DegronMD

Uniprot ID: Q9Y676

Source protein: 28S ribosomal protein S18b, mitochondrial

Source gene: MRPS18B

Class: LIG_APCC_ABBA_1

Location: 48:53

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9917

ASA_SCORE: 79.95

COIL: 0.854

CONS_SCORE: 0.4351

DSS_SCORE: 0.3707

HELIX: 0.087

FCONS_SCORE: 0.9032

RIG_SCORE: 0.7111

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S42Y	TCGA-AP-A056	UCEC	TCGA	ISPYKD	LIG_APCC_ABBA_1	0.6111
p.S42Y	DO43971	UCEC	ICGC	ISPYKD	LIG_APCC_ABBA_1	0.6111
p.P50H	TCGA-AX-A2HD	UCEC	TCGA	ISPYKD	LIG_APCC_ABBA_1	0.7694
p.P50H	DO42608	UCEC	ICGC	ISPYKD	LIG_APCC_ABBA_1	0.7694
p.E60K	TCGA-FD-A6TC	BLCA	TCGA	ISPYKD	LIG_APCC_ABBA_1	0.1389
p.E60K	TCGA-GM-A3NW	BRCA	TCGA	ISPYKD	LIG_APCC_ABBA_1	0.1389
p.E60K	DO49755	BLCA	ICGC	ISPYKD	LIG_APCC_ABBA_1	0.1389
p.E60K	DO3001	BRCA	ICGC	ISPYKD	LIG_APCC_ABBA_1	0.1389
p.S44F	TCGA-FI-A2D5	UCEC	TCGA	ISPYKD	LIG_APCC_ABBA_1	0.2222
p.S44F	DO41331	UCEC	ICGC	ISPYKD	LIG_APCC_ABBA_1	0.2222
p.E39Q	DO223030	ESCA	ICGC	ISPYKD	LIG_APCC_ABBA_1	0.0833
p.P55L	SIDM01782	Oral Cavity Carcinoma	GDSC	ISPYKD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y676	28S ribosomal protein S18b, mitochondrial	LIG_APCC_ABBA_1	48:53	ISPYKD	APC,CDC20,FZR1	0.9917	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons