DegronMD

Uniprot ID: Q9Y6K8

Source protein: Adenylate kinase isoenzyme 5

Source gene: AK5

Class: DEG_APCC_DBOX_1

Location: 76:84

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9623

ASA_SCORE: 103.7667

COIL: 0.6359

CONS_SCORE: 0.3511

DSS_SCORE: 0.4994

HELIX: 0.3217

FCONS_SCORE: 1.1376

RIG_SCORE: 0.7382

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R76Q	TCGA-17-Z060	LUAD	TCGA	RRSFLRNVM	DEG_APCC_DBOX_1	0.6218
p.R76Q	TCGA-AG-3885	READ	TCGA	RRSFLRNVM	DEG_APCC_DBOX_1	0.6218
p.R76Q	TCGA-CG-5723	STAD	TCGA	RRSFLRNVM	DEG_APCC_DBOX_1	0.6218
p.P91L	TCGA-3N-A9WC	SKCM	TCGA	RRSFLRNVM	DEG_APCC_DBOX_1	0.1389
p.L70I	TCGA-85-8666	LUSC	TCGA	RRSFLRNVM	DEG_APCC_DBOX_1	0.1667
p.R94W	TCGA-A5-A1OF	UCEC	TCGA	RRSFLRNVM	DEG_APCC_DBOX_1	0.0556
p.R94W	ACH-000937	Leukemia	CCLE	RRSFLRNVM	DEG_APCC_DBOX_1	0.0556
p.R93W	TCGA-AG-A002	READ	TCGA	RRSFLRNVM	DEG_APCC_DBOX_1	0.0833
p.P69Q	TCGA-CN-A63U	HNSC	TCGA	RRSFLRNVM	DEG_APCC_DBOX_1	0.1389
p.P68H	TCGA-D3-A2JC	SKCM	TCGA	RRSFLRNVM	DEG_APCC_DBOX_1	0.1111
p.R76W	TCGA-D6-A6EQ	HNSC	TCGA	RRSFLRNVM	DEG_APCC_DBOX_1	0.7523
p.R76W	DO225337	BRCA	ICGC	RRSFLRNVM	DEG_APCC_DBOX_1	0.7523
p.R76W	DO52085	HNSC	ICGC	RRSFLRNVM	DEG_APCC_DBOX_1	0.7523
p.N82K	TCGA-DK-A6AW	BLCA	TCGA	RRSFLRNVM	DEG_APCC_DBOX_1	0.5806
p.P91Q	TCGA-ER-A2NH	SKCM	TCGA	RRSFLRNVM	DEG_APCC_DBOX_1	0.1389
p.R94Q	TCGA-KL-8335	KICH	TCGA	RRSFLRNVM	DEG_APCC_DBOX_1	0.0556
p.R68W	DO222798	COCA	ICGC	RRSFLRNVM	DEG_APCC_DBOX_1	0.1111
p.R68W	DO42568	UCEC	ICGC	RRSFLRNVM	DEG_APCC_DBOX_1	0.1111
p.H76N	DO222884	COCA	ICGC	RRSFLRNVM	DEG_APCC_DBOX_1	0.7423
p.E94K	DO10842	ESAD	ICGC	RRSFLRNVM	DEG_APCC_DBOX_1	0.0556
p.P74T	DO222539	ESCA	ICGC	RRSFLRNVM	DEG_APCC_DBOX_1	0.2778
p.R68Q	DO220343	KICH	ICGC	RRSFLRNVM	DEG_APCC_DBOX_1	0.1111
p.D83G	DO22237	LGG	ICGC	RRSFLRNVM	DEG_APCC_DBOX_1	0.7198
p.Q77E	DO26526	LUSC	ICGC	RRSFLRNVM	DEG_APCC_DBOX_1	0.6744
p.R71G	DO50099	LUSC	ICGC	RRSFLRNVM	DEG_APCC_DBOX_1	0.1944
p.R67W	DO222837	MELA	ICGC	RRSFLRNVM	DEG_APCC_DBOX_1	0.0833
p.R71Q	DO47767	STAD	ICGC	RRSFLRNVM	DEG_APCC_DBOX_1	0.1944
p.F78L	DO41644	UCEC	ICGC	RRSFLRNVM	DEG_APCC_DBOX_1	0.6981
p.I93M	DO41379	UCEC	ICGC	RRSFLRNVM	DEG_APCC_DBOX_1	0.0833
p.F90I	SIDM01304	Colorectal Carcinoma	GDSC	RRSFLRNVM	DEG_APCC_DBOX_1	0.1667
p.F77L	ACH-000531	Non-Cancerous	CCLE	RRSFLRNVM	DEG_APCC_DBOX_1	0.6981
p.R71W	PCI-15A	upper_aerodigestive_tract	COSMIC	RRSFLRNVM	DEG_APCC_DBOX_1	0.1944
p.I80M	AN3-CA	endometrium	COSMIC	RRSFLRNVM	DEG_APCC_DBOX_1	0.7618
p.A90V	AN3-CA	endometrium	COSMIC	RRSFLRNVM	DEG_APCC_DBOX_1	0.1667
p.S79F	Mewo	skin	COSMIC	RRSFLRNVM	DEG_APCC_DBOX_1	0.7982

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRSFLRNVM

Degron related mutations and impact score

Drug responses associated with AK5 mutations

All proteins holding degron of RRSFLRNVM

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6K8	Adenylate kinase isoenzyme 5	DEG_APCC_DBOX_1	76:84	RRSFLRNVM	APC,CDC20,FZR1	0.9623	More...