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mutLBSgeneDB |
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| Gene summary for ZFP91 |
 Gene summary |
| Basic gene Info. | Gene symbol | ZFP91 |
| Gene name | ZFP91 zinc finger protein | |
| Synonyms | DMS-8|DSM-8|PZF|ZFP-91|ZNF757 | |
| Cytomap | UCSC genome browser: 11q12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001197051.1, NM_053023.4, | |
| Description | E3 ubiquitin-protein ligase ZFP91drug resistance-associated sequence in melanoma 8penta zinc finger proteinzinc finger protein 757zinc finger protein 91 homologzinc finger protein homologous to Zfp91 in mouse | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000186660 | ||
| HPRD : 11700 | ||
| Vega : OTTHUMG00000137391 | ||
| Protein | UniProt: Q96JP5 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ZFP91 | |
| BioGPS: 80829 | ||
| Pathway | NCI Pathway Interaction Database: ZFP91 | |
| KEGG: ZFP91 | ||
| REACTOME: ZFP91 | ||
| Pathway Commons: ZFP91 | ||
| Context | iHOP: ZFP91 | |
| ligand binding site mutation search in PubMed: ZFP91 | ||
| UCL Cancer Institute: ZFP91 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0007250 | activation of NF-kappaB-inducing kinase activity | 20682767 | GO:0070534 | protein K63-linked ubiquitination | 20682767 |
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| Ligand binding site mutations for ZFP91 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | H394 | T395N | BLCA | 1 | H390 | R391Q | HNSC | 1 | C377 | R379G | LUSC | 1 | C377 | A378D | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for ZFP91 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | C377 | R379G | -1.2272256 | H390 | R391Q | -0.75310605 | C377 | A378D | -0.69868996 | H394 | T395N | -0.37094512 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for ZFP91 from PDB |
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| Differential gene expression and gene-gene network for ZFP91 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for ZFP91 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for ZFP91 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of ZFP91 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of ZFP91 |
| Multiple alignments for Q96JP5 in multiple species |
| LBS | AA sequence | # species | Species |
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