DegronMD - Q9Y6Y0(IVNS1ABP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H318R	TCGA-BS-A0TE	UCEC	TCGA	PTSTPKLS	DEG_SCF_FBW7_1	327:334	Mutation rewiring degron network	0.0833
p.G319W	TCGA-EE-A17Z	SKCM	TCGA	PTSTPKLS	DEG_SCF_FBW7_1	327:334	Mutation rewiring degron network	0.1111
p.G319W	TCGA-EE-A3AA	SKCM	TCGA	PTSTPKLS	DEG_SCF_FBW7_1	327:334	Mutation rewiring degron network	0.1111
p.K335N	TCGA-VS-A958	CESC	TCGA	PTSTPKLS	DEG_SCF_FBW7_1	327:334	Mutation rewiring degron network	0.3056
p.Q324H	TCGA-VS-A958	CESC	TCGA	PTSTPKLS	DEG_SCF_FBW7_1	327:334	Mutation rewiring degron network	0.25
p.D344H	TCGA-ZF-A9RL	BLCA	TCGA	PTSTPKLS	DEG_SCF_FBW7_1	327:334	Mutation rewiring degron network	0.0556
p.L323V	DO8264	COAD	ICGC	PTSTPKLS	DEG_SCF_FBW7_1	327:334	Mutation rewiring degron network	0.2222
p.A330T	DO230343	COCA	ICGC	PTSTPKLS	DEG_SCF_FBW7_1	327:334	Mutation altering degron motif	0.7139
p.A330T	DO42568	UCEC	ICGC	PTSTPKLS	DEG_SCF_FBW7_1	327:334	Mutation altering degron motif	0.7139
p.V338A	DO41379	UCEC	ICGC	PTSTPKLS	DEG_SCF_FBW7_1	327:334	Mutation blocking phosphorylation signal	0.6667
p.D344V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PTSTPKLS	DEG_SCF_FBW7_1	327:334	Mutation rewiring degron network	0.0556
p.D344V	ACH-001127	Leukemia	CCLE	PTSTPKLS	DEG_SCF_FBW7_1	327:334	Mutation rewiring degron network	0.0556
p.D344V	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PTSTPKLS	DEG_SCF_FBW7_1	327:334	Mutation rewiring degron network	0.0556
p.S329N	SIDM01608	Endometrial Carcinoma	GDSC	PTSTPKLS	DEG_SCF_FBW7_1	327:334	Mutation altering degron motif	0.7069
p.S329N	ACH-000990	Endometrial/Uterine Cancer	CCLE	PTSTPKLS	DEG_SCF_FBW7_1	327:334	Mutation altering degron motif	0.7069

Kaplan plot for IVNS1ABP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IVNS1ABP

UniProt ID: Q9Y6Y0

Entrez ID: 10625

Protein name: Influenza virus NS1A-binding protein (NS1-BP) (NS1-binding protein) (Aryl hydrocarbon receptor-associated protein 3) (Kelch-like protein 39)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IVNS1ABP in