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mutLBSgeneDB |
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| Gene summary for PRDX5 |
 Gene summary |
| Basic gene Info. | Gene symbol | PRDX5 |
| Gene name | peroxiredoxin 5 | |
| Synonyms | ACR1|AOEB166|B166|HEL-S-55|PLP|PMP20|PRDX6|PRXV|prx-V | |
| Cytomap | UCSC genome browser: 11q13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_012094.4, NM_181651.2,NM_181652.2, | |
| Description | Alu co-repressor 1TPx type VIantioxidant enzyme B166epididymis secretory protein Li 55liver tissue 2D-page spot 71Bperoxiredoxin Vperoxiredoxin-5, mitochondrialperoxisomal antioxidant enzymethioredoxin peroxidase PMP20thioredoxin reductase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 606583 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000126432 | ||
| HPRD : 05958 | ||
| Vega : OTTHUMG00000168805 | ||
| Protein | UniProt: P30044 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PRDX5 | |
| BioGPS: 25824 | ||
| Pathway | NCI Pathway Interaction Database: PRDX5 | |
| KEGG: PRDX5 | ||
| REACTOME: PRDX5 | ||
| Pathway Commons: PRDX5 | ||
| Context | iHOP: PRDX5 | |
| ligand binding site mutation search in PubMed: PRDX5 | ||
| UCL Cancer Institute: PRDX5 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006979 | response to oxidative stress | 10514471 | GO:0016480 | negative regulation of transcription from RNA polymerase III promoter | 10095767 | GO:0032967 | positive regulation of collagen biosynthetic process | 15276323 | GO:0042744 | hydrogen peroxide catabolic process | 10514471 | GO:0051354 | negative regulation of oxidoreductase activity | 15280035 | GO:0060785 | regulation of apoptosis involved in tissue homeostasis | 15276323 | GO:0070995 | NADPH oxidation | 10751410 | GO:2001057 | reactive nitrogen species metabolic process | 15280035 |
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| Ligand binding site mutations for PRDX5 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | P93 | G94V | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PRDX5 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | P93 | G94V | -0.094457047 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PRDX5 from PDB |
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| Differential gene expression and gene-gene network for PRDX5 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PRDX5 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0002171 | Alopecia Areata | 1 | Biomarker, GeneticVariation |
| umls:C0038356 | Stomach Neoplasms | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PRDX5 |
| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved | DB00995 | Auranofin | Small molecule |  |
| Experimental | DB03608 | Diminazene | Small molecule |  |
| Approved | DB03793 | Benzoic Acid | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PRDX5 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of PRDX5 |
| Multiple alignments for P30044 in multiple species |
| LBS | AA sequence | # species | Species | C100 | AFTPGCSKTHL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C100 | AFTPTCSMSHV | 2 | Arabidopsis thaliana, Arabidopsis thaliana | C100 | AFTPPCS-SQV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C100 | AFTPTCSNQHV | 1 | Oryza sativa subsp. japonica | C100 | AFTPTCSMKHV | 1 | Arabidopsis thaliana | F132 | SVNDPFVMKAW | 4 | Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana | F132 | SVNDAFVTGEW | 1 | Homo sapiens | F132 | AVNDVFVTKAW | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F132 | TVNDVFVTEEW | 1 | Bos taurus | F132 | SVNDVFVIEEW | 1 | Mus musculus | F132 | SVNDAFVTAEW | 1 | Rattus norvegicus | F173 | SLVSLFGNRRL | 2 | Mus musculus, Rattus norvegicus | F173 | KDKGL--GIRS | 2 | Arabidopsis thaliana, Arabidopsis thaliana | F173 | SLVSIFGNRRL | 1 | Homo sapiens | F173 | S--GLLGPLRS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F173 | SLLFLFGNHRL | 1 | Bos taurus | F173 | SEKGL--GIRS | 1 | Oryza sativa subsp. japonica | F173 | KDKGL--GVRS | 1 | Arabidopsis thaliana | G99 | GAFTPGCSKTH | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G99 | GAFTPTCSMSH | 2 | Arabidopsis thaliana, Arabidopsis thaliana | G99 | GAFTPPCS-SQ | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G99 | GAFTPTCSNQH | 1 | Oryza sativa subsp. japonica | G99 | GAFTPTCSMKH | 1 | Arabidopsis thaliana | I172 | DSLVSLFGNRR | 2 | Mus musculus, Rattus norvegicus | I172 | LKDKGL--GIR | 2 | Arabidopsis thaliana, Arabidopsis thaliana | I172 | DSLVSIFGNRR | 1 | Homo sapiens | I172 | AS--GLLGPLR | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I172 | DSLLFLFGNHR | 1 | Bos taurus | I172 | LSEKGL--GIR | 1 | Oryza sativa subsp. japonica | I172 | LKDKGL--GVR | 1 | Arabidopsis thaliana | L169 | ELDLKDKGL-- | 3 | Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana | L169 | LLDDSLVSLFG | 2 | Mus musculus, Rattus norvegicus | L169 | LLDDSLVSIFG | 1 | Homo sapiens | L169 | GFDAS--GLLG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L169 | LLDDSLLFLFG | 1 | Bos taurus | L169 | ELDLSEKGL-- | 1 | Oryza sativa subsp. japonica | P72 | VFEGEPG-KKV | 2 | Mus musculus, Rattus norvegicus | P72 | FFDENDQLQTV | 2 | Arabidopsis thaliana, Arabidopsis thaliana | P72 | VFEGEPG-NKV | 1 | Homo sapiens | P72 | LWENKPE---- | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | P72 | VFEKEPG-NKV | 1 | Bos taurus | P72 | WFDGEDKLQQV | 1 | Oryza sativa subsp. japonica | P72 | FFDENDQLQTA | 1 | Arabidopsis thaliana | P93 | VLFGVPGAFTP | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Oryza sativa subsp. japonica | P93 | ILFGVPGAFTP | 3 | Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana | P93 | IIVGVPGAFTP | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | P93 | VLFGLPGAFTP | 1 | Bos taurus | P98 | PGAFTPGCSKT | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | P98 | PGAFTPTCSMS | 2 | Arabidopsis thaliana, Arabidopsis thaliana | P98 | PGAFTPPCS-S | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | P98 | PGAFTPTCSNQ | 1 | Oryza sativa subsp. japonica | P98 | PGAFTPTCSMK | 1 | Arabidopsis thaliana | R180 | NRRLKRFSMVI | 2 | Mus musculus, Rattus norvegicus | R180 | GIRSRRFALLL | 2 | Arabidopsis thaliana, Arabidopsis thaliana | R180 | NRRLKRFSMVV | 1 | Homo sapiens | R180 | PLRSKRYAAVV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R180 | NHRLKRFSMVI | 1 | Bos taurus | R180 | GIRSRRFALLA | 1 | Oryza sativa subsp. japonica | R180 | GVRSRRFALLL | 1 | Arabidopsis thaliana | T200 | VEPDGTGLTCS | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | T200 | VE-SGGEFTVS | 2 | Arabidopsis thaliana, Arabidopsis thaliana | T200 | IENEVTDVDIS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | T200 | IE-EGGQFTIS | 1 | Oryza sativa subsp. japonica | T200 | VE-NGGEFTVS | 1 | Arabidopsis thaliana | T97 | VPGAFTPGCSK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T97 | VPGAFTPTCSM | 3 | Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana | T97 | VPGAFTPPCS- | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | T97 | LPGAFTPGCSK | 1 | Bos taurus | T97 | VPGAFTPTCSN | 1 | Oryza sativa subsp. japonica |
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