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mutLBSgeneDB |
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| Gene summary for ING5 |
 Gene summary |
| Basic gene Info. | Gene symbol | ING5 |
| Gene name | inhibitor of growth family, member 5 | |
| Synonyms | p28ING5 | |
| Cytomap | UCSC genome browser: 2q37.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_032329.4, | |
| Description | inhibitor of growth protein 5 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 608525 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000168395 | ||
| HPRD : 16348 | ||
| Vega : OTTHUMG00000151501 | ||
| Protein | UniProt: Q8WYH8 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ING5 | |
| BioGPS: 84289 | ||
| Pathway | NCI Pathway Interaction Database: ING5 | |
| KEGG: ING5 | ||
| REACTOME: ING5 | ||
| Pathway Commons: ING5 | ||
| Context | iHOP: ING5 | |
| ligand binding site mutation search in PubMed: ING5 | ||
| UCL Cancer Institute: ING5 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006260 | DNA replication | 16387653 | GO:0006473 | protein acetylation | 12750254 | GO:0008285 | negative regulation of cell proliferation | 12750254 | GO:0043966 | histone H3 acetylation | 16387653 | GO:0045893 | positive regulation of transcription, DNA-templated | 16387653 | GO:0045926 | negative regulation of growth | 12750254 |
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| Ligand binding site mutations for ING5 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | M199 | M199I | BLCA | 1 | G225 | W227R | LUSC | 1 | D203 | D203N | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for ING5 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | G225 | W227R | -0.76260278 | M199 | M199I | -0.65685776 | D203 | D203N | -0.58384907 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for ING5 from PDB |
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| Differential gene expression and gene-gene network for ING5 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for ING5 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for ING5 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of ING5 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (ALA,ARG,THR,LYS,GLN,THR,ALA) | 3c6w | A | M199 D203 G225 | III | Peptide ligand (ALA,ARG,THR,LYS,GLN,THR,ALA,ARG,LYS,SER,THR) | 3c6w | C | M199 D203 G225 |
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| Conservation information for LBS of ING5 |
| Multiple alignments for Q8WYH8 in multiple species |
| LBS | AA sequence | # species | Species |
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