DegronMD

Uniprot ID: Q9Y6R7

Source protein: IgGFc-binding protein

Source gene: FCGBP

Class: DEG_MDM2_SWIB_1

Location: 1415:1423

E3 ligase: MDM2

DEGRON score: 0.8448

ASA_SCORE: 45.3667

COIL: 0.3581

CONS_SCORE: 0.6549

DSS_SCORE: 0.5625

HELIX: 0.3976

FCONS_SCORE: 1.2838

RIG_SCORE: 0.6896

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1407L	TCGA-49-6743	LUAD	TCGA	FGNSWEEVV	DEG_MDM2_SWIB_1	0.1111
p.S1407L	DO26092	LUAD	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	0.1111
p.S1426Y	TCGA-55-8092	LUAD	TCGA	FGNSWEEVV	DEG_MDM2_SWIB_1	0.25
p.S1426Y	DO26220	LUAD	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	0.25
p.S1426F	TCGA-95-A4VN	LUAD	TCGA	FGNSWEEVV	DEG_MDM2_SWIB_1	0.25
p.S1426F	DO51199	LUAD	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	0.25
p.G1416D	TCGA-CV-7437	HNSC	TCGA	FGNSWEEVV	DEG_MDM2_SWIB_1	0.6087
p.G1416D	DO14902	HNSC	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	0.6087
p.P1430L	TCGA-D1-A177	UCEC	TCGA	FGNSWEEVV	DEG_MDM2_SWIB_1	0.1389
p.P1430L	DO42528	UCEC	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	0.1389
p.P1430L	SIDM00056	Thyroid Gland Carcinoma	GDSC	FGNSWEEVV	DEG_MDM2_SWIB_1	0.1389
p.P1427S	TCGA-D9-A1JW	SKCM	TCGA	FGNSWEEVV	DEG_MDM2_SWIB_1	0.2222
p.P1427S	TCGA-FR-A3YN	SKCM	TCGA	FGNSWEEVV	DEG_MDM2_SWIB_1	0.2222
p.P1427S	DO229465	SKCA	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	0.2222
p.P1427S	DO37786	SKCM	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	0.2222
p.P1427S	DO38111	SKCM	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	0.2222
p.F1415L	TCGA-DI-A1BU	UCEC	TCGA	FGNSWEEVV	DEG_MDM2_SWIB_1	0.6981
p.F1415L	DO229234	THCA	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	0.6981
p.F1415L	DO42023	UCEC	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	0.6981
p.D1425V	TCGA-GN-A267	SKCM	TCGA	FGNSWEEVV	DEG_MDM2_SWIB_1	0.2778
p.D1425V	DO38147	SKCM	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	0.2778
p.D1425N	TCGA-GN-A267	SKCM	TCGA	FGNSWEEVV	DEG_MDM2_SWIB_1	0.2778
p.D1425N	DO222536	MELA	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	0.2778
p.D1425N	DO38147	SKCM	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	0.2778
p.E1421K	TCGA-GN-A267	SKCM	TCGA	FGNSWEEVV	DEG_MDM2_SWIB_1	0.591
p.E1421K	DO38147	SKCM	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	0.591
p.P1431L	DO222875	MELA	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	0.1111
p.T1432I	DO219879	SKCA	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	0.0833
p.P1427L	DO229456	SKCA	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	0.2222
p.Q1408R	DO229221	THCA	ICGC	FGNSWEEVV	DEG_MDM2_SWIB_1	0.1389
p.A1412T	ACH-000958	Colon/Colorectal Cancer	CCLE	FGNSWEEVV	DEG_MDM2_SWIB_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FGNSWEEVV

Degron related mutations and impact score

Drug responses associated with FCGBP mutations

All proteins holding degron of FGNSWEEVV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6R7	IgGFc-binding protein	DEG_MDM2_SWIB_1	1415:1423	FGNSWEEVV	MDM2	0.8448	More...