mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ASRGL1
Gene summary
Basic gene Info.Gene symbolASRGL1
Gene nameasparaginase like 1
SynonymsALP|ALP1|CRASH
CytomapUCSC genome browser: 11q12.3
Type of geneprotein-coding
RefGenesNM_001083926.1,
NM_025080.3,
DescriptionL-asparaginaseL-asparagine amidohydrolaseasparaginase-like 1 proteinasparaginase-like protein 1beta-aspartyl-peptidaseisoaspartyl dipeptidaseisoaspartyl peptidase/L-asparaginase
Modification date20141207
dbXrefs MIM : 609212
HGNC : HGNC
Ensembl : ENSG00000162174
HPRD : 07006
Vega : OTTHUMG00000167513
ProteinUniProt: Q7L266
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ASRGL1
BioGPS: 80150
PathwayNCI Pathway Interaction Database: ASRGL1
KEGG: ASRGL1
REACTOME: ASRGL1
Pathway Commons: ASRGL1
ContextiHOP: ASRGL1
ligand binding site mutation search in PubMed: ASRGL1
UCL Cancer Institute: ASRGL1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0033345asparagine catabolic process via L-aspartate19839645


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Ligand binding site mutations for ASRGL1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
T219S217LLUAD1
S200S200LLUAD1
G136P135AOV1
V75M77ISKCM1
G198,R196V197ISTAD1
V75M77TTHCA1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for ASRGL1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
T219S217L0.43445877
V75M77T-1.5591207
V75M77I-1.1527512
G136P135A-0.85236849
G198V197I-0.27135732
R196V197I-0.27135732
S200S200L-0.16542356
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ASRGL1 from PDB

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Differential gene expression and gene-gene network for ASRGL1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ASRGL1 and the right PPI network was created from samples without mutations in the LBS of ASRGL1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for ASRGL1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0162820Dermatitis, Allergic Contact1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for ASRGL1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceuticalDB00128L-Aspartic AcidSmall molecule
Approved|nutraceuticalDB00174L-AsparagineSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ASRGL1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
SO4SULFATE4gduAR196
SO4SULFATE4gduBR196
GLYGLYCINE RESIDUE4hloBR196
GLYGLYCINE RESIDUE4osxBR196
SO4SULFATE4pvqAR196
SO4SULFATE4pvqBR196
GLYGLYCINE RESIDUE4o0dAR196
GLYGLYCINE RESIDUE4o0fBR196
GLYGLYCINE RESIDUE4hlpBR196 G198 S200
GLYGLYCINE RESIDUE4osyBR196 G198 S200
