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mutLBSgeneDB |
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| Gene summary for PRKCH |
 Gene summary |
| Basic gene Info. | Gene symbol | PRKCH |
| Gene name | protein kinase C, eta | |
| Synonyms | PKC-L|PKCL|PRKCL|nPKC-eta | |
| Cytomap | UCSC genome browser: 14q23.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_006255.4, | |
| Description | protein kinase C eta type | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605437 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000027075 | ||
| HPRD : 05669 | ||
| Vega : OTTHUMG00000152341 | ||
| Protein | UniProt: P24723 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PRKCH | |
| BioGPS: 5583 | ||
| Pathway | NCI Pathway Interaction Database: PRKCH | |
| KEGG: PRKCH | ||
| REACTOME: PRKCH | ||
| Pathway Commons: PRKCH | ||
| Context | iHOP: PRKCH | |
| ligand binding site mutation search in PubMed: PRKCH | ||
| UCL Cancer Institute: PRKCH | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for PRKCH |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | D497 | F498V | STAD | 1 | V436,E434 | F435S | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PRKCH |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | E434 | F435S | -1.6797186 | V436 | F435S | -1.6797186 | D497 | F498V | -0.52568087 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PRKCH from PDB |
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| Differential gene expression and gene-gene network for PRKCH |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PRKCH |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0007785 | Cerebral Infarction | 3 | Biomarker, GeneticVariation |
| umls:C0028754 | Obesity | 1 | Biomarker |
| umls:C0236969 | Substance-Related Disorders | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PRKCH |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PRKCH go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | 07U | 2-METHYL-N~1~-[3-(PYRIDIN-4-YL)-2,6-NAPHTHYRIDIN-1-YL]PROPANE-1,2-DIAMINE | 3txo | A | E434 V436 D497 |
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| Conservation information for LBS of PRKCH |
| Multiple alignments for P24723 in multiple species |
| LBS | AA sequence | # species | Species | A382 | TGELYAVKVLK | 2 | Mus musculus, Rattus norvegicus | A382 | TGDLYAVKVLK | 1 | Homo sapiens | D440 | FVNGGDLMFHI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D483 | RDLKLDNVLLD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D497 | HCKLADFGMCK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E434 | LFFVMEFVNGG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F366 | LGKGSFGKVML | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F644 | EDVSNFDPDFI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K384 | ELYAVKVLKKD | 2 | Mus musculus, Rattus norvegicus | K384 | DLYAVKVLKKD | 1 | Homo sapiens | L486 | KLDNVLLDHEG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V369 | GSFGKVMLARI | 2 | Mus musculus, Rattus norvegicus | V369 | GSFGKVMLARV | 1 | Homo sapiens | V436 | FVMEFVNGGDL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus |
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