DegronMD

Uniprot ID: Q9Y623

Source protein: Myosin-4

Source gene: MYH4

Class: LIG_APCC_ABBAyCdc20_2

Location: 1281:1287

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.75

ASA_SCORE: 91.3286

COIL: 0.0319

CONS_SCORE: 0.3767

DSS_SCORE: 0.4747

HELIX: 0.969

FCONS_SCORE: 0.9876

RIG_SCORE: 0.6933

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1287K	TCGA-21-1079	LUSC	TCGA	KARLHTE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E1287K	TCGA-EB-A3XD	SKCM	TCGA	KARLHTE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E1287K	TCGA-EB-A44O	SKCM	TCGA	KARLHTE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E1287K	DO26846	LUSC	ICGC	KARLHTE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E1287K	DO37871	SKCM	ICGC	KARLHTE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E1287K	DO47272	SKCM	ICGC	KARLHTE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E1290D	TCGA-44-7662	LUAD	TCGA	KARLHTE	LIG_APCC_ABBAyCdc20_2	0.25
p.E1290D	DO23597	LUAD	ICGC	KARLHTE	LIG_APCC_ABBAyCdc20_2	0.25
p.G1289V	TCGA-91-A4BC	LUAD	TCGA	KARLHTE	LIG_APCC_ABBAyCdc20_2	0.2778
p.G1289V	DO45422	LUAD	ICGC	KARLHTE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R1272C	TCGA-D6-6516	HNSC	TCGA	KARLHTE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R1272C	TCGA-FP-A4BE	STAD	TCGA	KARLHTE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R1272C	DO15623	HNSC	ICGC	KARLHTE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R1272C	DO48016	STAD	ICGC	KARLHTE	LIG_APCC_ABBAyCdc20_2	0.0833
p.E1297K	TCGA-EB-A6QZ	SKCM	TCGA	KARLHTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E1297K	TCGA-GF-A6C9	SKCM	TCGA	KARLHTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E1297K	DO222708	MELA	ICGC	KARLHTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E1297K	DO222898	MELA	ICGC	KARLHTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E1297K	DO48626	SKCM	ICGC	KARLHTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E1297K	DO51254	SKCM	ICGC	KARLHTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.H1285R	DO228359	LICA	ICGC	KARLHTE	LIG_APCC_ABBAyCdc20_2	0.8244
p.T1286K	DO229041	LICA	ICGC	KARLHTE	LIG_APCC_ABBAyCdc20_2	0.7306
p.S1292L	DO218908	SKCA	ICGC	KARLHTE	LIG_APCC_ABBAyCdc20_2	0.6389
p.D1296H	SIDM00590	Oral Cavity Carcinoma	GDSC	KARLHTE	LIG_APCC_ABBAyCdc20_2	0.0833
p.D1296H	SIDM00792	Small Cell Lung Carcinoma	GDSC	KARLHTE	LIG_APCC_ABBAyCdc20_2	0.0833
p.D1296H	ACH-000472	Head and Neck Cancer	CCLE	KARLHTE	LIG_APCC_ABBAyCdc20_2	0.0833
p.D1296H	ACH-002170	Lung Cancer	CCLE	KARLHTE	LIG_APCC_ABBAyCdc20_2	0.0833
p.D1296H	HSC-2	upper_aerodigestive_tract	COSMIC	KARLHTE	LIG_APCC_ABBAyCdc20_2	0.0833
p.D1296H	NCI-H1688	lung	COSMIC	KARLHTE	LIG_APCC_ABBAyCdc20_2	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KARLHTE

Degron related mutations and impact score

Drug responses associated with MYH4 mutations

All proteins holding degron of KARLHTE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y623	Myosin-4	LIG_APCC_ABBAyCdc20_2	1281:1287	KARLHTE	APC,CDC20,FZR1	0.75	More...