DegronMD - Q9Y6K8(AK5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R76Q	TCGA-17-Z060	LUAD	TCGA	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation altering degron motif	0.6218
p.R76Q	TCGA-AG-3885	READ	TCGA	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation altering degron motif	0.6218
p.R76Q	TCGA-CG-5723	STAD	TCGA	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation altering degron motif	0.6218
p.P91L	TCGA-3N-A9WC	SKCM	TCGA	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation rewiring degron network	0.1389
p.L70I	TCGA-85-8666	LUSC	TCGA	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation rewiring degron network	0.1667
p.R94W	TCGA-A5-A1OF	UCEC	TCGA	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation rewiring degron network	0.0556
p.R94W	ACH-000937	Leukemia	CCLE	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation rewiring degron network	0.0556
p.R93W	TCGA-AG-A002	READ	TCGA	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation rewiring degron network	0.0833
p.P69Q	TCGA-CN-A63U	HNSC	TCGA	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation rewiring degron network	0.1389
p.P68H	TCGA-D3-A2JC	SKCM	TCGA	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation rewiring degron network	0.1111
p.R76W	TCGA-D6-A6EQ	HNSC	TCGA	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation altering degron motif	0.7523
p.R76W	DO225337	BRCA	ICGC	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation altering degron motif	0.7523
p.R76W	DO52085	HNSC	ICGC	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation altering degron motif	0.7523
p.N82K	TCGA-DK-A6AW	BLCA	TCGA	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation altering degron motif	0.5806
p.P91Q	TCGA-ER-A2NH	SKCM	TCGA	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation rewiring degron network	0.1389
p.R94Q	TCGA-KL-8335	KICH	TCGA	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation rewiring degron network	0.0556
p.R68W	DO222798	COCA	ICGC	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation rewiring degron network	0.1111
p.R68W	DO42568	UCEC	ICGC	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation rewiring degron network	0.1111
p.H76N	DO222884	COCA	ICGC	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation altering degron motif	0.7423
p.E94K	DO10842	ESAD	ICGC	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation rewiring degron network	0.0556
p.P74T	DO222539	ESCA	ICGC	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation rewiring degron network	0.2778
p.R68Q	DO220343	KICH	ICGC	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation rewiring degron network	0.1111
p.D83G	DO22237	LGG	ICGC	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation altering degron motif	0.7198
p.Q77E	DO26526	LUSC	ICGC	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation altering degron motif	0.6744
p.R71G	DO50099	LUSC	ICGC	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation rewiring degron network	0.1944
p.R67W	DO222837	MELA	ICGC	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation rewiring degron network	0.0833
p.R71Q	DO47767	STAD	ICGC	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation rewiring degron network	0.1944
p.F78L	DO41644	UCEC	ICGC	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation altering degron motif	0.6981
p.I93M	DO41379	UCEC	ICGC	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation rewiring degron network	0.0833
p.F90I	SIDM01304	Colorectal Carcinoma	GDSC	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation rewiring degron network	0.1667
p.F77L	ACH-000531	Non-Cancerous	CCLE	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation altering degron motif	0.6981
p.R71W	PCI-15A	upper aerodigestive tract	COSMIC	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation rewiring degron network	0.1944
p.I80M	AN3-CA	endometrium	COSMIC	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation altering degron motif	0.7618
p.A90V	AN3-CA	endometrium	COSMIC	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation rewiring degron network	0.1667
p.S79F	Mewo	skin	COSMIC	RRSFLRNVM	DEG_APCC_DBOX_1	76:84	Mutation altering degron motif	0.7982

Kaplan plot for AK5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AK5

UniProt ID: Q9Y6K8

Entrez ID: 26289

Protein name: Adenylate kinase isoenzyme 5 (AK 5) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AK5 in