GLYGLYCINE RESIDUE4o0dBR196 G198 S200
MLIMALONATE(2-)4gdtAR196 S200
GLYGLYCINE RESIDUE4hloAR196 S200
GLYGLYCINE RESIDUE4hlpAR196 S200
GLYGLYCINE RESIDUE4osxAR196 S200
GLYGLYCINE RESIDUE4osyAR196 S200
MLIMALONATE(2-)4pvpAR196 S200
GLYGLYCINE RESIDUE4o0fAR196 S200
IASL-ASPARTIC ACID RESIDUE4o0hAR196 S200
ASPL-ASPARTIC ACID4gdvAR196 T219
ASPL-ASPARTIC ACID4gdvBR196 T219
ASPL-ASPARTIC ACID4gdwAR196 T219
ASPL-ASPARTIC ACID4gdwBR196 T219
ASPL-ASPARTIC ACID4pvrAR196 T219
ASPL-ASPARTIC ACID4pvrBR196 T219
ASPL-ASPARTIC ACID4pvsAR196 T219
ASPL-ASPARTIC ACID4pvsBR196 T219
IASL-ASPARTIC ACID RESIDUE4o0hBR196 T219
GLYGLYCINE RESIDUE4hloAT219
GLYGLYCINE RESIDUE4osxAT219
SO4SULFATE4gduAV75 G136
SO4SULFATE4gduBV75 G136
SO4SULFATE4pvqAV75 G136
SO4SULFATE4pvqBV75 G136


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Conservation information for LBS of ASRGL1
Multiple alignments for Q7L266 in multiple species
LBSAA sequence# speciesSpecies
A12VHGGGAS---N3Mus musculus, Rattus norvegicus, Bos taurus
A12VHGGGAG---P1Homo sapiens
A12VH-GGAGIDPN1Arabidopsis thaliana
A12VH-GGAG---H1Danio rerio
A128AQFAAAMGVPE1Homo sapiens
A128EDFARKQGVEI1Arabidopsis thaliana
A128SKFARSMGVPE1Danio rerio
A128EKFAEDMGIPQ1Mus musculus
A128EKFAADMGIPQ1Rattus norvegicus
A128ARFAAANGIPT1Bos taurus
A89GKDLSAGAVSA4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
A89GTKRRCGAVSG1Arabidopsis thaliana
A89GRTLDSGAVSA1Danio rerio
C115EKTPHCFLTDQ1Homo sapiens
C115DKSPHSYLAFS1Arabidopsis thaliana
C115EKTKHLCLTAE1Danio rerio
C115EKTPHCFLTGH1Mus musculus
C115EKTPHCFLTGR1Rattus norvegicus
C115DKTPHCFLTDQ1Bos taurus
C176AVALDCKGNVA1Homo sapiens
C176CVVVDGKGHCA1Arabidopsis thaliana
C176AVAVDMDGNIA1Danio rerio
C176AVALDCRGNLA1Mus musculus
C176AVALDCKGNLA1Rattus norvegicus
C176AVALDCQGNLA1Bos taurus
D199VGRVGDSPCIG2Mus musculus, Rattus norvegicus
D199VGRVGDSPCLG1Homo sapiens
D199MGRIGDSPLIG1Arabidopsis thaliana
D199EGRVGDTPCVG1Danio rerio
D199PGRVGDTPCVG1Bos taurus
D212GYADNDIGAVS2Homo sapiens, Bos taurus
D212GYADNNLGAVS2Mus musculus, Rattus norvegicus
D212TYASEFCG-VS1Arabidopsis thaliana
D212GYADNKIGAVS1Danio rerio
E137PEIPGEKLVTE1Homo sapiens
E137EIVDNEYFVTD1Arabidopsis thaliana
E137PEVPEESLITD1Danio rerio
E137PQVPVEKLITE1Mus musculus
E137PQTPAEKLITE1Rattus norvegicus
E137PTIPGQQLVTE1Bos taurus
E239ALFHVE-QGKT2Mus musculus, Rattus norvegicus
E239TLFHIE-QGKT1Homo sapiens
E239VSAVMEYKGLN1Arabidopsis thaliana
E239VLFHME-QGKT1Danio rerio
E239ALFHVE-QGKS1Bos taurus
E74LNTNGEVEMDA1Homo sapiens
E74LTEKGTVEMEA1Arabidopsis thaliana
E74LNIKGEVEMDA1Danio rerio
E74LNVNGDIEMDA1Mus musculus
