DegronMD

Uniprot ID: Q9Y6D9

Source protein: Mitotic spindle assembly checkpoint protein MAD1

Source gene: MAD1L1

Class: DEG_APCC_DBOX_1

Location: 571:579

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9585

ASA_SCORE: 75.6

COIL: 0.0464

CONS_SCORE: 0.4055

DSS_SCORE: 0.4013

HELIX: 0.954

FCONS_SCORE: 1.2002

RIG_SCORE: 0.7587

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R576C	TCGA-A6-5665	COAD	TCGA	LRGLLRAME	DEG_APCC_DBOX_1	0.719
p.R576C	TCGA-D1-A17D	UCEC	TCGA	LRGLLRAME	DEG_APCC_DBOX_1	0.719
p.R576C	SIDM00988	Kidney Carcinoma	GDSC	LRGLLRAME	DEG_APCC_DBOX_1	0.719
p.R576H	TCGA-FI-A2D5	UCEC	TCGA	LRGLLRAME	DEG_APCC_DBOX_1	0.7133
p.R576H	SIDM01951	Colorectal Carcinoma	GDSC	LRGLLRAME	DEG_APCC_DBOX_1	0.7133
p.R576H	SIDM00311	Mesothelioma	GDSC	LRGLLRAME	DEG_APCC_DBOX_1	0.7133
p.R570L	TCGA-OR-A5KB	ACC	TCGA	LRGLLRAME	DEG_APCC_DBOX_1	0.3056
p.R572C	TCGA-WS-AB45	COAD	TCGA	LRGLLRAME	DEG_APCC_DBOX_1	0.8301
p.S579L	DO223588	BLCA	ICGC	LRGLLRAME	DEG_APCC_DBOX_1	0.7667
p.S579L	DO10132	COAD	ICGC	LRGLLRAME	DEG_APCC_DBOX_1	0.7667
p.S579L	DO7882	COAD	ICGC	LRGLLRAME	DEG_APCC_DBOX_1	0.7667
p.S579L	DO42033	UCEC	ICGC	LRGLLRAME	DEG_APCC_DBOX_1	0.7667
p.D569N	DO14250	HNSC	ICGC	LRGLLRAME	DEG_APCC_DBOX_1	0.2778
p.D569N	NCI-SNU-1	stomach	COSMIC	LRGLLRAME	DEG_APCC_DBOX_1	0.2778
p.T576S	DO220855	MELA	ICGC	LRGLLRAME	DEG_APCC_DBOX_1	0.7116
p.A564V	DO51407	PRAD	ICGC	LRGLLRAME	DEG_APCC_DBOX_1	0.1389
p.D569G	DO47877	STAD	ICGC	LRGLLRAME	DEG_APCC_DBOX_1	0.2778
p.G568V	DO38214	STAD	ICGC	LRGLLRAME	DEG_APCC_DBOX_1	0.25
p.S581Y	DO229211	THCA	ICGC	LRGLLRAME	DEG_APCC_DBOX_1	0.2778
p.S577I	DO42472	UCEC	ICGC	LRGLLRAME	DEG_APCC_DBOX_1	0.7341
p.E569K	SIDM01034	B-Lymphoblastic Leukemia	GDSC	LRGLLRAME	DEG_APCC_DBOX_1	0.2778
p.E569K	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	LRGLLRAME	DEG_APCC_DBOX_1	0.2778
p.A577T	ACH-000955	Colon/Colorectal Cancer	CCLE	LRGLLRAME	DEG_APCC_DBOX_1	0.6028
p.E565K	ACH-001610	Brain Cancer	CCLE	LRGLLRAME	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6D9	Mitotic spindle assembly checkpoint protein MAD1	DEG_APCC_DBOX_1	571:579	LRGLLRAME	APC,CDC20,FZR1	0.9585	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons