DegronMD - Q9Y679(AUP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K359N	TCGA-55-7227	LUAD	TCGA	PVTPQPT	DEG_SCF_FBW7_1	365:371	Mutation blocking ubiquitination signal	0.6111
p.K359N	DO24050	LUAD	ICGC	PVTPQPT	DEG_SCF_FBW7_1	365:371	Mutation blocking ubiquitination signal	0.6111
p.P365L	TCGA-B5-A11E	UCEC	TCGA	PVTPQPT	DEG_SCF_FBW7_1	365:371	Mutation altering degron motif	0.6471
p.P365L	DO41644	UCEC	ICGC	PVTPQPT	DEG_SCF_FBW7_1	365:371	Mutation altering degron motif	0.6471
p.P365L	SIDM01592	Breast Carcinoma	GDSC	PVTPQPT	DEG_SCF_FBW7_1	365:371	Mutation altering degron motif	0.6471
p.A372T	TCGA-BS-A0UV	UCEC	TCGA	PVTPQPT	DEG_SCF_FBW7_1	365:371	Mutation rewiring degron network	0.3056
p.A372T	DO42793	UCEC	ICGC	PVTPQPT	DEG_SCF_FBW7_1	365:371	Mutation rewiring degron network	0.3056
p.K377E	TCGA-DD-A4NI	LIHC	TCGA	PVTPQPT	DEG_SCF_FBW7_1	365:371	Mutation blocking ubiquitination signal	0.6111
p.K377E	DO45025	LIHC	ICGC	PVTPQPT	DEG_SCF_FBW7_1	365:371	Mutation blocking ubiquitination signal	0.6111
p.T374P	DO222637	BTCA	ICGC	PVTPQPT	DEG_SCF_FBW7_1	365:371	Mutation rewiring degron network	0.25
p.W380R	DO233145	GACA	ICGC	PVTPQPT	DEG_SCF_FBW7_1	365:371	Mutation rewiring degron network	0.0833
p.S363A	DO233201	GACA	ICGC	PVTPQPT	DEG_SCF_FBW7_1	365:371	Mutation blocking phosphorylation signal	0.7222
p.S358T	DO228206	LICA	ICGC	PVTPQPT	DEG_SCF_FBW7_1	365:371	Mutation blocking phosphorylation signal	0.5833
p.A381V	DO50970	LICA	ICGC	PVTPQPT	DEG_SCF_FBW7_1	365:371	Mutation rewiring degron network	0.0556
p.P361S	DO222887	MELA	ICGC	PVTPQPT	DEG_SCF_FBW7_1	365:371	Mutation rewiring degron network	0.2222
p.A357D	DO27895	ORCA	ICGC	PVTPQPT	DEG_SCF_FBW7_1	365:371	Mutation rewiring degron network	0.1111

Kaplan plot for AUP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AUP1

UniProt ID: Q9Y679

Entrez ID: 550

Protein name: Lipid droplet-regulating VLDL assembly factor AUP1 (Ancient ubiquitous protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AUP1 in