E74LNADGDIEMDA1Rattus norvegicus
E74LNENGEVEMDA1Bos taurus
F125QGAAQFAAAMG1Homo sapiens
F125SGAEDFARKQG1Arabidopsis thaliana
F125EGASKFARSMG1Danio rerio
F125HGAEKFAEDMG1Mus musculus
F125RGAEKFAADMG1Rattus norvegicus
F125QGAARFAAANG1Bos taurus
G10VVVHGGGAS--3Mus musculus, Rattus norvegicus, Bos taurus
G10VVVHGGGAG--1Homo sapiens
G10IAVH-GGAGID1Arabidopsis thaliana
G10VVVH-GGAG--1Danio rerio
G13HGGGAS---NI3Mus musculus, Rattus norvegicus, Bos taurus
G13HGGGAG---PI1Homo sapiens
G13H-GGAGIDPNL1Arabidopsis thaliana
G13H-GGAG---HI1Danio rerio
G136VPEIPGEKLVT1Homo sapiens
G136VEIVDNEYFVT1Arabidopsis thaliana
G136VPEVPEESLIT1Danio rerio
G136IPQVPVEKLIT1Mus musculus
G136IPQTPAEKLIT1Rattus norvegicus
G136IPTIPGQQLVT1Bos taurus
G167Q-KNLG-----2Homo sapiens, Bos taurus
G167P-KNSG-----2Mus musculus, Rattus norvegicus
G167PIQMNGLPISI1Arabidopsis thaliana
G167QMGKMG-----1Danio rerio
G178ALDCKGNVAYA1Homo sapiens
G178VVDGKGHCAAG1Arabidopsis thaliana
G178AVDMDGNIACA1Danio rerio
G178ALDCRGNLAYA1Mus musculus
G178ALDCKGNLAYA1Rattus norvegicus
G178ALDCQGNLAYA1Bos taurus
G188ATSTGGIVNKM4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G188GTSTGGLMNKM1Arabidopsis thaliana
G188ATSTGGMINKM1Danio rerio
G198MVGRVGDSPCI2Mus musculus, Rattus norvegicus
G198MVGRVGDSPCL1Homo sapiens
G198MMGRIGDSPLI1Arabidopsis thaliana
G198MEGRVGDTPCV1Danio rerio
G198MPGRVGDTPCV1Bos taurus
G220AVSTTGHGESI4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G220-VSCTGEGEAI1Arabidopsis thaliana
G220AVSPTGHGEAI1Danio rerio
G222STTGHGESILK4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G222SCTGEGEAIIR1Arabidopsis thaliana
G222SPTGHGEAIMK1Danio rerio
G36ATVGYGILREG1Homo sapiens
G36LNLGIIALRSN1Arabidopsis thaliana
G36ARTGYAILQRG1Danio rerio
G36ATEGYKILKAG1Mus musculus
G36ATEGYNILKAG1Rattus norvegicus
G36ATVGYNILKQG1Bos taurus
H114MEKTPHCFLTG2Mus musculus, Rattus norvegicus
H114MEKTPHCFLTD1Homo sapiens
H114MDKSPHSYLAF1Arabidopsis thaliana
H114MEKTKHLCLTA1Danio rerio
H114MDKTPHCFLTD1Bos taurus
H221VSTTGHGESIL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
H221VSCTGEGEAII1Arabidopsis thaliana
H221VSPTGHGEAIM1Danio rerio
I189TSTGGIVNKMV3Homo sapiens, Mus musculus, Rattus norvegicus
I189TSTGGLMNKMM1Arabidopsis thaliana
I189TSTGGMINKME1Danio rerio
I189TSTGGIVNKMP1Bos taurus
I213YADNDIGAVST2Homo sapiens, Bos taurus
I213YADNNLGAVST2Mus musculus, Rattus norvegicus
I213YASEFCG-VSC1Arabidopsis thaliana
I213YADNKIGAVSP1Danio rerio
I225GHGESILKVNL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
I225GEGEAIIRATL1Arabidopsis thaliana
I225GHGEAIMKVTL1Danio rerio
