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mutLBSgeneDB |
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| Gene summary for BAZ2B |
 Gene summary |
| Basic gene Info. | Gene symbol | BAZ2B |
| Gene name | bromodomain adjacent to zinc finger domain, 2B | |
| Synonyms | WALp4 | |
| Cytomap | UCSC genome browser: 2q24.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001289975.1, NM_013450.3,NR_110586.1, | |
| Description | bromodomain adjacent to zinc finger domain protein 2B | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605683 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000123636 | ||
| Ensembl : ENSG00000226266 | ||
| HPRD : 09295 | ||
| Vega : OTTHUMG00000132027 | ||
| Protein | UniProt: Q9UIF8 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_BAZ2B | |
| BioGPS: 29994 | ||
| Pathway | NCI Pathway Interaction Database: BAZ2B | |
| KEGG: BAZ2B | ||
| REACTOME: BAZ2B | ||
| Pathway Commons: BAZ2B | ||
| Context | iHOP: BAZ2B | |
| ligand binding site mutation search in PubMed: BAZ2B | ||
| UCL Cancer Institute: BAZ2B | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for BAZ2B |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | D2142,S2144 | D2143N | BRCA | 1 | C1949 | L1948I | COAD | 1 | C1937 | R1938Q | LUAD | 1 | C1949 | L1948F | LUAD | 1 | E2123 | F2125S | STAD | 1 | H2151 | A2149V | UCEC | 1 | F2139 | F2139C | UCEC | 1 | C1960 | H1961R | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for BAZ2B |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | H2151 | A2149V | 0.37888274 | C1937 | R1938Q | -1.9145547 | C1949 | L1948F | -1.2228617 | C1949 | L1948I | -1.0852826 | F2139 | F2139C | -1.0544498 | S2144 | D2143N | -0.79902346 | D2142 | D2143N | -0.79902346 | E2123 | F2125S | -0.77591624 | C1960 | H1961R | -0.29573449 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for BAZ2B from PDB |
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| Differential gene expression and gene-gene network for BAZ2B |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for BAZ2B |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for BAZ2B |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of BAZ2B go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 4qf3 | A | C1937 C1960 | ZN | ZINC(2+) | 4qf3 | B | C1937 C1960 | ZN | ZINC(2+) | 4qf3 | A | C1949 | ZN | ZINC(2+) | 4qf3 | B | C1949 | III | Peptide ligand (GLY,LYS,GLY,LEU,GLY,LYS,GLY) | 4qc3 | A | F2139 | III | Peptide ligand (GLY,GLY,LYS,ALA,PRO,ARG,LYS,GLN) | 4qc1 | A | F2139 D2142 S2144 | III | Peptide ligand (THR,GLY,GLY,LYS,ALA,PRO,ARG,LYS,GLN) | 4qc1 | B | F2139 D2142 S2144 | ZN | ZINC(2+) | 4qc1 | A | H2151 | ZN | ZINC(2+) | 4qc1 | B | H2151 |
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| Conservation information for LBS of BAZ2B |
| Multiple alignments for Q9UIF8 in multiple species |
| LBS | AA sequence | # species | Species |
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