DegronMD - Q9Y6R7(FCGBP)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1407L	TCGA-49-6743	LUAD	TCGA	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation rewiring degron network	0.1111
p.S1407L	DO26092	LUAD	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation rewiring degron network	0.1111
p.S1426Y	TCGA-55-8092	LUAD	TCGA	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation rewiring degron network	0.25
p.S1426Y	DO26220	LUAD	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation rewiring degron network	0.25
p.S1426F	TCGA-95-A4VN	LUAD	TCGA	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation rewiring degron network	0.25
p.S1426F	DO51199	LUAD	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation rewiring degron network	0.25
p.G1416D	TCGA-CV-7437	HNSC	TCGA	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation altering degron motif	0.6087
p.G1416D	DO14902	HNSC	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation altering degron motif	0.6087
p.P1430L	TCGA-D1-A177	UCEC	TCGA	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation rewiring degron network	0.1389
p.P1430L	DO42528	UCEC	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation rewiring degron network	0.1389
p.P1430L	SIDM00056	Thyroid Gland Carcinoma	GDSC	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation rewiring degron network	0.1389
p.P1427S	TCGA-D9-A1JW	SKCM	TCGA	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation rewiring degron network	0.2222
p.P1427S	TCGA-FR-A3YN	SKCM	TCGA	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation rewiring degron network	0.2222
p.P1427S	DO229465	SKCA	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation rewiring degron network	0.2222
p.P1427S	DO37786	SKCM	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation rewiring degron network	0.2222
p.P1427S	DO38111	SKCM	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation rewiring degron network	0.2222
p.F1415L	TCGA-DI-A1BU	UCEC	TCGA	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation altering degron motif	0.6981
p.F1415L	DO229234	THCA	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation altering degron motif	0.6981
p.F1415L	DO42023	UCEC	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation altering degron motif	0.6981
p.D1425V	TCGA-GN-A267	SKCM	TCGA	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation rewiring degron network	0.2778
p.D1425V	DO38147	SKCM	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation rewiring degron network	0.2778
p.D1425N	TCGA-GN-A267	SKCM	TCGA	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation rewiring degron network	0.2778
p.D1425N	DO222536	MELA	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation rewiring degron network	0.2778
p.D1425N	DO38147	SKCM	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation rewiring degron network	0.2778
p.E1421K	TCGA-GN-A267	SKCM	TCGA	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation altering degron motif	0.591
p.E1421K	DO38147	SKCM	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation altering degron motif	0.591
p.P1431L	DO222875	MELA	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation rewiring degron network	0.1111
p.T1432I	DO219879	SKCA	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation rewiring degron network	0.0833
p.P1427L	DO229456	SKCA	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation rewiring degron network	0.2222
p.Q1408R	DO229221	THCA	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation rewiring degron network	0.1389
p.A1412T	ACH-000958	Colon/Colorectal Cancer	CCLE	FGNSWEEVV	DEG_MDM2_SWIB_1	1415:1423	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FCGBP

UniProt ID: Q9Y6R7

Entrez ID: 8857

Protein name: IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for FCGBP in