_2	1281:1287	Mutation rewiring degron network	0.0833
p.D1296H	NCI-H1688	lung	COSMIC	KARLHTE	LIG_APCC_ABBAyCdc20_2	1281:1287	Mutation rewiring degron network	0.0833

Kaplan plot for MYH4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYH4

UniProt ID: Q9Y623

Entrez ID: 4622

Protein name: Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYH4 in