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mutLBSgeneDB |
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| Gene summary for CHI3L1 |
 Gene summary |
| Basic gene Info. | Gene symbol | CHI3L1 |
| Gene name | chitinase 3-like 1 (cartilage glycoprotein-39) | |
| Synonyms | ASRT7|CGP-39|GP-39|GP39|HC-gp39|HCGP-3P|YKL-40|YKL40|YYL-40|hCGP-39 | |
| Cytomap | UCSC genome browser: 1q32.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001276.2, | |
| Description | 39 kDa synovial proteincartilage glycoprotein 39chitinase-3-like protein 1 | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 601525 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000133048 | ||
| HPRD : 03314 | ||
| Vega : OTTHUMG00000042122 | ||
| Protein | UniProt: P36222 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CHI3L1 | |
| BioGPS: 1116 | ||
| Pathway | NCI Pathway Interaction Database: CHI3L1 | |
| KEGG: CHI3L1 | ||
| REACTOME: CHI3L1 | ||
| Pathway Commons: CHI3L1 | ||
| Context | iHOP: CHI3L1 | |
| ligand binding site mutation search in PubMed: CHI3L1 | ||
| UCL Cancer Institute: CHI3L1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for CHI3L1 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | D207 | D207Y | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for CHI3L1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | D207 | D207Y | -0.39478302 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for CHI3L1 from PDB |
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| Differential gene expression and gene-gene network for CHI3L1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for CHI3L1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0017636 | Glioblastoma | 16 | AlteredExpression, Biomarker, GeneticVariation |
| umls:C0017638 | Glioma | 12 | AlteredExpression, Biomarker |
| umls:C0036341 | Schizophrenia | 8 | Biomarker, GeneticVariation |
| umls:C0029408 | Osteoarthritis | 4 | Biomarker |
| umls:C0027626 | Neoplasm Invasiveness | 2 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for CHI3L1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of CHI3L1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NAG | ALDEHYDO-N-ACETYL-D-GLUCOSAMINE | 1nwt | A | D207 | NAG | ALDEHYDO-N-ACETYL-D-GLUCOSAMINE | 1nwt | A | D207 | NAG | ALDEHYDO-N-ACETYL-D-GLUCOSAMINE | 1nwt | A | D207 | NAG | ALDEHYDO-N-ACETYL-D-GLUCOSAMINE | 1nwt | B | D207 | NAG | ALDEHYDO-N-ACETYL-D-GLUCOSAMINE | 1nwt | B | D207 | NAG | ALDEHYDO-N-ACETYL-D-GLUCOSAMINE | 1nwt | C | D207 | NAG | ALDEHYDO-N-ACETYL-D-GLUCOSAMINE | 1nwt | C | D207 | NAG | ALDEHYDO-N-ACETYL-D-GLUCOSAMINE | 1nwt | C | D207 | NAG | ALDEHYDO-N-ACETYL-D-GLUCOSAMINE | 1nwt | D | D207 | NAG | ALDEHYDO-N-ACETYL-D-GLUCOSAMINE | 1nwt | D | D207 | NAG | ALDEHYDO-N-ACETYL-D-GLUCOSAMINE | 1nwt | D | D207 | NAG | ALDEHYDO-N-ACETYL-D-GLUCOSAMINE | 1nwu | A | D207 | NAG | ALDEHYDO-N-ACETYL-D-GLUCOSAMINE | 1nwu | A | D207 | NAG | ALDEHYDO-N-ACETYL-D-GLUCOSAMINE | 1nwu | A | D207 | NAG | ALDEHYDO-N-ACETYL-D-GLUCOSAMINE | 1nwu | B | D207 | NAG | ALDEHYDO-N-ACETYL-D-GLUCOSAMINE | 1nwu | B | D207 | NAG | ALDEHYDO-N-ACETYL-D-GLUCOSAMINE | 1nwu | C | D207 | NAG | ALDEHYDO-N-ACETYL-D-GLUCOSAMINE | 1nwu | C | D207 | NAG | ALDEHYDO-N-ACETYL-D-GLUCOSAMINE | 1nwu | C | D207 | NAG | ALDEHYDO-N-ACETYL-D-GLUCOSAMINE | 1nwu | D | D207 | NAG | ALDEHYDO-N-ACETYL-D-GLUCOSAMINE | 1nwu | D | D207 | NAG | ALDEHYDO-N-ACETYL-D-GLUCOSAMINE | 1nwu | D | D207 |
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| Conservation information for LBS of CHI3L1 |
| Multiple alignments for P36222 in multiple species |
| LBS | AA sequence | # species | Species | A138 | DGLDLAWLYPG | 2 | Homo sapiens, Bos taurus | A138 | DGLDLAWLYPR | 1 | Mus musculus | A177 | LLLSAALSAGK | 2 | Homo sapiens, Mus musculus | A177 | LLLSAAVPAGK | 1 | Bos taurus | D207 | SIMTYDFHGAW | 1 | Homo sapiens | D207 | NLMTYDFHGVW | 1 | Mus musculus | D207 | SLLTYDFHGAW | 1 | Bos taurus | E290 | GRFTKEAGTLA | 2 | Homo sapiens, Mus musculus | E290 | GQFTKEKGILA | 1 | Bos taurus | E70 | -IDTWEWNDVT | 2 | Homo sapiens, Bos taurus | E70 | MLSTWEWNDES | 1 | Mus musculus | F208 | IMTYDFHGAWR | 1 | Homo sapiens | F208 | LMTYDFHGVWR | 1 | Mus musculus | F208 | LLTYDFHGAWR | 1 | Bos taurus | F261 | MGIPTFGRSFT | 1 | Homo sapiens | F261 | MGIPTFGKSFT | 1 | Mus musculus | F261 | MGIPTFGRSYT | 1 | Bos taurus | F58 | HIIYSFANISN | 1 | Homo sapiens | F58 | HIIYSFANISS | 1 | Mus musculus | F58 | HVIYSFANISN | 1 | Bos taurus | G181 | AALSAGKVTID | 1 | Homo sapiens | G181 | AALSAGKVAID | 1 | Mus musculus | G181 | AAVPAGKIAID | 1 | Bos taurus | G98 | LLSVGGWNFGS | 2 | Homo sapiens, Bos taurus | G98 | LLSVGGWKFGE | 1 | Mus musculus | I61 | YSFANISNDH- | 1 | Homo sapiens | I61 | YSFANISSDNM | 1 | Mus musculus | I61 | YSFANISNNE- | 1 | Bos taurus | L140 | LDLAWLYPGRR | 1 | Homo sapiens | L140 | LDLAWLYPRLR | 1 | Mus musculus | L140 | LDLAWLYPGWR | 1 | Bos taurus | M204 | DFISIMTYDFH | 1 | Homo sapiens | M204 | DFINLMTYDFH | 1 | Mus musculus | M204 | DFISLLTYDFH | 1 | Bos taurus | N100 | SVGGWNFGSQR | 2 | Homo sapiens, Bos taurus | N100 | SVGGWKFGEKR | 1 | Mus musculus | N60 | IYSFANISNDH | 1 | Homo sapiens | N60 | IYSFANISSDN | 1 | Mus musculus | N60 | IYSFANISNNE | 1 | Bos taurus | R105 | NFGSQRFSKIA | 2 | Homo sapiens, Bos taurus | R105 | KFGEKRFSEIA | 1 | Mus musculus | R263 | IPTFGRSFTLA | 1 | Homo sapiens | R263 | IPTFGKSFTLA | 1 | Mus musculus | R263 | IPTFGRSYTLA | 1 | Bos taurus | S62 | SFANISNDH-I | 1 | Homo sapiens | S62 | SFANISSDNML | 1 | Mus musculus | S62 | SFANISNNE-I | 1 | Bos taurus | W212 | DFHGAWRGTTG | 1 | Homo sapiens | W212 | DFHGVWRQITG | 1 | Mus musculus | W212 | DFHGAWRQTVG | 1 | Bos taurus | W31 | CYYTSWSQYRE | 2 | Homo sapiens, Bos taurus | W31 | CYFTSWSQYRE | 1 | Mus musculus | W352 | AGAMVWALDLD | 3 | Homo sapiens, Mus musculus, Bos taurus | W69 | H-IDTWEWNDV | 1 | Homo sapiens | W69 | NMLSTWEWNDE | 1 | Mus musculus | W69 | E-IDTWEWNDV | 1 | Bos taurus | W71 | IDTWEWNDVTL | 2 | Homo sapiens, Bos taurus | W71 | LSTWEWNDESN | 1 | Mus musculus | W99 | LSVGGWNFGSQ | 2 | Homo sapiens, Bos taurus | W99 | LSVGGWKFGEK | 1 | Mus musculus | Y141 | DLAWLYPGRRD | 1 | Homo sapiens | Y141 | DLAWLYPRLRD | 1 | Mus musculus | Y141 | DLAWLYPGWRD | 1 | Bos taurus | Y206 | ISIMTYDFHGA | 1 | Homo sapiens | Y206 | INLMTYDFHGV | 1 | Mus musculus | Y206 | ISLLTYDFHGA | 1 | Bos taurus | Y27 | YKLVCYYTSWS | 1 | Homo sapiens | Y27 | YKLVCYFTSWS | 1 | Mus musculus | Y27 | YKLICYYTSWS | 1 | Bos taurus | Y34 | TSWSQYREGDG | 2 | Homo sapiens, Bos taurus | Y34 | TSWSQYREGVG | 1 | Mus musculus |
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