DegronMD - Q9Y644(RFNG)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L312F	TCGA-BA-5556	HNSC	TCGA	FSLHQD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.0556
p.A294V	TCGA-BR-7707	STAD	TCGA	FSLHQD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.25
p.R305L	TCGA-FS-A1ZZ	SKCM	TCGA	FSLHQD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.25
p.G296S	TCGA-VQ-A8P2	STAD	TCGA	FSLHQD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.3056
p.G296S	DO51761	STAD	ICGC	FSLHQD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.3056
p.H288Q	DO230334	COCA	ICGC	FSLHQD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.0833
p.H288Q	DO229010	COCA	ICGC	FSLHQD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.0833
p.H288Q	DO229013	COCA	ICGC	FSLHQD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.0833
p.H288Q	DO229016	COCA	ICGC	FSLHQD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.0833
p.H288Q	DO229005	COCA	ICGC	FSLHQD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.0833
p.H288Q	DO228947	LICA	ICGC	FSLHQD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.0833
p.H288Q	DO230529	LUSC	ICGC	FSLHQD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.0833
p.H288Q	DO52365	LUSC	ICGC	FSLHQD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.0833
p.P303R	DO233273	GACA	ICGC	FSLHQD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.3056
p.H300Y	DO229218	THCA	ICGC	FSLHQD	LIG_APCC_ABBA_1	297:302	Mutation altering degron motif	0.6118
p.S298N	SIDM01016	T-Lymphoblastic Leukemia	GDSC	FSLHQD	LIG_APCC_ABBA_1	297:302	Mutation altering degron motif	0.5958
p.S298N	SIDM01263	T-Lymphoblastic Leukemia	GDSC	FSLHQD	LIG_APCC_ABBA_1	297:302	Mutation altering degron motif	0.5958
p.S298N	ACH-000995	Leukemia	CCLE	FSLHQD	LIG_APCC_ABBA_1	297:302	Mutation altering degron motif	0.5958
p.S298N	Jurkat	haematopoietic and lymphoid tissue	COSMIC	FSLHQD	LIG_APCC_ABBA_1	297:302	Mutation altering degron motif	0.5958
p.V293M	SIDM00807	Bladder Carcinoma	GDSC	FSLHQD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.2222
p.V293M	ACH-000905	Bladder Cancer	CCLE	FSLHQD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.2222
p.V293M	5637	urinary tract	COSMIC	FSLHQD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.2222
p.R305W	SIDM01525	Acute Myeloid Leukemia	GDSC	FSLHQD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.25

Kaplan plot for RFNG in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RFNG

UniProt ID: Q9Y644

Entrez ID: 5986

Protein name: Beta-1,3-N-acetylglucosaminyltransferase radical fringe (EC 2.4.1.222) (O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RFNG in