mutLBSgeneDB |
Gene summary for MAPKAPK3 |
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Basic gene Info. | Gene symbol | MAPKAPK3 |
Gene name | mitogen-activated protein kinase-activated protein kinase 3 | |
Synonyms | 3PK|MAPKAP-K3|MAPKAP3|MAPKAPK-3|MK-3 | |
Cytomap | UCSC genome browser: 3p21.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001243925.1, NM_001243926.1,NM_004635.4, | |
Description | MAP kinase-activated protein kinase 3MAPK-activated protein kinase 3MAPKAP kinase 3chromosome 3p kinase | |
Modification date | 20141207 | |
dbXrefs | MIM : 602130 | |
HGNC : HGNC | ||
Ensembl : ENSG00000114738 | ||
HPRD : 03678 | ||
Vega : OTTHUMG00000156850 | ||
Protein | UniProt: Q16644 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MAPKAPK3 | |
BioGPS: 7867 | ||
Pathway | NCI Pathway Interaction Database: MAPKAPK3 | |
KEGG: MAPKAPK3 | ||
REACTOME: MAPKAPK3 | ||
Pathway Commons: MAPKAPK3 | ||
Context | iHOP: MAPKAPK3 | |
ligand binding site mutation search in PubMed: MAPKAPK3 | ||
UCL Cancer Institute: MAPKAPK3 | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
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GO ID | GO Term | PubMed ID | GO:0018105 | peptidyl-serine phosphorylation | 15850461 | GO:0034097 | response to cytokine | 8774846 |
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Ligand binding site mutations for MAPKAPK3 |
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LBS | AAchange of nsSNV | Cancer type | # samples | D187 | D187N | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for MAPKAPK3 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | D187 | D187N | -1.0036639 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for MAPKAPK3 |
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Phenotype information for MAPKAPK3 |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for MAPKAPK3 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
Experimental | DB07728 | 2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE | Small molecule | ![]() |
Experimental | DB08358 | 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE | Small molecule | ![]() |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | P4O | 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE | 3fhr | A | D187 | F10 | 2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE | 3fxw | A | D187 | 05B | 2'-[2-(1,3-BENZODIOXOL-5-YL)PYRIMIDIN-4-YL]-5',6'-DIHYDROSPIRO[PIPERIDINE-4,7'-PYRROLO[3,2-C]PYRIDIN]-4'(1'H)-ONE | 3r1n | A | D187 | I85 | N-{4-[(3S)-4'-OXO-1',4',5',6'-TETRAHYDROSPIRO[PIPERIDINE-3,7'-PYRROLO[3,2-C]PYRIDIN]-2'-YL]PYRIDIN-2-YL}-3-(TRIFLUOROMETHYL)BENZAMIDE | 3she | A | D187 |
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Conservation information for LBS of MAPKAPK3 |
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LBS | AA sequence | # species | Species | A71 | TGQKCALKLLY | 2 | Homo sapiens, Bos taurus | A71 | SGQKCALKLLY | 2 | Mus musculus, Rattus norvegicus | A71 | TQQNYALKVLL | 1 | Drosophila melanogaster | C120 | LIIMECMEGGE | 2 | Homo sapiens, Bos taurus | C120 | LIVMECMEGGE | 2 | Mus musculus, Rattus norvegicus | C120 | LVVMECMEGGE | 1 | Drosophila melanogaster | D187 | VLKLTDFGFAK | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | D187 | TLKLTDFGFAK | 1 | Drosophila melanogaster | E119 | LLIIMECMEGG | 2 | Homo sapiens, Bos taurus | E119 | LLIVMECMEGG | 2 | Mus musculus, Rattus norvegicus | E119 | LLVVMECMEGG | 1 | Drosophila melanogaster | E122 | VMECMEGGELF | 3 | Drosophila melanogaster, Mus musculus, Rattus norvegicus | E122 | IMECMEGGELF | 2 | Homo sapiens, Bos taurus | E170 | RDVKPENLLYT | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | E170 | RDLKPENLLYT | 1 | Drosophila melanogaster | G123 | MECMEGGELFS | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G123 | MECMEGGELFQ | 1 | Drosophila melanogaster | G124 | ECMEGGELFSR | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G124 | ECMEGGELFQR | 1 | Drosophila melanogaster | G51 | SKQVLGLGVNG | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G51 | SNTVLGYGING | 1 | Drosophila melanogaster | G53 | QVLGLGVNGKV | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G53 | TVLGYGINGKV | 1 | Drosophila melanogaster | K177 | LLYTSKEKDAV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K177 | LLYTTTQPNAT | 1 | Drosophila melanogaster | K177 | LLYTSKDKDAV | 1 | Bos taurus | K73 | QKCALKLLYDS | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | K73 | QNYALKVLLDS | 1 | Drosophila melanogaster | L173 | KPENLLYTSKE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L173 | KPENLLYTTTQ | 1 | Drosophila melanogaster | L173 | KPENLLYTSKD | 1 | Bos taurus | L50 | LSKQVLGLGVN | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | L50 | TSNTVLGYGIN | 1 | Drosophila melanogaster | L52 | KQVLGLGVNGK | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | L52 | NTVLGYGINGK | 1 | Drosophila melanogaster | M118 | CLLIIMECMEG | 2 | Homo sapiens, Bos taurus | M118 | CLLIVMECMEG | 2 | Mus musculus, Rattus norvegicus | M118 | CLLVVMECMEG | 1 | Drosophila melanogaster | M121 | IIMECMEGGEL | 2 | Homo sapiens, Bos taurus | M121 | IVMECMEGGEL | 2 | Mus musculus, Rattus norvegicus | M121 | VVMECMEGGEL | 1 | Drosophila melanogaster | N171 | DVKPENLLYTS | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | N171 | DLKPENLLYTT | 1 | Drosophila melanogaster | T186 | AVLKLTDFGFA | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | T186 | ATLKLTDFGFA | 1 | Drosophila melanogaster | V58 | GVNGKVLECFH | 2 | Homo sapiens, Bos taurus | V58 | GVNGKVLECYH | 2 | Mus musculus, Rattus norvegicus | V58 | GINGKVVQCTH | 1 | Drosophila melanogaster |
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