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mutLBSgeneDB |
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| Gene summary for TSG101 |
 Gene summary |
| Basic gene Info. | Gene symbol | TSG101 |
| Gene name | tumor susceptibility 101 | |
| Synonyms | TSG10|VPS23 | |
| Cytomap | UCSC genome browser: 11p15 | |
| Type of gene | protein-coding | |
| RefGenes | NM_006292.3, | |
| Description | ESCRT-I complex subunit TSG101tumor susceptibility gene 10tumor susceptibility gene 101tumor susceptibility gene 101 proteintumor susceptibility protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 601387 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000074319 | ||
| HPRD : 03229 | ||
| Vega : OTTHUMG00000167725 | ||
| Protein | UniProt: Q99816 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TSG101 | |
| BioGPS: 7251 | ||
| Pathway | NCI Pathway Interaction Database: TSG101 | |
| KEGG: TSG101 | ||
| REACTOME: TSG101 | ||
| Pathway Commons: TSG101 | ||
| Context | iHOP: TSG101 | |
| ligand binding site mutation search in PubMed: TSG101 | ||
| UCL Cancer Institute: TSG101 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | 15611048 |
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| Ligand binding site mutations for TSG101 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | K36,D34 | L35V | LUAD | 1 | P71 | P71T | STAD | 1 | S143 | R144H | STAD | 1 | K16 | Y15C | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for TSG101 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | D34 | L35V | -1.4192392 | K36 | L35V | -1.4192392 | P71 | P71T | -1.2291359 | K16 | Y15C | -1.1872349 | S143 | R144H | -1.0796174 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for TSG101 from PDB |
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| Differential gene expression and gene-gene network for TSG101 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for TSG101 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0346153 | Breast Cancer, Familial | 3 | Biomarker, GeneticVariation |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for TSG101 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of TSG101 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (ACE,PRO,GLU,PRO,THR,ALA,PRO,PRO,GLU,GLU,NH2) | 3p9g | A | D34 K36 P71 S143 | III | Peptide ligand (ACE,PRO,GLU,PRO,THR,ALA,PRO,PRO,GLU,GLU,NH2) | 3p9h | A | D34 P71 S143 | III | Peptide ligand (PRO,GLU,PRO,THR,ALA,PRO,PRO,GLU,GLU) | 3obu | A | D34 S143 | III | Peptide ligand (PRO,GLU,ALA,THR,ALA,PRO,PRO,GLU,GLU) | 3obx | A | D34 S143 | III | Peptide ligand (ILE,LEU,PRO,THR,ALA,PRO,PRO,GLU,TYR) | 4eje | A | D34 S143 | III | Peptide ligand (ILE,LEU,PRO,THR,ALA,PRO,PRO,GLU,TYR) | 4eje | B | D34 S143 | SO4 | SULFATE | 2f0r | A | K16 | III | Peptide ligand (PRO,GLU,PRO,THR,ALA,PRO,PRO,GLU,GLU) | 1m4p | A | P71 S143 | III | Peptide ligand (PRO,GLU,PRO,THR,ALA,PRO,PRO,GLU,GLU) | 1m4q | A | P71 S143 | III | Peptide ligand (PRO,THR,PRO,SER,ALA,PRO,VAL,PRO,LEU) | 3obq | A | S143 |
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| Conservation information for LBS of TSG101 |
| Multiple alignments for Q99816 in multiple species |
| LBS | AA sequence | # species | Species | D19 | KYKYRD----L | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D19 | SVPYEESNKWL | 1 | Arabidopsis thaliana | D19 | ALPYAENTKSL | 1 | Arabidopsis thaliana | D34 | IAMYKDLKPVL | 2 | Mus musculus, Rattus norvegicus | D34 | ITLYKDLKPVL | 1 | Homo sapiens | D34 | ISSYPSLEPKT | 1 | Arabidopsis thaliana | D34 | ISSYTSLDPKT | 1 | Arabidopsis thaliana | E138 | VIFGEEPPVFS | 2 | Mus musculus, Rattus norvegicus | E138 | VVFGDEPPVFS | 1 | Homo sapiens | E138 | AAFARDPPLYS | 1 | Arabidopsis thaliana | E138 | AAFSRDPPLYS | 1 | Arabidopsis thaliana | F142 | EEPPVFSRPTV | 2 | Mus musculus, Rattus norvegicus | F142 | DEPPVFSRP-I | 1 | Homo sapiens | F142 | RDPPLYSRR-- | 1 | Arabidopsis thaliana | F142 | RDPPLYSQR-- | 1 | Arabidopsis thaliana | G57 | LVNLTGTIPVR | 2 | Mus musculus, Rattus norvegicus | G57 | LLQADGTIPMP | 2 | Arabidopsis thaliana, Arabidopsis thaliana | G57 | LMNLTGTIPVP | 1 | Homo sapiens | H102 | KTGK-HVDANG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H102 | KRPHAHVTPSG | 1 | Arabidopsis thaliana | H102 | KRPHSNVSPSG | 1 | Arabidopsis thaliana | I70 | GNIYNIPICLW | 2 | Mus musculus, Rattus norvegicus | I70 | GNTYNIPICLW | 1 | Homo sapiens | I70 | GVTYNIPVIIW | 1 | Arabidopsis thaliana | I70 | GVSYNIPVVIW | 1 | Arabidopsis thaliana | K16 | --SKYKYRD-- | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K16 | GPSSVPYEESN | 1 | Arabidopsis thaliana | K16 | GPSALPYAENT | 1 | Arabidopsis thaliana | K36 | MYKDLKPVLDS | 2 | Mus musculus, Rattus norvegicus | K36 | LYKDLKPVLDS | 1 | Homo sapiens | K36 | SYPSLEPKTAS | 1 | Arabidopsis thaliana | K36 | SYTSLDPKTAT | 1 | Arabidopsis thaliana | K90 | PICFVKPTSSM | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K90 | PCVYVNPTADM | 1 | Arabidopsis thaliana | K90 | PCVYVNPTRDM | 1 | Arabidopsis thaliana | M95 | KPTSSMTIKTG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | M95 | NPTADMIIKRP | 1 | Arabidopsis thaliana | M95 | NPTRDMIIKRP | 1 | Arabidopsis thaliana | N69 | RGNIYNIPICL | 2 | Mus musculus, Rattus norvegicus | N69 | RGNTYNIPICL | 1 | Homo sapiens | N69 | HGVTYNIPVII | 1 | Arabidopsis thaliana | N69 | QGVSYNIPVVI | 1 | Arabidopsis thaliana | P139 | IFGEEPPVFSR | 2 | Mus musculus, Rattus norvegicus | P139 | VFGDEPPVFSR | 1 | Homo sapiens | P139 | AFARDPPLYSR | 1 | Arabidopsis thaliana | P139 | AFSRDPPLYSQ | 1 | Arabidopsis thaliana | P71 | NIYNIPICLWL | 2 | Mus musculus, Rattus norvegicus | P71 | NTYNIPICLWL | 1 | Homo sapiens | P71 | VTYNIPVIIWL | 1 | Arabidopsis thaliana | P71 | VSYNIPVVIWL | 1 | Arabidopsis thaliana | R18 | SKYKYRD---- | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R18 | SSVPYEESNKW | 1 | Arabidopsis thaliana | R18 | SALPYAENTKS | 1 | Arabidopsis thaliana | R64 | IPVRYRGNIYN | 2 | Mus musculus, Rattus norvegicus | R64 | IPVPYRGNTYN | 1 | Homo sapiens | R64 | IPMPFHGVTYN | 1 | Arabidopsis thaliana | R64 | IPMPFQGVSYN | 1 | Arabidopsis thaliana | S143 | EPPVFSRPTVS | 2 | Mus musculus, Rattus norvegicus | S143 | EPPVFSRP-IS | 1 | Homo sapiens | S143 | DPPLYSRR--- | 1 | Arabidopsis thaliana | S143 | DPPLYSQR--- | 1 | Arabidopsis thaliana | S49 | FNDGSSRELVN | 2 | Mus musculus, Rattus norvegicus | S49 | FNDGSSRELMN | 1 | Homo sapiens | S49 | HNDGRSVNLLQ | 1 | Arabidopsis thaliana | S49 | HNDGRSVILLQ | 1 | Arabidopsis thaliana | T56 | ELVNLTGTIPV | 2 | Mus musculus, Rattus norvegicus | T56 | ELMNLTGTIPV | 1 | Homo sapiens | T56 | NLLQADGTIPM | 1 | Arabidopsis thaliana | T56 | ILLQADGTIPM | 1 | Arabidopsis thaliana | T58 | VNLTGTIPVRY | 2 | Mus musculus, Rattus norvegicus | T58 | LQADGTIPMPF | 2 | Arabidopsis thaliana, Arabidopsis thaliana | T58 | MNLTGTIPVPY | 1 | Homo sapiens | T92 | CFVKPTSSMTI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T92 | VYVNPTADMII | 1 | Arabidopsis thaliana | T92 | VYVNPTRDMII | 1 | Arabidopsis thaliana | T96 | PTSSMTIKTGK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T96 | PTADMIIKRPH | 1 | Arabidopsis thaliana | T96 | PTRDMIIKRPH | 1 | Arabidopsis thaliana | V141 | GEEPPVFSRPT | 2 | Mus musculus, Rattus norvegicus | V141 | GDEPPVFSRP- | 1 | Homo sapiens | V141 | ARDPPLYSRR- | 1 | Arabidopsis thaliana | V141 | SRDPPLYSQR- | 1 | Arabidopsis thaliana | V61 | TGTIPVRYRGN | 2 | Mus musculus, Rattus norvegicus | V61 | TGTIPVPYRGN | 1 | Homo sapiens | V61 | DGTIPMPFHGV | 1 | Arabidopsis thaliana | V61 | DGTIPMPFQGV | 1 | Arabidopsis thaliana | Y63 | TIPVRYRGNIY | 2 | Mus musculus, Rattus norvegicus | Y63 | TIPVPYRGNTY | 1 | Homo sapiens | Y63 | TIPMPFHGVTY | 1 | Arabidopsis thaliana | Y63 | TIPMPFQGVSY | 1 | Arabidopsis thaliana | Y68 | YRGNIYNIPIC | 2 | Mus musculus, Rattus norvegicus | Y68 | YRGNTYNIPIC | 1 | Homo sapiens | Y68 | FHGVTYNIPVI | 1 | Arabidopsis thaliana | Y68 | FQGVSYNIPVV | 1 | Arabidopsis thaliana |
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