DegronMD - Q9Y6U3(SCIN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G219A	DO49976	CESC	ICGC	GRSELIVVE	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.1389
p.S206Y	DO233697	GACA	ICGC	GRSELIVVE	DEG_APCC_DBOX_1	204:212	Mutation altering degron motif	0.6009
p.E202K	DO219060	HNSC	ICGC	GRSELIVVE	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.2778
p.V222A	DO15070	HNSC	ICGC	GRSELIVVE	DEG_APCC_DBOX_1	204:212	Mutation substituting flanking lysine	0.1667
p.L209M	DO20762	KIRP	ICGC	GRSELIVVE	DEG_APCC_DBOX_1	204:212	Mutation altering degron motif	0.711
p.G218V	DO20917	KIRP	ICGC	GRSELIVVE	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.1667
p.L213F	DO228971	LICA	ICGC	GRSELIVVE	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.3056
p.L213F	DO229019	LICA	ICGC	GRSELIVVE	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.3056
p.V210F	DO229041	LICA	ICGC	GRSELIVVE	DEG_APCC_DBOX_1	204:212	Mutation altering degron motif	0.5957
p.G219R	DO50970	LICA	ICGC	GRSELIVVE	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.1389
p.I221L	DO231754	LINC	ICGC	GRSELIVVE	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.0833
p.L217I	DO47469	SKCM	ICGC	GRSELIVVE	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.1944
p.V211M	SIDM00535	Chondrosarcoma	GDSC	GRSELIVVE	DEG_APCC_DBOX_1	204:212	Mutation altering degron motif	0.6097
p.V211M	SIDM00463	T-Lymphoblastic Leukemia	GDSC	GRSELIVVE	DEG_APCC_DBOX_1	204:212	Mutation altering degron motif	0.6097
p.V211M	SIDM00716	Squamous Cell Lung Carcinoma	GDSC	GRSELIVVE	DEG_APCC_DBOX_1	204:212	Mutation altering degron motif	0.6097
p.V211M	SIDM00260	Gastric Carcinoma	GDSC	GRSELIVVE	DEG_APCC_DBOX_1	204:212	Mutation altering degron motif	0.6097
p.V211M	SIDM00562	Breast Carcinoma	GDSC	GRSELIVVE	DEG_APCC_DBOX_1	204:212	Mutation altering degron motif	0.6097
p.V211M	SIDM00599	Osteosarcoma	GDSC	GRSELIVVE	DEG_APCC_DBOX_1	204:212	Mutation altering degron motif	0.6097
p.V211M	SIDM00587	Biliary Tract Carcinoma	GDSC	GRSELIVVE	DEG_APCC_DBOX_1	204:212	Mutation altering degron motif	0.6097
p.V211M	SIDM01257	Hepatocellular Carcinoma	GDSC	GRSELIVVE	DEG_APCC_DBOX_1	204:212	Mutation altering degron motif	0.6097
p.V211M	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	GRSELIVVE	DEG_APCC_DBOX_1	204:212	Mutation altering degron motif	0.6097
p.V211M	SIDM00079	Ovarian Carcinoma	GDSC	GRSELIVVE	DEG_APCC_DBOX_1	204:212	Mutation altering degron motif	0.6097
p.V211M	SIDM00381	Cervical Carcinoma	GDSC	GRSELIVVE	DEG_APCC_DBOX_1	204:212	Mutation altering degron motif	0.6097
p.L203V	TYK-nu	ovary	COSMIC	GRSELIVVE	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.3056
p.R200P	647-V	urinary tract	COSMIC	GRSELIVVE	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.2222

Kaplan plot for SCIN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCIN

UniProt ID: Q9Y6U3

Entrez ID: 85477

Protein name: Scinderin (Adseverin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SCIN in