DegronMD

Uniprot ID: Q9Y679

Source protein: Lipid droplet-regulating VLDL assembly factor AUP1

Source gene: AUP1

Class: DEG_SCF_FBW7_1

Location: 365:371

E3 ligase: FBXW7

DEGRON score: 0.9427

ASA_SCORE: 92.1

COIL: 0.8969

CONS_SCORE: 0.5285

DSS_SCORE: 0.5192

HELIX: 0.0813

FCONS_SCORE: 1.1166

RIG_SCORE: 0.6452

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K359N	TCGA-55-7227	LUAD	TCGA	PVTPQPT	DEG_SCF_FBW7_1	0.6111
p.K359N	DO24050	LUAD	ICGC	PVTPQPT	DEG_SCF_FBW7_1	0.6111
p.P365L	TCGA-B5-A11E	UCEC	TCGA	PVTPQPT	DEG_SCF_FBW7_1	0.6471
p.P365L	DO41644	UCEC	ICGC	PVTPQPT	DEG_SCF_FBW7_1	0.6471
p.P365L	SIDM01592	Breast Carcinoma	GDSC	PVTPQPT	DEG_SCF_FBW7_1	0.6471
p.A372T	TCGA-BS-A0UV	UCEC	TCGA	PVTPQPT	DEG_SCF_FBW7_1	0.3056
p.A372T	DO42793	UCEC	ICGC	PVTPQPT	DEG_SCF_FBW7_1	0.3056
p.K377E	TCGA-DD-A4NI	LIHC	TCGA	PVTPQPT	DEG_SCF_FBW7_1	0.6111
p.K377E	DO45025	LIHC	ICGC	PVTPQPT	DEG_SCF_FBW7_1	0.6111
p.T374P	DO222637	BTCA	ICGC	PVTPQPT	DEG_SCF_FBW7_1	0.25
p.W380R	DO233145	GACA	ICGC	PVTPQPT	DEG_SCF_FBW7_1	0.0833
p.S363A	DO233201	GACA	ICGC	PVTPQPT	DEG_SCF_FBW7_1	0.7222
p.S358T	DO228206	LICA	ICGC	PVTPQPT	DEG_SCF_FBW7_1	0.5833
p.A381V	DO50970	LICA	ICGC	PVTPQPT	DEG_SCF_FBW7_1	0.0556
p.P361S	DO222887	MELA	ICGC	PVTPQPT	DEG_SCF_FBW7_1	0.2222
p.A357D	DO27895	ORCA	ICGC	PVTPQPT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y679	Lipid droplet-regulating VLDL assembly factor AUP1	DEG_SCF_FBW7_1	365:371	PVTPQPT	FBXW7	0.9427	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons