DegronMD - Q9Y6D9(MAD1L1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R576C	TCGA-A6-5665	COAD	TCGA	LRGLLRAME	DEG_APCC_DBOX_1	571:579	Mutation altering degron motif	0.719
p.R576C	TCGA-D1-A17D	UCEC	TCGA	LRGLLRAME	DEG_APCC_DBOX_1	571:579	Mutation altering degron motif	0.719
p.R576C	SIDM00988	Kidney Carcinoma	GDSC	LRGLLRAME	DEG_APCC_DBOX_1	571:579	Mutation altering degron motif	0.719
p.R576H	TCGA-FI-A2D5	UCEC	TCGA	LRGLLRAME	DEG_APCC_DBOX_1	571:579	Mutation altering degron motif	0.7133
p.R576H	SIDM01951	Colorectal Carcinoma	GDSC	LRGLLRAME	DEG_APCC_DBOX_1	571:579	Mutation altering degron motif	0.7133
p.R576H	SIDM00311	Mesothelioma	GDSC	LRGLLRAME	DEG_APCC_DBOX_1	571:579	Mutation altering degron motif	0.7133
p.R570L	TCGA-OR-A5KB	ACC	TCGA	LRGLLRAME	DEG_APCC_DBOX_1	571:579	Mutation rewiring degron network	0.3056
p.R572C	TCGA-WS-AB45	COAD	TCGA	LRGLLRAME	DEG_APCC_DBOX_1	571:579	Mutation altering degron motif	0.8301
p.S579L	DO223588	BLCA	ICGC	LRGLLRAME	DEG_APCC_DBOX_1	571:579	Mutation altering degron motif	0.7667
p.S579L	DO10132	COAD	ICGC	LRGLLRAME	DEG_APCC_DBOX_1	571:579	Mutation altering degron motif	0.7667
p.S579L	DO7882	COAD	ICGC	LRGLLRAME	DEG_APCC_DBOX_1	571:579	Mutation altering degron motif	0.7667
p.S579L	DO42033	UCEC	ICGC	LRGLLRAME	DEG_APCC_DBOX_1	571:579	Mutation altering degron motif	0.7667
p.D569N	DO14250	HNSC	ICGC	LRGLLRAME	DEG_APCC_DBOX_1	571:579	Mutation rewiring degron network	0.2778
p.D569N	NCI-SNU-1	stomach	COSMIC	LRGLLRAME	DEG_APCC_DBOX_1	571:579	Mutation rewiring degron network	0.2778
p.T576S	DO220855	MELA	ICGC	LRGLLRAME	DEG_APCC_DBOX_1	571:579	Mutation altering degron motif	0.7116
p.A564V	DO51407	PRAD	ICGC	LRGLLRAME	DEG_APCC_DBOX_1	571:579	Mutation rewiring degron network	0.1389
p.D569G	DO47877	STAD	ICGC	LRGLLRAME	DEG_APCC_DBOX_1	571:579	Mutation rewiring degron network	0.2778
p.G568V	DO38214	STAD	ICGC	LRGLLRAME	DEG_APCC_DBOX_1	571:579	Mutation rewiring degron network	0.25
p.S581Y	DO229211	THCA	ICGC	LRGLLRAME	DEG_APCC_DBOX_1	571:579	Mutation rewiring degron network	0.2778
p.S577I	DO42472	UCEC	ICGC	LRGLLRAME	DEG_APCC_DBOX_1	571:579	Mutation altering degron motif	0.7341
p.E569K	SIDM01034	B-Lymphoblastic Leukemia	GDSC	LRGLLRAME	DEG_APCC_DBOX_1	571:579	Mutation rewiring degron network	0.2778
p.E569K	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	LRGLLRAME	DEG_APCC_DBOX_1	571:579	Mutation rewiring degron network	0.2778
p.A577T	ACH-000955	Colon/Colorectal Cancer	CCLE	LRGLLRAME	DEG_APCC_DBOX_1	571:579	Mutation altering degron motif	0.6028
p.E565K	ACH-001610	Brain Cancer	CCLE	LRGLLRAME	DEG_APCC_DBOX_1	571:579	Mutation rewiring degron network	0.1667

Kaplan plot for MAD1L1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAD1L1

UniProt ID: Q9Y6D9

Entrez ID: 8379

Protein name: Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAD1L1 in