DegronMD

Uniprot ID: Q9Y6Y0

Source protein: Influenza virus NS1A-binding protein

Source gene: IVNS1ABP

Class: DEG_SCF_FBW7_1

Location: 327:334

E3 ligase: FBXW7

DEGRON score: 0.5684

ASA_SCORE: 65.1375

COIL: 0.7696

CONS_SCORE: 0.3766

DSS_SCORE: 0.6069

HELIX: 0.1036

FCONS_SCORE: 1.059

RIG_SCORE: 0.6461

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H318R	TCGA-BS-A0TE	UCEC	TCGA	PTSTPKLS	DEG_SCF_FBW7_1	0.0833
p.G319W	TCGA-EE-A17Z	SKCM	TCGA	PTSTPKLS	DEG_SCF_FBW7_1	0.1111
p.G319W	TCGA-EE-A3AA	SKCM	TCGA	PTSTPKLS	DEG_SCF_FBW7_1	0.1111
p.K335N	TCGA-VS-A958	CESC	TCGA	PTSTPKLS	DEG_SCF_FBW7_1	0.3056
p.Q324H	TCGA-VS-A958	CESC	TCGA	PTSTPKLS	DEG_SCF_FBW7_1	0.25
p.D344H	TCGA-ZF-A9RL	BLCA	TCGA	PTSTPKLS	DEG_SCF_FBW7_1	0.0556
p.L323V	DO8264	COAD	ICGC	PTSTPKLS	DEG_SCF_FBW7_1	0.2222
p.A330T	DO230343	COCA	ICGC	PTSTPKLS	DEG_SCF_FBW7_1	0.7139
p.A330T	DO42568	UCEC	ICGC	PTSTPKLS	DEG_SCF_FBW7_1	0.7139
p.V338A	DO41379	UCEC	ICGC	PTSTPKLS	DEG_SCF_FBW7_1	0.6667
p.D344V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PTSTPKLS	DEG_SCF_FBW7_1	0.0556
p.D344V	ACH-001127	Leukemia	CCLE	PTSTPKLS	DEG_SCF_FBW7_1	0.0556
p.D344V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PTSTPKLS	DEG_SCF_FBW7_1	0.0556
p.S329N	SIDM01608	Endometrial Carcinoma	GDSC	PTSTPKLS	DEG_SCF_FBW7_1	0.7069
p.S329N	ACH-000990	Endometrial/Uterine Cancer	CCLE	PTSTPKLS	DEG_SCF_FBW7_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6Y0	Influenza virus NS1A-binding protein	DEG_SCF_FBW7_1	327:334	PTSTPKLS	FBXW7	0.5684	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons