DegronMD - Q9Y676(MRPS18B)

MRPS18B

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S42Y	TCGA-AP-A056	UCEC	TCGA	ISPYKD	LIG_APCC_ABBA_1	48:53	Mutation blocking phosphorylation signal	0.6111
p.S42Y	DO43971	UCEC	ICGC	ISPYKD	LIG_APCC_ABBA_1	48:53	Mutation blocking phosphorylation signal	0.6111
p.P50H	TCGA-AX-A2HD	UCEC	TCGA	ISPYKD	LIG_APCC_ABBA_1	48:53	Mutation altering degron motif	0.7694
p.P50H	DO42608	UCEC	ICGC	ISPYKD	LIG_APCC_ABBA_1	48:53	Mutation altering degron motif	0.7694
p.E60K	TCGA-FD-A6TC	BLCA	TCGA	ISPYKD	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1389
p.E60K	TCGA-GM-A3NW	BRCA	TCGA	ISPYKD	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1389
p.E60K	DO49755	BLCA	ICGC	ISPYKD	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1389
p.E60K	DO3001	BRCA	ICGC	ISPYKD	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1389
p.S44F	TCGA-FI-A2D5	UCEC	TCGA	ISPYKD	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.2222
p.S44F	DO41331	UCEC	ICGC	ISPYKD	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.2222
p.E39Q	DO223030	ESCA	ICGC	ISPYKD	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.0833
p.P55L	SIDM01782	Oral Cavity Carcinoma	GDSC	ISPYKD	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc