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mutLBSgeneDB |
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| Gene summary for CGA |
 Gene summary |
| Basic gene Info. | Gene symbol | CGA |
| Gene name | glycoprotein hormones, alpha polypeptide | |
| Synonyms | CG-ALPHA|FSHA|GPHA1|GPHa|HCG|LHA|TSHA | |
| Cytomap | UCSC genome browser: 6q12-q21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000735.3, NM_001252383.1, | |
| Description | FSH-alphaLSH-alphaTSH-alphaanterior pituitary glycoprotein hormones common subunit alphachoriogonadotropin alpha chainchorionic gonadotrophin subunit alphachorionic gonadotropin, alpha polypeptidefollicle-stimulating hormone alpha chainfollicle-st | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 118850 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000135346 | ||
| HPRD : 00342 | ||
| Vega : OTTHUMG00000015161 | ||
| Protein | UniProt: P01215 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CGA | |
| BioGPS: 1081 | ||
| Pathway | NCI Pathway Interaction Database: CGA | |
| KEGG: CGA | ||
| REACTOME: CGA | ||
| Pathway Commons: CGA | ||
| Context | iHOP: CGA | |
| ligand binding site mutation search in PubMed: CGA | ||
| UCL Cancer Institute: CGA | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for CGA |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | T104 | A105V | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for CGA |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | T104 | A105V | -0.36673197 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for CGA from PDB |
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| Differential gene expression and gene-gene network for CGA |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for CGA |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0001621 | Adrenal Gland Diseases | 1 | Therapeutic |
| umls:C0242656 | Disease Progression | 1 | Biomarker |
| umls:C0018991 | Hemiplegia | 1 | Biomarker |
| umls:C0028960 | Oligospermia | 1 | Therapeutic |
| umls:C0029928 | Ovarian Diseases | 1 | Therapeutic |
| umls:C2931367 | Thyroid cancer, follicular | 1 | Biomarker |
| umls:C0042131 | Uterine Diseases | 1 | Therapeutic |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for CGA |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of CGA go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of CGA |
| Multiple alignments for P01215 in multiple species |
| LBS | AA sequence | # species | Species | A47 | FSKLGAPIYQC | 2 | Mus musculus, Canis lupus familiaris | A47 | FSQPGAPILQC | 1 | Homo sapiens | A47 | FSKPDAPIYQC | 1 | Bos taurus | H103 | FKVENHTACHC | 1 | Homo sapiens | H103 | ARVENHTECHC | 1 | Mus musculus | H103 | VRVENHTECHC | 1 | Bos taurus | H103 | AKVENHTECHC | 1 | Canis lupus familiaris | I49 | KLGAPIYQCMG | 2 | Mus musculus, Canis lupus familiaris | I49 | QPGAPILQCMG | 1 | Homo sapiens | I49 | KPDAPIYQCMG | 1 | Bos taurus | L50 | LGAPIYQCMGC | 2 | Mus musculus, Canis lupus familiaris | L50 | PGAPILQCMGC | 1 | Homo sapiens | L50 | PDAPIYQCMGC | 1 | Bos taurus | N102 | GFKVENHTACH | 1 | Homo sapiens | N102 | NARVENHTECH | 1 | Mus musculus | N102 | NVRVENHTECH | 1 | Bos taurus | N102 | NAKVENHTECH | 1 | Canis lupus familiaris | N90 | VAKAFTKATVM | 3 | Mus musculus, Bos taurus, Canis lupus familiaris | N90 | VAKSYNRVTVM | 1 | Homo sapiens | P48 | SKLGAPIYQCM | 2 | Mus musculus, Canis lupus familiaris | P48 | SQPGAPILQCM | 1 | Homo sapiens | P48 | SKPDAPIYQCM | 1 | Bos taurus | T104 | RVENHTECHCS | 2 | Mus musculus, Bos taurus | T104 | KVENHTACHCS | 1 | Homo sapiens | T104 | KVENHTECHCS | 1 | Canis lupus familiaris | V92 | KAFTKATVMGN | 3 | Mus musculus, Bos taurus, Canis lupus familiaris | V92 | KSYNRVTVMGG | 1 | Homo sapiens |
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