DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
KARLHTE
Uniprot ID:
Q9Y623
Source protein:
Myosin-4
Source gene:
MYH4
Class:
LIG_APCC_ABBAyCdc20_2
Location:
1281:1287
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.75
ASA_SCORE:
91.3286
COIL:
0.0319
CONS_SCORE:
0.3767
DSS_SCORE:
0.4747
HELIX:
0.969
FCONS_SCORE:
0.9876
RIG_SCORE:
0.6933
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.H1285R
DO228359
LICA
ICGC
KARLHTE
LIG_APCC_ABBAyCdc20_2
0.8244
p.T1286K
DO229041
LICA
ICGC
KARLHTE
LIG_APCC_ABBAyCdc20_2
0.7306
p.E1287K
TCGA-21-1079
LUSC
TCGA
KARLHTE
LIG_APCC_ABBAyCdc20_2
0.7022
p.E1287K
TCGA-EB-A3XD
SKCM
TCGA
KARLHTE
LIG_APCC_ABBAyCdc20_2
0.7022
p.E1287K
TCGA-EB-A44O
SKCM
TCGA
KARLHTE
LIG_APCC_ABBAyCdc20_2
0.7022
p.E1287K
DO26846
LUSC
ICGC
KARLHTE
LIG_APCC_ABBAyCdc20_2
0.7022
p.E1287K
DO37871
SKCM
ICGC
KARLHTE
LIG_APCC_ABBAyCdc20_2
0.7022
p.E1287K
DO47272
SKCM
ICGC
KARLHTE
LIG_APCC_ABBAyCdc20_2
0.7022
p.S1292L
DO218908
SKCA
ICGC
KARLHTE
LIG_APCC_ABBAyCdc20_2
0.6389
p.G1289V
TCGA-91-A4BC
LUAD
TCGA
KARLHTE
LIG_APCC_ABBAyCdc20_2
0.2778
p.G1289V
DO45422
LUAD
ICGC
KARLHTE
LIG_APCC_ABBAyCdc20_2
0.2778
p.E1290D
TCGA-44-7662
LUAD
TCGA
KARLHTE
LIG_APCC_ABBAyCdc20_2
0.25
p.E1290D
DO23597
LUAD
ICGC
KARLHTE
LIG_APCC_ABBAyCdc20_2
0.25
p.R1272C
TCGA-D6-6516
HNSC
TCGA
KARLHTE
LIG_APCC_ABBAyCdc20_2
0.0833
p.R1272C
TCGA-FP-A4BE
STAD
TCGA
KARLHTE
LIG_APCC_ABBAyCdc20_2
0.0833
p.R1272C
DO15623
HNSC
ICGC
KARLHTE
LIG_APCC_ABBAyCdc20_2
0.0833
p.R1272C
DO48016
STAD
ICGC
KARLHTE
LIG_APCC_ABBAyCdc20_2
0.0833
p.D1296H
SIDM00590
Oral Cavity Carcinoma
GDSC
KARLHTE
LIG_APCC_ABBAyCdc20_2
0.0833
p.D1296H
SIDM00792
Small Cell Lung Carcinoma
GDSC
KARLHTE
LIG_APCC_ABBAyCdc20_2
0.0833
p.D1296H
ACH-000472
Head and Neck Cancer
CCLE
KARLHTE
LIG_APCC_ABBAyCdc20_2
0.0833
p.D1296H
ACH-002170
Lung Cancer
CCLE
KARLHTE
LIG_APCC_ABBAyCdc20_2
0.0833
p.D1296H
HSC-2
upper_aerodigestive_tract
COSMIC
KARLHTE
LIG_APCC_ABBAyCdc20_2
0.0833
p.D1296H
NCI-H1688
lung
COSMIC
KARLHTE
LIG_APCC_ABBAyCdc20_2
0.0833
p.E1297K
TCGA-EB-A6QZ
SKCM
TCGA
KARLHTE
LIG_APCC_ABBAyCdc20_2
0.0556
p.E1297K
TCGA-GF-A6C9
SKCM
TCGA
KARLHTE
LIG_APCC_ABBAyCdc20_2
0.0556
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Drug responses associated with MYH4 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of KARLHTE
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y623
Myosin-4
LIG_APCC_ABBAyCdc20_2
1281:1287
KARLHTE
APC,CDC20,FZR1
0.75
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