I238LALFHVE-QGK3Mus musculus, Rattus norvegicus, Bos taurus
I238LTLFHIE-QGK1Homo sapiens
I238DVSAVMEYKGL1Arabidopsis thaliana
I238LVLFHME-QGK1Danio rerio
K177VALDCKGNVAY1Homo sapiens
K177VVVDGKGHCAA1Arabidopsis thaliana
K177VAVDMDGNIAC1Danio rerio
K177VALDCRGNLAY1Mus musculus
K177VALDCKGNLAY1Rattus norvegicus
K177VALDCQGNLAY1Bos taurus
K270LIVVSKTGDWV1Homo sapiens
K270LIAVSNKGEVV1Arabidopsis thaliana
K270VVVVDHNGTWA1Danio rerio
K270LILVNKTGDWV1Mus musculus
K270LILINKTGDWV1Rattus norvegicus
K270IIMVNKAGEWA1Bos taurus
L139IPGEKLVTERN1Homo sapiens
L139VDNEYFVTDDN1Arabidopsis thaliana
L139VPEESLITDYA1Danio rerio
L139VPVEKLITERT1Mus musculus
L139TPAEKLITERT1Rattus norvegicus
L139IPGQQLVTERS1Bos taurus
L166CQ-KNLG----2Homo sapiens, Bos taurus
L166CP-KNSG----2Mus musculus, Rattus norvegicus
L166SPIQMNGLPIS1Arabidopsis thaliana
L166CQMGKMG----1Danio rerio
L262SKLKGLGGLIL2Mus musculus, Rattus norvegicus
L262SRVKGLGGLIV1Homo sapiens
L262D--EGFAGLIA1Arabidopsis thaliana
L262ERVDGLGGVVV1Danio rerio
L262SKVKGVGGIIM1Bos taurus
L307TTITDLP---1Homo sapiens
L307----------1Arabidopsis thaliana
L307HFTEPVEEHT1Danio rerio
L307TRTRDLP-C-1Mus musculus
L307TKTRNLPTC-1Rattus norvegicus
L307TSIIDLS---1Bos taurus
M1RASIDVSLVVV2Mus musculus, Rattus norvegicus
M1-----MNPIVV1Homo sapiens
M1----MGGWAIA1Arabidopsis thaliana
M1-----MLPVVV1Danio rerio
M1-----MNPVVV1Bos taurus
M109LARLVMEKTPH3Homo sapiens, Mus musculus, Rattus norvegicus
M109LARLVMDKSPH1Arabidopsis thaliana
M109LARLVMEKTKH1Danio rerio
M109LARLVMDKTPH1Bos taurus
N165DCQ-KNLG---2Homo sapiens, Bos taurus
N165DCP-KNSG---2Mus musculus, Rattus norvegicus
N165DSPIQMNGLPI1Arabidopsis thaliana
N165ECQMGKMG---1Danio rerio
P113VMEKTPHCFLT3Homo sapiens, Mus musculus, Rattus norvegicus
P113VMDKSPHSYLA1Arabidopsis thaliana
P113VMEKTKHLCLT1Danio rerio
P113VMDKTPHCFLT1Bos taurus
P3SIDVSLVVVVH2Mus musculus, Rattus norvegicus
P3---MNPIVVVH1Homo sapiens
P3--MGGWAIAVH1Arabidopsis thaliana
P3---MLPVVVVH1Danio rerio
P3---MNPVVVVH1Bos taurus
Q124DQGAAQFAAAM1Homo sapiens
Q124FSGAEDFARKQ1Arabidopsis thaliana
Q124AEGASKFARSM1Danio rerio
Q124GHGAEKFAEDM1Mus musculus
Q124GRGAEKFAADM1Rattus norvegicus
Q124DQGAARFAAAN1Bos taurus
R196NKMVGRVGDSP3Homo sapiens, Mus musculus, Rattus norvegicus
R196NKMMGRIGDSP1Arabidopsis thaliana
R196NKMEGRVGDTP1Danio rerio
R196NKMPGRVGDTP1Bos taurus
R258DYMKSKLKGLG2Mus musculus, Rattus norvegicus
R258GYMKSRVKGLG1Homo sapiens
R258KHRLD--EGFA1Arabidopsis thaliana
R258AYMKERVDGLG1Danio rerio
R258GHMKSKVKGVG1Bos taurus
R39GYGILREGGSA1Homo sapiens
R39GIIALRSNVSA1Arabidopsis thaliana
R39GYAILQRGGSA1Danio rerio
