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mutLBSgeneDB |
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| Gene summary for SNRPG |
 Gene summary |
| Basic gene Info. | Gene symbol | SNRPG |
| Gene name | small nuclear ribonucleoprotein polypeptide G | |
| Synonyms | SMG|Sm-G | |
| Cytomap | UCSC genome browser: 2p13.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_003096.2, | |
| Description | sm protein Gsmall nuclear ribonucleoprotein GsnRNP-G | |
| Modification date | 20141215 | |
| dbXrefs | MIM : 603542 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000143977 | ||
| HPRD : 04646 | ||
| Vega : OTTHUMG00000129670 | ||
| Protein | UniProt: P62308 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SNRPG | |
| BioGPS: 6637 | ||
| Pathway | NCI Pathway Interaction Database: SNRPG | |
| KEGG: SNRPG | ||
| REACTOME: SNRPG | ||
| Pathway Commons: SNRPG | ||
| Context | iHOP: SNRPG | |
| ligand binding site mutation search in PubMed: SNRPG | ||
| UCL Cancer Institute: SNRPG | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0000387 | spliceosomal snRNP assembly | 18984161 |
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| Ligand binding site mutations for SNRPG |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | R63 | I62V | LUAD | 1 | H5 | H5R | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for SNRPG |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | R63 | I62V | -1.0630185 | H5 | H5R | -0.75230163 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for SNRPG from PDB |
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| Differential gene expression and gene-gene network for SNRPG |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for SNRPG |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for SNRPG |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of SNRPG go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 4pjo | G | R63 | NUC | Nucleic Acids | 4pjo | g | R63 | NUC | Nucleic Acids | 4pjo | U | R63 | NUC | Nucleic Acids | 4pjo | u | R63 |
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| Conservation information for LBS of SNRPG |
| Multiple alignments for P62308 in multiple species |
| LBS | AA sequence | # species | Species | F37 | RGFDPFMNLVI | 2 | Homo sapiens, Bos taurus | F37 | RGFDPFMNMVI | 1 | Caenorhabditis elegans | F37 | RGFDPFMNVVL | 1 | Drosophila melanogaster | G64 | MVVIRGNSIIM | 2 | Homo sapiens, Bos taurus | G64 | MTVIRGNSVVI | 1 | Caenorhabditis elegans | G64 | MVVIRGNSIVM | 1 | Drosophila melanogaster | H5 | 4 | Homo sapiens, Caenorhabditis elegans, Bos taurus, Drosophila melanogaster | K3 | 4 | Homo sapiens, Caenorhabditis elegans, Bos taurus, Drosophila melanogaster | M38 | GFDPFMNLVID | 2 | Homo sapiens, Bos taurus | M38 | GFDPFMNMVID | 1 | Caenorhabditis elegans | M38 | GFDPFMNVVLD | 1 | Drosophila melanogaster | N39 | FDPFMNLVIDE | 2 | Homo sapiens, Bos taurus | N39 | FDPFMNMVIDE | 1 | Caenorhabditis elegans | N39 | FDPFMNVVLDD | 1 | Drosophila melanogaster | N65 | VVIRGNSIIML | 2 | Homo sapiens, Bos taurus | N65 | TVIRGNSVVIM | 1 | Caenorhabditis elegans | N65 | VVIRGNSIVMV | 1 | Drosophila melanogaster | P36 | LRGFDPFMNLV | 2 | Homo sapiens, Bos taurus | P36 | LRGFDPFMNMV | 1 | Caenorhabditis elegans | P36 | LRGFDPFMNVV | 1 | Drosophila melanogaster | R63 | GMVVIRGNSII | 2 | Homo sapiens, Bos taurus | R63 | GMTVIRGNSVV | 1 | Caenorhabditis elegans | R63 | GMVVIRGNSIV | 1 | Drosophila melanogaster |
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