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mutLBSgeneDB |
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| Gene summary for CLEC4D |
 Gene summary |
| Basic gene Info. | Gene symbol | CLEC4D |
| Gene name | C-type lectin domain family 4, member D | |
| Synonyms | CLEC-6|CLEC6|CLECSF8|MCL|MPCL | |
| Cytomap | UCSC genome browser: 12p13.31 | |
| Type of gene | protein-coding | |
| RefGenes | NM_080387.4, | |
| Description | C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 8C-type lectin domain family 4 member DC-type lectin receptorC-type lectin superfamily member 8C-type lectin-like receptor 6macrophage C-type lectin | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 609964 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000166527 | ||
| HPRD : 13074 | ||
| Vega : OTTHUMG00000168674 | ||
| Protein | UniProt: Q8WXI8 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CLEC4D | |
| BioGPS: 338339 | ||
| Pathway | NCI Pathway Interaction Database: CLEC4D | |
| KEGG: CLEC4D | ||
| REACTOME: CLEC4D | ||
| Pathway Commons: CLEC4D | ||
| Context | iHOP: CLEC4D | |
| ligand binding site mutation search in PubMed: CLEC4D | ||
| UCL Cancer Institute: CLEC4D | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for CLEC4D |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | E173 | E173K | SKCM | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for CLEC4D |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | E173 | E173K | -1.1653726 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for CLEC4D from PDB |
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| Differential gene expression and gene-gene network for CLEC4D |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for CLEC4D |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0024115 | Lung Diseases | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for CLEC4D |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of CLEC4D go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | CA | CALCIUM(2+) | 3whd | A | E173 | CA | CALCIUM(2+) | 3whd | C | E173 |
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| Conservation information for LBS of CLEC4D |
| Multiple alignments for Q8WXI8 in multiple species |
| LBS | AA sequence | # species | Species | D175 | HKNEPDNSQGE | 1 | Homo sapiens | D175 | EKGESNDFMEE | 1 | Mus musculus | D175 | KVGEPKDSMEE | 1 | Rattus norvegicus | D196 | KWVWNDFPCHF | 2 | Mus musculus, Rattus norvegicus | D196 | KWAWNDVPCNF | 1 | Homo sapiens | E173 | FWHKNEPDNSQ | 1 | Homo sapiens | E173 | FWEKGESNDFM | 1 | Mus musculus | E173 | FWKVGEPKDSM | 1 | Rattus norvegicus | N176 | KNEPDNSQGEN | 1 | Homo sapiens | N176 | KGESNDFMEED | 1 | Mus musculus | N176 | VGEPKDSMEED | 1 | Rattus norvegicus | N195 | DKWAWNDVPCN | 1 | Homo sapiens | N195 | EKWVWNDFPCH | 1 | Mus musculus | N195 | DKWVWNDFPCH | 1 | Rattus norvegicus |
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