R39GYKILKAGGSA1Mus musculus
R39GYNILKAGGSA1Rattus norvegicus
R39GYNILKQGGSA1Bos taurus
S200GRVGDSPCIGA2Mus musculus, Rattus norvegicus
S200GRVGDSPCLGA1Homo sapiens
S200GRIGDSPLIGA1Arabidopsis thaliana
S200GRVGDTPCVGC1Danio rerio
S200GRVGDTPCVGS1Bos taurus
S257LDYMKSKLKGL2Mus musculus, Rattus norvegicus
S257LGYMKSRVKGL1Homo sapiens
S257IKHRLD--EGF1Arabidopsis thaliana
S257LAYMKERVDGL1Danio rerio
S257LGHMKSKVKGV1Bos taurus
S280VAKWTSASM-P2Mus musculus, Rattus norvegicus
S280VAKWTSTSM-P1Homo sapiens
S280VCGFNSNGMFR1Arabidopsis thaliana
S280AARFSSLQM-S1Danio rerio
S280AVKWTSTSM-P1Bos taurus
S88DGKDLSAGAVS3Homo sapiens, Mus musculus, Rattus norvegicus
S88DGTKRRCGAVS1Arabidopsis thaliana
S88DGRTLDSGAVS1Danio rerio
S88NGKDLSAGAVS1Bos taurus
T112LVMEKTPHCFL3Homo sapiens, Mus musculus, Rattus norvegicus
T112LVMDKSPHSYL1Arabidopsis thaliana
T112LVMEKTKHLCL1Danio rerio
T112LVMDKTPHCFL1Bos taurus
T168-----TVGAVA5Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus, Bos taurus
T168IYAPETVGCVV1Arabidopsis thaliana
T186AYATSTGGIVN4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
T186AAGTSTGGLMN1Arabidopsis thaliana
T186ACATSTGGMIN1Danio rerio
T219GAVSTTGHGES4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
T219G-VSCTGEGEA1Arabidopsis thaliana
T219GAVSPTGHGEA1Danio rerio
T281AKWTSASM-PW2Mus musculus, Rattus norvegicus
T281AKWTSTSM-PW1Homo sapiens
T281CGFNSNGMFRG1Arabidopsis thaliana
T281ARFSSLQM-SW1Danio rerio
T281VKWTSTSM-PW1Bos taurus
T32MVRAATVGYGI1Homo sapiens
T32LTRCLNLGIIA1Arabidopsis thaliana
T32VKEAARTGYAI1Danio rerio
T32IARAATEGYKI1Mus musculus
T32IAKAATEGYNI1Rattus norvegicus
T32ILRAATVGYNI1Bos taurus
V108KLARLVMEKTP3Homo sapiens, Mus musculus, Rattus norvegicus
V108SLARLVMDKSP1Arabidopsis thaliana
V108QLARLVMEKTK1Danio rerio
V108KLARLVMDKTP1Bos taurus
V140PGEKLVTERN-1Homo sapiens
V140DNEYFVTDDNV1Arabidopsis thaliana
V140PEESLITDYA-1Danio rerio
V140PVEKLITERT-1Mus musculus
V140PAEKLITERT-1Rattus norvegicus
V140PGQQLVTERS-1Bos taurus
V75NTNGEVEMDAS1Homo sapiens
V75TEKGTVEMEAS1Arabidopsis thaliana
V75NIKGEVEMDAL1Danio rerio
V75NVNGDIEMDAS1Mus musculus
V75NADGDIEMDAS1Rattus norvegicus
V75NENGEVEMDAS1Bos taurus
Y254DLSLGYMKSRV1Homo sapiens
Y254DYVIKHRLD--1Arabidopsis thaliana
Y254DLALAYMKERV1Danio rerio
Y254QLALDYMKSKL1Mus musculus
Y254TLALDYMKSKL1Rattus norvegicus
Y254NASLGHMKSKV1Bos taurus
Y35AATVGYGILRE1Homo sapiens
Y35CLNLGIIALRS1Arabidopsis thaliana
Y35AARTGYAILQR1Danio rerio
Y35AATEGYKILKA1Mus musculus
Y35AATEGYNILKA1Rattus norvegicus
Y35AATVGYNILKQ1Bos taurus


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