DegronMD

Uniprot ID: Q9Y644

Source protein: Beta-1,3-N-acetylglucosaminyltransferase radical fringe

Source gene: RFNG

Class: LIG_APCC_ABBA_1

Location: 297:302

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9605

ASA_SCORE: 62.3333

COIL: 0.7882

CONS_SCORE: 0.5598

DSS_SCORE: 0.3154

HELIX: 0.072

FCONS_SCORE: 0.8413

RIG_SCORE: 0.7376

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L312F	TCGA-BA-5556	HNSC	TCGA	FSLHQD	LIG_APCC_ABBA_1	0.0556
p.A294V	TCGA-BR-7707	STAD	TCGA	FSLHQD	LIG_APCC_ABBA_1	0.25
p.R305L	TCGA-FS-A1ZZ	SKCM	TCGA	FSLHQD	LIG_APCC_ABBA_1	0.25
p.G296S	TCGA-VQ-A8P2	STAD	TCGA	FSLHQD	LIG_APCC_ABBA_1	0.3056
p.G296S	DO51761	STAD	ICGC	FSLHQD	LIG_APCC_ABBA_1	0.3056
p.H288Q	DO230334	COCA	ICGC	FSLHQD	LIG_APCC_ABBA_1	0.0833
p.H288Q	DO229010	COCA	ICGC	FSLHQD	LIG_APCC_ABBA_1	0.0833
p.H288Q	DO229013	COCA	ICGC	FSLHQD	LIG_APCC_ABBA_1	0.0833
p.H288Q	DO229016	COCA	ICGC	FSLHQD	LIG_APCC_ABBA_1	0.0833
p.H288Q	DO229005	COCA	ICGC	FSLHQD	LIG_APCC_ABBA_1	0.0833
p.H288Q	DO228947	LICA	ICGC	FSLHQD	LIG_APCC_ABBA_1	0.0833
p.H288Q	DO230529	LUSC	ICGC	FSLHQD	LIG_APCC_ABBA_1	0.0833
p.H288Q	DO52365	LUSC	ICGC	FSLHQD	LIG_APCC_ABBA_1	0.0833
p.P303R	DO233273	GACA	ICGC	FSLHQD	LIG_APCC_ABBA_1	0.3056
p.H300Y	DO229218	THCA	ICGC	FSLHQD	LIG_APCC_ABBA_1	0.6118
p.S298N	SIDM01016	T-Lymphoblastic Leukemia	GDSC	FSLHQD	LIG_APCC_ABBA_1	0.5958
p.S298N	SIDM01263	T-Lymphoblastic Leukemia	GDSC	FSLHQD	LIG_APCC_ABBA_1	0.5958
p.S298N	ACH-000995	Leukemia	CCLE	FSLHQD	LIG_APCC_ABBA_1	0.5958
p.S298N	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	FSLHQD	LIG_APCC_ABBA_1	0.5958
p.V293M	SIDM00807	Bladder Carcinoma	GDSC	FSLHQD	LIG_APCC_ABBA_1	0.2222
p.V293M	ACH-000905	Bladder Cancer	CCLE	FSLHQD	LIG_APCC_ABBA_1	0.2222
p.V293M	5637	urinary_tract	COSMIC	FSLHQD	LIG_APCC_ABBA_1	0.2222
p.R305W	SIDM01525	Acute Myeloid Leukemia	GDSC	FSLHQD	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y644	Beta-1,3-N-acetylglucosaminyltransferase radical fringe	LIG_APCC_ABBA_1	297:302	FSLHQD	APC,CDC20,FZR1	0.9605	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons