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mutLBSgeneDB |
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| Gene summary for MAPKAPK3 |
 Gene summary |
| Basic gene Info. | Gene symbol | MAPKAPK3 |
| Gene name | mitogen-activated protein kinase-activated protein kinase 3 | |
| Synonyms | 3PK|MAPKAP-K3|MAPKAP3|MAPKAPK-3|MK-3 | |
| Cytomap | UCSC genome browser: 3p21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001243925.1, NM_001243926.1,NM_004635.4, | |
| Description | MAP kinase-activated protein kinase 3MAPK-activated protein kinase 3MAPKAP kinase 3chromosome 3p kinase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602130 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000114738 | ||
| HPRD : 03678 | ||
| Vega : OTTHUMG00000156850 | ||
| Protein | UniProt: Q16644 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MAPKAPK3 | |
| BioGPS: 7867 | ||
| Pathway | NCI Pathway Interaction Database: MAPKAPK3 | |
| KEGG: MAPKAPK3 | ||
| REACTOME: MAPKAPK3 | ||
| Pathway Commons: MAPKAPK3 | ||
| Context | iHOP: MAPKAPK3 | |
| ligand binding site mutation search in PubMed: MAPKAPK3 | ||
| UCL Cancer Institute: MAPKAPK3 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0018105 | peptidyl-serine phosphorylation | 15850461 | GO:0034097 | response to cytokine | 8774846 |
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| Ligand binding site mutations for MAPKAPK3 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | D187 | D187N | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for MAPKAPK3 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | D187 | D187N | -1.0036639 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for MAPKAPK3 from PDB |
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| Differential gene expression and gene-gene network for MAPKAPK3 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for MAPKAPK3 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for MAPKAPK3 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB07728 | 2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE | Small molecule |  |
| Experimental | DB08358 | 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of MAPKAPK3 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | P4O | 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE | 3fhr | A | D187 | F10 | 2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE | 3fxw | A | D187 | 05B | 2'-[2-(1,3-BENZODIOXOL-5-YL)PYRIMIDIN-4-YL]-5',6'-DIHYDROSPIRO[PIPERIDINE-4,7'-PYRROLO[3,2-C]PYRIDIN]-4'(1'H)-ONE | 3r1n | A | D187 | I85 | N-{4-[(3S)-4'-OXO-1',4',5',6'-TETRAHYDROSPIRO[PIPERIDINE-3,7'-PYRROLO[3,2-C]PYRIDIN]-2'-YL]PYRIDIN-2-YL}-3-(TRIFLUOROMETHYL)BENZAMIDE | 3she | A | D187 |
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| Conservation information for LBS of MAPKAPK3 |
| Multiple alignments for Q16644 in multiple species |
| LBS | AA sequence | # species | Species | A71 | TGQKCALKLLY | 2 | Homo sapiens, Bos taurus | A71 | SGQKCALKLLY | 2 | Mus musculus, Rattus norvegicus | A71 | TQQNYALKVLL | 1 | Drosophila melanogaster | C120 | LIIMECMEGGE | 2 | Homo sapiens, Bos taurus | C120 | LIVMECMEGGE | 2 | Mus musculus, Rattus norvegicus | C120 | LVVMECMEGGE | 1 | Drosophila melanogaster | D187 | VLKLTDFGFAK | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | D187 | TLKLTDFGFAK | 1 | Drosophila melanogaster | E119 | LLIIMECMEGG | 2 | Homo sapiens, Bos taurus | E119 | LLIVMECMEGG | 2 | Mus musculus, Rattus norvegicus | E119 | LLVVMECMEGG | 1 | Drosophila melanogaster | E122 | VMECMEGGELF | 3 | Drosophila melanogaster, Mus musculus, Rattus norvegicus | E122 | IMECMEGGELF | 2 | Homo sapiens, Bos taurus | E170 | RDVKPENLLYT | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | E170 | RDLKPENLLYT | 1 | Drosophila melanogaster | G123 | MECMEGGELFS | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G123 | MECMEGGELFQ | 1 | Drosophila melanogaster | G124 | ECMEGGELFSR | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G124 | ECMEGGELFQR | 1 | Drosophila melanogaster | G51 | SKQVLGLGVNG | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G51 | SNTVLGYGING | 1 | Drosophila melanogaster | G53 | QVLGLGVNGKV | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G53 | TVLGYGINGKV | 1 | Drosophila melanogaster | K177 | LLYTSKEKDAV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K177 | LLYTTTQPNAT | 1 | Drosophila melanogaster | K177 | LLYTSKDKDAV | 1 | Bos taurus | K73 | QKCALKLLYDS | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | K73 | QNYALKVLLDS | 1 | Drosophila melanogaster | L173 | KPENLLYTSKE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L173 | KPENLLYTTTQ | 1 | Drosophila melanogaster | L173 | KPENLLYTSKD | 1 | Bos taurus | L50 | LSKQVLGLGVN | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | L50 | TSNTVLGYGIN | 1 | Drosophila melanogaster | L52 | KQVLGLGVNGK | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | L52 | NTVLGYGINGK | 1 | Drosophila melanogaster | M118 | CLLIIMECMEG | 2 | Homo sapiens, Bos taurus | M118 | CLLIVMECMEG | 2 | Mus musculus, Rattus norvegicus | M118 | CLLVVMECMEG | 1 | Drosophila melanogaster | M121 | IIMECMEGGEL | 2 | Homo sapiens, Bos taurus | M121 | IVMECMEGGEL | 2 | Mus musculus, Rattus norvegicus | M121 | VVMECMEGGEL | 1 | Drosophila melanogaster | N171 | DVKPENLLYTS | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | N171 | DLKPENLLYTT | 1 | Drosophila melanogaster | T186 | AVLKLTDFGFA | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | T186 | ATLKLTDFGFA | 1 | Drosophila melanogaster | V58 | GVNGKVLECFH | 2 | Homo sapiens, Bos taurus | V58 | GVNGKVLECYH | 2 | Mus musculus, Rattus norvegicus | V58 | GINGKVVQCTH | 1 | Drosophila melanogaster |
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