DegronMD

Uniprot ID: Q9Y6U3

Source protein: Scinderin

Source gene: SCIN

Class: DEG_APCC_DBOX_1

Location: 204:212

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5811

ASA_SCORE: 54.6222

COIL: 0.4267

CONS_SCORE: 0.5447

DSS_SCORE: 0.4318

HELIX: 0.0108

FCONS_SCORE: 1.1214

RIG_SCORE: 0.7714

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L209M	DO20762	KIRP	ICGC	GRSELIVVE	DEG_APCC_DBOX_1	0.711
p.V211M	SIDM00535	Chondrosarcoma	GDSC	GRSELIVVE	DEG_APCC_DBOX_1	0.6097
p.V211M	SIDM00463	T-Lymphoblastic Leukemia	GDSC	GRSELIVVE	DEG_APCC_DBOX_1	0.6097
p.V211M	SIDM00716	Squamous Cell Lung Carcinoma	GDSC	GRSELIVVE	DEG_APCC_DBOX_1	0.6097
p.V211M	SIDM00260	Gastric Carcinoma	GDSC	GRSELIVVE	DEG_APCC_DBOX_1	0.6097
p.V211M	SIDM00562	Breast Carcinoma	GDSC	GRSELIVVE	DEG_APCC_DBOX_1	0.6097
p.V211M	SIDM00599	Osteosarcoma	GDSC	GRSELIVVE	DEG_APCC_DBOX_1	0.6097
p.V211M	SIDM00587	Biliary Tract Carcinoma	GDSC	GRSELIVVE	DEG_APCC_DBOX_1	0.6097
p.V211M	SIDM01257	Hepatocellular Carcinoma	GDSC	GRSELIVVE	DEG_APCC_DBOX_1	0.6097
p.V211M	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	GRSELIVVE	DEG_APCC_DBOX_1	0.6097
p.V211M	SIDM00079	Ovarian Carcinoma	GDSC	GRSELIVVE	DEG_APCC_DBOX_1	0.6097
p.V211M	SIDM00381	Cervical Carcinoma	GDSC	GRSELIVVE	DEG_APCC_DBOX_1	0.6097
p.S206Y	DO233697	GACA	ICGC	GRSELIVVE	DEG_APCC_DBOX_1	0.6009
p.V210F	DO229041	LICA	ICGC	GRSELIVVE	DEG_APCC_DBOX_1	0.5957
p.L213F	DO228971	LICA	ICGC	GRSELIVVE	DEG_APCC_DBOX_1	0.3056
p.L213F	DO229019	LICA	ICGC	GRSELIVVE	DEG_APCC_DBOX_1	0.3056
p.L203V	TYK-nu	ovary	COSMIC	GRSELIVVE	DEG_APCC_DBOX_1	0.3056
p.E202K	DO219060	HNSC	ICGC	GRSELIVVE	DEG_APCC_DBOX_1	0.2778
p.R200P	647-V	urinary_tract	COSMIC	GRSELIVVE	DEG_APCC_DBOX_1	0.2222
p.L217I	DO47469	SKCM	ICGC	GRSELIVVE	DEG_APCC_DBOX_1	0.1944
p.V222A	DO15070	HNSC	ICGC	GRSELIVVE	DEG_APCC_DBOX_1	0.1667
p.G218V	DO20917	KIRP	ICGC	GRSELIVVE	DEG_APCC_DBOX_1	0.1667
p.G219A	DO49976	CESC	ICGC	GRSELIVVE	DEG_APCC_DBOX_1	0.1389
p.G219R	DO50970	LICA	ICGC	GRSELIVVE	DEG_APCC_DBOX_1	0.1389
p.I221L	DO231754	LINC	ICGC	GRSELIVVE	DEG_APCC_DBOX_1	0.0833

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Drug responses associated with SCIN mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of GRSELIVVE

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6U3	Scinderin	DEG_APCC_DBOX_1	204:212	GRSELIVVE	APC,CDC20,FZR1	0.5811	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRSELIVVE

Degron related mutations and impact score

Drug responses associated with SCIN mutations

All proteins holding degron of GRSELIVVE