DegronMD

Uniprot ID: Q9Y6Q3

Source protein: Zinc finger protein 37 homolog

Source gene: ZFP37

Class: DEG_SIAH_1

Location: 285:293

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9931

ASA_SCORE: 75.3444

COIL: 0.7599

CONS_SCORE: 0.662

DSS_SCORE: 0.3199

HELIX: 0.0333

FCONS_SCORE: 0.8592

RIG_SCORE: 0.7286

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H283Y	TCGA-90-7769	LUSC	TCGA	KPQACVKPY	DEG_SIAH_1	0.2778
p.H283Y	DO26822	LUSC	ICGC	KPQACVKPY	DEG_SIAH_1	0.2778
p.P286H	TCGA-A5-A0G2	UCEC	TCGA	KPQACVKPY	DEG_SIAH_1	0.7694
p.P286H	DO41235	UCEC	ICGC	KPQACVKPY	DEG_SIAH_1	0.7694
p.Q297E	TCGA-C8-A275	BRCA	TCGA	KPQACVKPY	DEG_SIAH_1	0.2222
p.Q297E	DO2359	BRCA	ICGC	KPQACVKPY	DEG_SIAH_1	0.2222
p.P275H	TCGA-EE-A2MM	SKCM	TCGA	KPQACVKPY	DEG_SIAH_1	0.0556
p.P275H	DO37770	SKCM	ICGC	KPQACVKPY	DEG_SIAH_1	0.0556
p.P286S	TCGA-EO-A22U	UCEC	TCGA	KPQACVKPY	DEG_SIAH_1	0.6752
p.P286S	DO43755	UCEC	ICGC	KPQACVKPY	DEG_SIAH_1	0.6752
p.A288S	TCGA-KL-8335	KICH	TCGA	KPQACVKPY	DEG_SIAH_1	0.7588
p.A288S	DO220343	KICH	ICGC	KPQACVKPY	DEG_SIAH_1	0.7588
p.P292T	DO225118	BRCA	ICGC	KPQACVKPY	DEG_SIAH_1	0.7031
p.P292T	DO227860	BRCA	ICGC	KPQACVKPY	DEG_SIAH_1	0.7031
p.P275T	DO228389	EOPC	ICGC	KPQACVKPY	DEG_SIAH_1	0.0556
p.S279L	DO229502	SKCA	ICGC	KPQACVKPY	DEG_SIAH_1	0.1667
p.K279N	SIDM01611	Endometrial Carcinoma	GDSC	KPQACVKPY	DEG_SIAH_1	0.1667
p.K279N	ACH-000996	Endometrial/Uterine Cancer	CCLE	KPQACVKPY	DEG_SIAH_1	0.1667
p.V301A	SUP-B15	haematopoietic_and_lymphoid_tissue	COSMIC	KPQACVKPY	DEG_SIAH_1	0.1111
p.P293H	CHL-1	skin	COSMIC	KPQACVKPY	DEG_SIAH_1	0.7694
p.V302A	SUP-B15	haematopoietic_and_lymphoid_tissue	COSMIC	KPQACVKPY	DEG_SIAH_1	0.0833
p.P292H	CHL-1	skin	COSMIC	KPQACVKPY	DEG_SIAH_1	0.7694

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6Q3	Zinc finger protein 37 homolog	DEG_SIAH_1	285:293	KPQACVKPY	SIAH1,SIAH2,SIAH3	0.9931	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons