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mutLBSgeneDB |
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| Gene summary for CSNK1G3 |
 Gene summary |
| Basic gene Info. | Gene symbol | CSNK1G3 |
| Gene name | casein kinase 1, gamma 3 | |
| Synonyms | CKI-gamma 3|CSNK1G3L | |
| Cytomap | UCSC genome browser: 5q23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001031812.3, NM_001044723.2,NM_001270572.1,NM_001270573.1,NM_001270574.1, NM_004384.4,NM_001044722.1, | |
| Description | casein kinase I isoform gamma-3 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604253 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000151292 | ||
| HPRD : 05034 | ||
| Vega : OTTHUMG00000128923 | ||
| Protein | UniProt: Q9Y6M4 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CSNK1G3 | |
| BioGPS: 1456 | ||
| Pathway | NCI Pathway Interaction Database: CSNK1G3 | |
| KEGG: CSNK1G3 | ||
| REACTOME: CSNK1G3 | ||
| Pathway Commons: CSNK1G3 | ||
| Context | iHOP: CSNK1G3 | |
| ligand binding site mutation search in PubMed: CSNK1G3 | ||
| UCL Cancer Institute: CSNK1G3 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for CSNK1G3 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | E166 | E166D | COAD | 1 | E86 | E86K | COAD | 1 | P100 | G98V | LUAD | 1 | N53 | G52C | LUAD | 1 | T271 | P272Q | SKCM | 1 | D185 | D185Y | STAD | 1 | P18 | S19G | THCA | 1 | N53 | G52D | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for CSNK1G3 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | P100 | G98V | 0.11314872 | E86 | E86K | -1.2856404 | E166 | E166D | -1.1426993 | D185 | D185Y | -0.78128063 | T271 | P272Q | -0.54149376 | P18 | S19G | -0.37192129 | N53 | G52D | -0.35338084 | N53 | G52C | -0.15281246 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for CSNK1G3 from PDB |
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| Differential gene expression and gene-gene network for CSNK1G3 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for CSNK1G3 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for CSNK1G3 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB04751 | Purvalanol A | Small molecule |  |
| Experimental | DB07488 | {(2Z)-4-AMINO-2-[(4-METHOXYPHENYL)IMINO]-2,3-DIHYDRO-1,3-THIAZOL-5-YL}(4-METHOXYPHENYL)METHANONE | Small molecule |  |
| Experimental | DB07489 | {[4-AMINO-2-(3-CHLOROANILINO)-1,3-THIAZOL-5-YL](4-FLUOROPHENYL)METHANONE | Small molecule |  |
| Experimental | DB07664 | 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of CSNK1G3 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | MG | MAGNESIUM(2+) | 2izs | A | D185 | DKI | CDK1/2 INHIBITOR III | 2chl | A | E166 D185 | 0YO | 2-[5-METHOXY-2-(QUINOLIN-3-YL)PYRIMIDIN-4-YL]-1,5,6,7- TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE | 4hgl | A | E86 P100 D185 | BRK | {(2Z)-4-AMINO-2-[(4-METHOXYPHENYL)IMINO]-2,3-DIHYDRO-1,3-THIAZOL-5-YL}(4-METHOXYPHENYL)METHANONE | 2izr | A | N53 | BRQ | {[4-AMINO-2-(3-CHLOROANILINO)-1,3-THIAZOL-5-YL](4-FLUOROPHENYL)METHANONE | 2izs | A | N53 | 15G | 2-{2-[(3,4-DIFLUOROPHENOXY)METHYL]-5-METHOXYPYRIDIN-4- YL}-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE | 4hgs | A | P100 D185 | P01 | PURVALANOL A | 2izu | A | P100 E166 |
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| Conservation information for LBS of CSNK1G3 |
| Multiple alignments for Q9Y6M4 in multiple species |
| LBS | AA sequence | # species | Species | A70 | TNEYVAIKLEP | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | D125 | GPSLEDLFDLC | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | D162 | NLIYRDVKPEN | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | D185 | VIHIIDFGLAK | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | E117 | NAMVLELLGPS | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | E166 | RDVKPENFLIG | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | E86 | PQLHLEYRFYK | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | F54 | IGCGNFGELRL | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | G120 | VLELLGPSLED | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | G50 | VGKKIGCGNFG | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | I184 | QVIHIIDFGLA | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | I49 | RVGKKIGCGNF | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | K164 | IYRDVKPENFL | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | K72 | EYVAIKLEPMK | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | L116 | YNAMVLELLGP | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | L118 | AMVLELLGPSL | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | L119 | MVLELLGPSLE | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | L169 | KPENFLIGRPG | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | L57 | GNFGELRLGKN | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | N167 | DVKPENFLIGR | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | N53 | KIGCGNFGELR | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | P100 | SGDGIPQVYYF | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | P121 | LELLGPSLEDL | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | P18 | DRMARPSGRSG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P18 | --MARPSGRLG | 1 | Bos taurus | P331 | IGKQLPTPVGA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P331 | ----------- | 1 | Bos taurus | P333 | KQLPTPVGAVQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P333 | ----------- | 1 | Bos taurus | T271 | DTKRATPIEVL | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | T332 | GKQLPTPVGAV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T332 | ----------- | 1 | Bos taurus |
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