DegronMD - Q9Y6Q3(ZFP37)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H283Y	TCGA-90-7769	LUSC	TCGA	KPQACVKPY	DEG_SIAH_1	285:293	Mutation rewiring degron network	0.2778
p.H283Y	DO26822	LUSC	ICGC	KPQACVKPY	DEG_SIAH_1	285:293	Mutation rewiring degron network	0.2778
p.P286H	TCGA-A5-A0G2	UCEC	TCGA	KPQACVKPY	DEG_SIAH_1	285:293	Mutation altering degron motif	0.7694
p.P286H	DO41235	UCEC	ICGC	KPQACVKPY	DEG_SIAH_1	285:293	Mutation altering degron motif	0.7694
p.Q297E	TCGA-C8-A275	BRCA	TCGA	KPQACVKPY	DEG_SIAH_1	285:293	Mutation rewiring degron network	0.2222
p.Q297E	DO2359	BRCA	ICGC	KPQACVKPY	DEG_SIAH_1	285:293	Mutation rewiring degron network	0.2222
p.P275H	TCGA-EE-A2MM	SKCM	TCGA	KPQACVKPY	DEG_SIAH_1	285:293	Mutation rewiring degron network	0.0556
p.P275H	DO37770	SKCM	ICGC	KPQACVKPY	DEG_SIAH_1	285:293	Mutation rewiring degron network	0.0556
p.P286S	TCGA-EO-A22U	UCEC	TCGA	KPQACVKPY	DEG_SIAH_1	285:293	Mutation altering degron motif	0.6752
p.P286S	DO43755	UCEC	ICGC	KPQACVKPY	DEG_SIAH_1	285:293	Mutation altering degron motif	0.6752
p.A288S	TCGA-KL-8335	KICH	TCGA	KPQACVKPY	DEG_SIAH_1	285:293	Mutation altering degron motif	0.7588
p.A288S	DO220343	KICH	ICGC	KPQACVKPY	DEG_SIAH_1	285:293	Mutation altering degron motif	0.7588
p.P292T	DO225118	BRCA	ICGC	KPQACVKPY	DEG_SIAH_1	285:293	Mutation altering degron motif	0.7031
p.P292T	DO227860	BRCA	ICGC	KPQACVKPY	DEG_SIAH_1	285:293	Mutation altering degron motif	0.7031
p.P275T	DO228389	EOPC	ICGC	KPQACVKPY	DEG_SIAH_1	285:293	Mutation rewiring degron network	0.0556
p.S279L	DO229502	SKCA	ICGC	KPQACVKPY	DEG_SIAH_1	285:293	Mutation rewiring degron network	0.1667
p.K279N	SIDM01611	Endometrial Carcinoma	GDSC	KPQACVKPY	DEG_SIAH_1	285:293	Mutation rewiring degron network	0.1667
p.K279N	ACH-000996	Endometrial/Uterine Cancer	CCLE	KPQACVKPY	DEG_SIAH_1	285:293	Mutation rewiring degron network	0.1667
p.V301A	SUP-B15	haematopoietic and lymphoid tissue	COSMIC	KPQACVKPY	DEG_SIAH_1	285:293	Mutation rewiring degron network	0.1111
p.P293H	CHL-1	skin	COSMIC	KPQACVKPY	DEG_SIAH_1	285:293	Mutation altering degron motif	0.7694
p.V302A	SUP-B15	haematopoietic and lymphoid tissue	COSMIC	KPQACVKPY	DEG_SIAH_1	285:293	Mutation rewiring degron network	0.0833
p.P292H	CHL-1	skin	COSMIC	KPQACVKPY	DEG_SIAH_1	285:293	Mutation altering degron motif	0.7694

Kaplan plot for ZFP37 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZFP37

UniProt ID: Q9Y6Q3

Entrez ID: 7539

Protein name: Zinc finger protein 37 homolog (Zfp-37)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZFP37 in